Vitamin D Levels and Lipid Response to Atorvastatin
Adequate vitamin D levels are necessary for good vascular health. 1,25-dihydroxycholecalciferol activates CYP3A4, an enzyme of the cytochrome P450 system, which metabolizes atorvastatin to its main metabolites. The objective of this study was to evaluate the response of cholesterol and triglycerides...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
|
| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2010/320721 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850174222435876864 |
|---|---|
| author | José Luis Pérez-Castrillón Laura Abad Manteca Gemma Vega Javier del Pino Montes Daniel de Luis Antonio Dueňas Laita |
| author_facet | José Luis Pérez-Castrillón Laura Abad Manteca Gemma Vega Javier del Pino Montes Daniel de Luis Antonio Dueňas Laita |
| author_sort | José Luis Pérez-Castrillón |
| collection | DOAJ |
| description | Adequate vitamin D levels are necessary for good vascular health. 1,25-dihydroxycholecalciferol activates CYP3A4, an enzyme of the cytochrome P450 system, which metabolizes atorvastatin to its main metabolites. The objective of this study was to evaluate the response of cholesterol and triglycerides to
atorvastatin according to vitamin D levels. Sixty-three patients with acute myocardial infarction treated with low and high doses of atorvastatin were
included. Levels of total cholesterol, triglycerides, HDL cholesterol, and LDL cholesterol
were measured at baseline and at 12 months of follow-up. Baseline
levels of 25-hydroxyvitamin D (25-OHD) were classified as deficient (<30 nmol/L), insufficient (30–50 nmol/L), and normal (>50 nmol/L). In patients with
25-OHD <30 nmol/L, there were no significant changes in levels of total
cholesterol (173±47 mg/dL versus 164±51 mg/dL), triglycerides (151±49 mg/dL
versus 177±94 mg/dL), and LDL cholesterol (111±48 mg/dL versus 92 45± mg/dL); whereas patients with insufficient (30–50 nmol/L) and normal vitamin D (>50 nmol/L) had a good response to atorvastatin. We suggest that vitamin D
concentrations >30 nmol/L may be required for atorvastatin to reduce lipid
levels in patients with acute myocardial infarction. |
| format | Article |
| id | doaj-art-c9d28865bc0d4883b92480eb7042e8ec |
| institution | OA Journals |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-c9d28865bc0d4883b92480eb7042e8ec2025-08-20T02:19:42ZengWileyInternational Journal of Endocrinology1687-83371687-83452010-01-01201010.1155/2010/320721320721Vitamin D Levels and Lipid Response to AtorvastatinJosé Luis Pérez-Castrillón0Laura Abad Manteca1Gemma Vega2Javier del Pino Montes3Daniel de Luis4Antonio Dueňas Laita5Department Internal Medicine, Rio Hortega Universitary Hospital, C/ Dulzaina 2, University of Valladolid, 47012 Valladolid, SpainDepartment Internal Medicine, Rio Hortega Universitary Hospital, C/ Dulzaina 2, University of Valladolid, 47012 Valladolid, SpainDepartment Internal Medicine, Rio Hortega Universitary Hospital, C/ Dulzaina 2, University of Valladolid, 47012 Valladolid, SpainRETICEF, SpainDepartment Internal Medicine, Rio Hortega Universitary Hospital, C/ Dulzaina 2, University of Valladolid, 47012 Valladolid, SpainDepartment Internal Medicine, Rio Hortega Universitary Hospital, C/ Dulzaina 2, University of Valladolid, 47012 Valladolid, SpainAdequate vitamin D levels are necessary for good vascular health. 1,25-dihydroxycholecalciferol activates CYP3A4, an enzyme of the cytochrome P450 system, which metabolizes atorvastatin to its main metabolites. The objective of this study was to evaluate the response of cholesterol and triglycerides to atorvastatin according to vitamin D levels. Sixty-three patients with acute myocardial infarction treated with low and high doses of atorvastatin were included. Levels of total cholesterol, triglycerides, HDL cholesterol, and LDL cholesterol were measured at baseline and at 12 months of follow-up. Baseline levels of 25-hydroxyvitamin D (25-OHD) were classified as deficient (<30 nmol/L), insufficient (30–50 nmol/L), and normal (>50 nmol/L). In patients with 25-OHD <30 nmol/L, there were no significant changes in levels of total cholesterol (173±47 mg/dL versus 164±51 mg/dL), triglycerides (151±49 mg/dL versus 177±94 mg/dL), and LDL cholesterol (111±48 mg/dL versus 92 45± mg/dL); whereas patients with insufficient (30–50 nmol/L) and normal vitamin D (>50 nmol/L) had a good response to atorvastatin. We suggest that vitamin D concentrations >30 nmol/L may be required for atorvastatin to reduce lipid levels in patients with acute myocardial infarction.http://dx.doi.org/10.1155/2010/320721 |
| spellingShingle | José Luis Pérez-Castrillón Laura Abad Manteca Gemma Vega Javier del Pino Montes Daniel de Luis Antonio Dueňas Laita Vitamin D Levels and Lipid Response to Atorvastatin International Journal of Endocrinology |
| title | Vitamin D Levels and Lipid Response to Atorvastatin |
| title_full | Vitamin D Levels and Lipid Response to Atorvastatin |
| title_fullStr | Vitamin D Levels and Lipid Response to Atorvastatin |
| title_full_unstemmed | Vitamin D Levels and Lipid Response to Atorvastatin |
| title_short | Vitamin D Levels and Lipid Response to Atorvastatin |
| title_sort | vitamin d levels and lipid response to atorvastatin |
| url | http://dx.doi.org/10.1155/2010/320721 |
| work_keys_str_mv | AT joseluisperezcastrillon vitamindlevelsandlipidresponsetoatorvastatin AT lauraabadmanteca vitamindlevelsandlipidresponsetoatorvastatin AT gemmavega vitamindlevelsandlipidresponsetoatorvastatin AT javierdelpinomontes vitamindlevelsandlipidresponsetoatorvastatin AT danieldeluis vitamindlevelsandlipidresponsetoatorvastatin AT antonioduenaslaita vitamindlevelsandlipidresponsetoatorvastatin |