Bioisosterism-driven design of orally active, safe, and broad-spectrum biphenyl-DAPY derivatives as highly potent HIV-1 non-nucleoside reverse transcriptase inhibitors

Bioisosterism-driven design of orally active, safe, and broad-spectrum biphenyl-DAPY derivatives as highly potent HIV-1 non-nucleoside reverse transcriptase inhibitors

This study aimed to identify ideal pharmaceutical candidates featuring strong anti-HIV-1 activity and desirable drug-like characteristics. Our endeavor involved the implementation of a bioisosterism strategy, leading to the discovery of an assemblage of halogen-containing biphenyl-diarylpyrimidines...

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Bibliographic Details
Main Authors: Xiao-Mei Chen, Qing-Qing Hao, Christophe Pannecouque, Erik De Clercq, Shuai Wang, Fen-Er Chen
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Acta Pharmaceutica Sinica B
Subjects:
AIDS
HIV-1
NNRTIs
Diarylpyrimidines
Bioisosterism
Anti-resistance potency
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383525004368
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