Retrospective clinical analysis of time to recovery from diabetic ketoacidosis in Ethiopia
Background: Diabetes is a metabolic disorder that affected > or = 500 million people in 2021. Diabetic ketoacidosis is the most serious acute complication. Because of the significant health burden of diabetic ketoacidosis, we performed a retrospective study on the recovery time and predictors amo...
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Elsevier
2025-03-01
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| Series: | Endocrine and Metabolic Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S266639612500010X |
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| author | Angefa Ayele Dube Jara Alo Edin Digafe Hailu Mihiret Kifle Yohannes Fekadu |
| author_facet | Angefa Ayele Dube Jara Alo Edin Digafe Hailu Mihiret Kifle Yohannes Fekadu |
| author_sort | Angefa Ayele |
| collection | DOAJ |
| description | Background: Diabetes is a metabolic disorder that affected > or = 500 million people in 2021. Diabetic ketoacidosis is the most serious acute complication. Because of the significant health burden of diabetic ketoacidosis, we performed a retrospective study on the recovery time and predictors among adult diabetic mellitus patients in selected public hospitals in Southern Oromia in Ethiopia. Methods: A retrospective follow-up study was conducted of 316 randomly selected adult diabetic ketoacidosis patients admitted between January 1, 2020, and July 31, 2023. A structured checklist was utilized. Data were entered into Epi-data version 4.6 and analyzed with STATA version 17, employing Kaplan-Meier survival curves, log-rank tests, and Cox-proportional hazards models to identify predictors. Results from bivariable and multivariable Cox-regression were reported via adjusted hazard ratio with 95 % confidence intervals. Results: This study included 316 participants, with 256 adults (81.01 %) recovering throughout the follow-up period. The overall DKA recovery rate was 23.8 per 1000 person-hours (95 % CI: 22.21–27.07), and the median recovery time was 42 hr. Significant predictors of recovery time included random blood glucose level [AHR (95 % CI): 0.58 (0.38–0.90)], duration of diabetes mellitus [AHR (95 % CI): 0.24 (0.14–0.69)], and severity of DKA [AHR (95 % CI): 0.46 (0.16–0.84)]. Conclusion: The median DKA recovery time was prolonged, increasing the risk of complications. Blood glucose level, diabetes duration, and DKA severity were predictors of recovery time. Therefore, targeting these factors through research and interventions may improve outcomes and reduce DKA recovery duration. |
| format | Article |
| id | doaj-art-c9d657acb1c245e7897e3100cf4cda04 |
| institution | Kabale University |
| issn | 2666-3961 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Endocrine and Metabolic Science |
| spelling | doaj-art-c9d657acb1c245e7897e3100cf4cda042025-02-09T05:01:29ZengElsevierEndocrine and Metabolic Science2666-39612025-03-0117100224Retrospective clinical analysis of time to recovery from diabetic ketoacidosis in EthiopiaAngefa Ayele0Dube Jara1Alo Edin2Digafe Hailu3Mihiret Kifle4Yohannes Fekadu5Department of Epidemiology, School of Public Health, Institute of Health, Bule Hora University, Bule Hora, Ethiopia; Corresponding author.Department of Public Health, College of Health Sciences, Salale University, Fiche, EthiopiaDepartment of Epidemiology, School of Public Health, Institute of Health, Bule Hora University, Bule Hora, EthiopiaDepartment of Epidemiology, School of Public Health, Institute of Health, Bule Hora University, Bule Hora, EthiopiaDepartment of Biology, college of Natural and Computational Science, Bule Hora University, Bule Hora, EthiopiaDepartment of Epidemiology, School of Public Health, Institute of Health, Bule Hora University, Bule Hora, EthiopiaBackground: Diabetes is a metabolic disorder that affected > or = 500 million people in 2021. Diabetic ketoacidosis is the most serious acute complication. Because of the significant health burden of diabetic ketoacidosis, we performed a retrospective study on the recovery time and predictors among adult diabetic mellitus patients in selected public hospitals in Southern Oromia in Ethiopia. Methods: A retrospective follow-up study was conducted of 316 randomly selected adult diabetic ketoacidosis patients admitted between January 1, 2020, and July 31, 2023. A structured checklist was utilized. Data were entered into Epi-data version 4.6 and analyzed with STATA version 17, employing Kaplan-Meier survival curves, log-rank tests, and Cox-proportional hazards models to identify predictors. Results from bivariable and multivariable Cox-regression were reported via adjusted hazard ratio with 95 % confidence intervals. Results: This study included 316 participants, with 256 adults (81.01 %) recovering throughout the follow-up period. The overall DKA recovery rate was 23.8 per 1000 person-hours (95 % CI: 22.21–27.07), and the median recovery time was 42 hr. Significant predictors of recovery time included random blood glucose level [AHR (95 % CI): 0.58 (0.38–0.90)], duration of diabetes mellitus [AHR (95 % CI): 0.24 (0.14–0.69)], and severity of DKA [AHR (95 % CI): 0.46 (0.16–0.84)]. Conclusion: The median DKA recovery time was prolonged, increasing the risk of complications. Blood glucose level, diabetes duration, and DKA severity were predictors of recovery time. Therefore, targeting these factors through research and interventions may improve outcomes and reduce DKA recovery duration.http://www.sciencedirect.com/science/article/pii/S266639612500010XAdult patientsDiabetic ketoacidosisFollow up studyTime to recover |
| spellingShingle | Angefa Ayele Dube Jara Alo Edin Digafe Hailu Mihiret Kifle Yohannes Fekadu Retrospective clinical analysis of time to recovery from diabetic ketoacidosis in Ethiopia Endocrine and Metabolic Science Adult patients Diabetic ketoacidosis Follow up study Time to recover |
| title | Retrospective clinical analysis of time to recovery from diabetic ketoacidosis in Ethiopia |
| title_full | Retrospective clinical analysis of time to recovery from diabetic ketoacidosis in Ethiopia |
| title_fullStr | Retrospective clinical analysis of time to recovery from diabetic ketoacidosis in Ethiopia |
| title_full_unstemmed | Retrospective clinical analysis of time to recovery from diabetic ketoacidosis in Ethiopia |
| title_short | Retrospective clinical analysis of time to recovery from diabetic ketoacidosis in Ethiopia |
| title_sort | retrospective clinical analysis of time to recovery from diabetic ketoacidosis in ethiopia |
| topic | Adult patients Diabetic ketoacidosis Follow up study Time to recover |
| url | http://www.sciencedirect.com/science/article/pii/S266639612500010X |
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