Exploring the anti-atherosclerosis potential of Ilex kudingcha via network pharmacology and docking studies
Atherosclerosis is caused by multiple factors and has a complex pathogenesis. This study employed network pharmacology to identify key active constituents of Ilex kudingcha and their molecular targets related to atherosclerosis. Six active components were discovered, which interacted with 98 shared...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2025-12-01
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| Series: | CyTA - Journal of Food |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/19476337.2025.2476073 |
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| Summary: | Atherosclerosis is caused by multiple factors and has a complex pathogenesis. This study employed network pharmacology to identify key active constituents of Ilex kudingcha and their molecular targets related to atherosclerosis. Six active components were discovered, which interacted with 98 shared target genes. GO enrichment analysis revealed their roles in various biological functions, including transcription factors and cytokine activity, influencing processes such as wound healing and oxidative stress response. KEGG analysis highlighted involvement in pathways such as lipid and atherosclerosis, AGE-RAGE in diabetes and TNF signaling. Molecular docking showed good affinity of quercetin, kaempferol, and beta-sitosterol with key proteins such as AKT1 and VEGFA. These components exhibit anti-atherosclerosis effects through multitarget and multipathway mechanisms, with quercetin and kaempferol being potential key agents. |
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| ISSN: | 1947-6337 1947-6345 |