Co-expression of IL-15 and CCL21 strengthens CAR-NK cells to eliminate tumors in concert with T cells and equips them with PI3K/AKT/mTOR signal signature

Co-expression of IL-15 and CCL21 strengthens CAR-NK cells to eliminate tumors in concert with T cells and equips them with PI3K/AKT/mTOR signal signature

Background Chimeric antigen receptor (CAR)-natural killer (NK) cell therapy has demonstrated safety and feasibility in clinical settings; however, limited efficacy due to intrinsic dysfunction and extrinsic suppression remains an unresolved issue. T cells provide multifaceted support to NK cell-medi...

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Main Authors: Jie Zhou, Lu Tang, Yu Hu, Jun Deng, Yingying Li, Wei Xiong, Jianghua Wu, Jia Xu, Wenjing Luo, Heng Mei, Xindi Wang, Zhaozhao Chen, Chenggong Li, Zhongpei Huang, Zhuolin Wu, Yinqiang Zhang, Yun Kang, Qiaolin Liu
Format: Article
Language:English
Published: BMJ Publishing Group 2025-06-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/13/6/e010822.full
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