Exploring the Biological Activity of a Humanized Anti-CD99 ScFv and Antibody for Targeting T Cell Malignancies

Exploring the Biological Activity of a Humanized Anti-CD99 ScFv and Antibody for Targeting T Cell Malignancies

CD99, a type I transmembrane protein, emerges as a promising therapeutic target due to its heightened expression in T cell acute lymphoblastic leukemia (T-ALL). This characteristic renders it a potential marker for minimal residual disease detection and an appealing target for antibody-based treatme...

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Bibliographic Details
Main Authors: Nuchjira Takheaw, Thanathat Pamonsupornwichit, Ratthakorn Chaiwut, Kamonporn Kotemul, Kanokporn Sornsuwan, On-anong Juntit, Umpa Yasamut, Passaworn Cheyasawan, Witida Laopajon, Watchara Kasinrerk, Chatchai Tayapiwatana
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Biomolecules
Subjects:
CD99
T cell malignancies
antibody humanization
antibody therapy
apoptosis
Online Access:https://www.mdpi.com/2218-273X/14/11/1422
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