Dual Biologic Therapy for Psoriasis in a Patient with Atopic Dermatitis
Ling Ma, Xiaoli Chen, Mohammed Ali Ali Aziz, Aijun Chen, Tao Cai, Shuang Chen Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of ChinaCorrespondence: Tao Cai, Department of Dermatology, The First Affiliated Hospital of Chongqing...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2025-04-01
|
| Series: | Psoriasis: Targets and Therapy |
| Subjects: | |
| Online Access: | https://www.dovepress.com/dual-biologic-therapy-for-psoriasis-in-a-patient-with-atopic-dermatiti-peer-reviewed-fulltext-article-PTT |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850170763016929280 |
|---|---|
| author | Ma L Chen X Aziz MAA Chen A Cai T Chen S |
| author_facet | Ma L Chen X Aziz MAA Chen A Cai T Chen S |
| author_sort | Ma L |
| collection | DOAJ |
| description | Ling Ma, Xiaoli Chen, Mohammed Ali Ali Aziz, Aijun Chen, Tao Cai, Shuang Chen Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of ChinaCorrespondence: Tao Cai, Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing, People’s Republic of China, Email 15902305525@163.com Shuang Chen, Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing, People’s Republic of China, Email shuangchen07@hotmail.comAbstract: Psoriasis and atopic dermatitis (AD), once viewed as mutually exclusive diseases, are increasingly recognized to co-occur in complex inflammatory phenotypes. We present a 17-year-old male with multimorbid atopic conditions, including persistent atopic dermatitis, allergic rhinitis, and asthma, who developed new-onset psoriasis in the absence of previous biologic therapy. Initially misdiagnosed as exacerbated AD, he received ineffective treatment for one year. Treatment with secukinumab yielded limited improvement in psoriatic symptoms and eczematous lesions. AD and psoriasis significantly improved after adding dupilumab for 12 weeks; there were no documented side effects and a durable remission lasting 78 weeks. This case report underscores the importance of vigilance in patients with long-standing AD for newly emerging psoriasis and cautions against attributing all new rashes solely to chronic AD history. This case highlights the potential benefit of dual biologic therapy in managing concurrent type 2 inflammatory diseases and psoriasis, suggesting that a comprehensive immune-modulatory approach may be advantageous for patients with these coexisting conditions.Keywords: dupilumab, secukinumab, psoriasis, atopic dermatitis, dual biologic therapy |
| format | Article |
| id | doaj-art-c9df4a28fbd5408eabf4a7cd95066eb8 |
| institution | OA Journals |
| issn | 2230-326X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Psoriasis: Targets and Therapy |
| spelling | doaj-art-c9df4a28fbd5408eabf4a7cd95066eb82025-08-20T02:20:25ZengDove Medical PressPsoriasis: Targets and Therapy2230-326X2025-04-01Volume 15159161102326Dual Biologic Therapy for Psoriasis in a Patient with Atopic DermatitisMa LChen XAziz MAAChen ACai TChen SLing Ma, Xiaoli Chen, Mohammed Ali Ali Aziz, Aijun Chen, Tao Cai, Shuang Chen Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of ChinaCorrespondence: Tao Cai, Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing, People’s Republic of China, Email 15902305525@163.com Shuang Chen, Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing, People’s Republic of China, Email shuangchen07@hotmail.comAbstract: Psoriasis and atopic dermatitis (AD), once viewed as mutually exclusive diseases, are increasingly recognized to co-occur in complex inflammatory phenotypes. We present a 17-year-old male with multimorbid atopic conditions, including persistent atopic dermatitis, allergic rhinitis, and asthma, who developed new-onset psoriasis in the absence of previous biologic therapy. Initially misdiagnosed as exacerbated AD, he received ineffective treatment for one year. Treatment with secukinumab yielded limited improvement in psoriatic symptoms and eczematous lesions. AD and psoriasis significantly improved after adding dupilumab for 12 weeks; there were no documented side effects and a durable remission lasting 78 weeks. This case report underscores the importance of vigilance in patients with long-standing AD for newly emerging psoriasis and cautions against attributing all new rashes solely to chronic AD history. This case highlights the potential benefit of dual biologic therapy in managing concurrent type 2 inflammatory diseases and psoriasis, suggesting that a comprehensive immune-modulatory approach may be advantageous for patients with these coexisting conditions.Keywords: dupilumab, secukinumab, psoriasis, atopic dermatitis, dual biologic therapyhttps://www.dovepress.com/dual-biologic-therapy-for-psoriasis-in-a-patient-with-atopic-dermatiti-peer-reviewed-fulltext-article-PTTdupilumabsecukinumabpsoriasisatopic dermatitisdual biologic therapy |
| spellingShingle | Ma L Chen X Aziz MAA Chen A Cai T Chen S Dual Biologic Therapy for Psoriasis in a Patient with Atopic Dermatitis Psoriasis: Targets and Therapy dupilumab secukinumab psoriasis atopic dermatitis dual biologic therapy |
| title | Dual Biologic Therapy for Psoriasis in a Patient with Atopic Dermatitis |
| title_full | Dual Biologic Therapy for Psoriasis in a Patient with Atopic Dermatitis |
| title_fullStr | Dual Biologic Therapy for Psoriasis in a Patient with Atopic Dermatitis |
| title_full_unstemmed | Dual Biologic Therapy for Psoriasis in a Patient with Atopic Dermatitis |
| title_short | Dual Biologic Therapy for Psoriasis in a Patient with Atopic Dermatitis |
| title_sort | dual biologic therapy for psoriasis in a patient with atopic dermatitis |
| topic | dupilumab secukinumab psoriasis atopic dermatitis dual biologic therapy |
| url | https://www.dovepress.com/dual-biologic-therapy-for-psoriasis-in-a-patient-with-atopic-dermatiti-peer-reviewed-fulltext-article-PTT |
| work_keys_str_mv | AT mal dualbiologictherapyforpsoriasisinapatientwithatopicdermatitis AT chenx dualbiologictherapyforpsoriasisinapatientwithatopicdermatitis AT azizmaa dualbiologictherapyforpsoriasisinapatientwithatopicdermatitis AT chena dualbiologictherapyforpsoriasisinapatientwithatopicdermatitis AT cait dualbiologictherapyforpsoriasisinapatientwithatopicdermatitis AT chens dualbiologictherapyforpsoriasisinapatientwithatopicdermatitis |