A multicenter cross-sectional study to elucidate altered resting-state functional connectivity of the insular cortex in anorexia nervosa, segmented by functional localization
Abstract Although changes in insular function have been thought to play a central role in the pathophysiology of anorexia nervosa (AN), due to factors such as insufficient sample size, there have been no studies examining changes in resting-state functional connectivity (rsFC) between insula and who...
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2025-05-01
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| author | Yusuke Sudo Rio Kamashita Tsunehiko Takamura Sayo Hamatani Noriko Numata Koji Matsumoto Yasuhiro Sato Yumi Hamamoto Tomotaka Shoji Tomohiko Muratsubaki Motoaki Sugiura Shin Fukudo Michiko Kawabata Momo Sunada Tomomi Noda Keima Tose Masanori Isobe Naoki Kodama Shingo Kakeda Masatoshi Takahashi Hiroaki Adachi Shu Takakura Motoharu Gondo Kazufumi Yoshihara Yoshiya Moriguchi Eiji Shimizu Atsushi Sekiguchi Yoshiyuki Hirano |
| author_facet | Yusuke Sudo Rio Kamashita Tsunehiko Takamura Sayo Hamatani Noriko Numata Koji Matsumoto Yasuhiro Sato Yumi Hamamoto Tomotaka Shoji Tomohiko Muratsubaki Motoaki Sugiura Shin Fukudo Michiko Kawabata Momo Sunada Tomomi Noda Keima Tose Masanori Isobe Naoki Kodama Shingo Kakeda Masatoshi Takahashi Hiroaki Adachi Shu Takakura Motoharu Gondo Kazufumi Yoshihara Yoshiya Moriguchi Eiji Shimizu Atsushi Sekiguchi Yoshiyuki Hirano |
| author_sort | Yusuke Sudo |
| collection | DOAJ |
| description | Abstract Although changes in insular function have been thought to play a central role in the pathophysiology of anorexia nervosa (AN), due to factors such as insufficient sample size, there have been no studies examining changes in resting-state functional connectivity (rsFC) between insula and whole brain in AN, based on functional localization of insula. Here, we subdivided insula into 6 regions per side based on functional localization and reanalyzed previously published functional magnetic resonance imaging data from 114 female patients with AN and 135 female healthy controls (HC). We calculated the rsFCs between ROIs and compared the results between groups, with the 12 insular regions serving as seed ROIs and 142 regions of the whole brain as target ROIs. Compared to HC, AN patients had a increased rsFC between dorsal anterior insula (daIC) and amygdala, and a decreased rsFC between posterior division of dorsal middle insula (pdmIC) and opercular cortex (false discovery rate [FDR] corrected p-value < 0.05 with analysis-level correction, which means that FDR correction was applied to all seed ROIs and all target ROI combinations). These rsFC changes may be the neurological basis for AN symptoms, such as hypersensitivity to negative stimuli, taste disorder, and enhanced taste aversion learning. |
| format | Article |
| id | doaj-art-c9ce85d0480f4c6ab38d29ef71a4f594 |
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| issn | 2045-2322 |
| language | English |
| publishDate | 2025-05-01 |
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| spelling | doaj-art-c9ce85d0480f4c6ab38d29ef71a4f5942025-08-20T03:16:52ZengNature PortfolioScientific Reports2045-23222025-05-0115111410.1038/s41598-025-03641-0A multicenter cross-sectional study to elucidate altered resting-state functional connectivity of the insular cortex in anorexia nervosa, segmented by functional localizationYusuke Sudo0Rio Kamashita1Tsunehiko Takamura2Sayo Hamatani3Noriko Numata4Koji Matsumoto5Yasuhiro Sato6Yumi Hamamoto7Tomotaka Shoji8Tomohiko Muratsubaki9Motoaki Sugiura10Shin Fukudo11Michiko Kawabata12Momo Sunada13Tomomi Noda14Keima Tose15Masanori Isobe16Naoki Kodama17Shingo Kakeda18Masatoshi Takahashi19Hiroaki Adachi20Shu Takakura21Motoharu Gondo22Kazufumi Yoshihara23Yoshiya Moriguchi24Eiji Shimizu25Atsushi Sekiguchi26Yoshiyuki Hirano27Research Center for Child Mental Development Chiba UniversityResearch Center for Child Mental Development Chiba UniversityDepartment of Behavioral Medicine, National Institute of Mental Health, National Center of Neurology and PsychiatryResearch Center for Child Mental Development Chiba UniversityResearch Center for Child Mental Development Chiba UniversityDepartment of Radiology, Chiba University HospitalDepartment of Psychosomatic Medicine, Tohoku University HospitalResearch Institute of Electrical Communication, Tohoku UniversityDepartment of Psychosomatic Medicine, Tohoku University HospitalDepartment of Psychosomatic Medicine, Tohoku University HospitalDepartment of Human Brain Science, Institute of Development, Aging and Cancer, Tohoku UniversityDepartment of Psychosomatic Medicine, Tohoku University HospitalDepartment of Psychiatry, Kyoto University Graduate School of MedicineDepartment of Psychiatry, Kyoto University Graduate School of MedicineDepartment of Psychiatry, Kyoto University Graduate School of MedicineDepartment of Psychiatry, Kyoto University Graduate School of MedicineDepartment of Psychiatry, Kyoto University Graduate School of MedicineDivision of Psychosomatic Medicine, Department of Neurology, University of Occupational and Environmental HealthDepartment of Radiology, Hirosaki University Graduate School of MedicineDivision of Psychosomatic Medicine, Department of Neurology, University of Occupational and Environmental HealthDepartment of Neurology, University of Occupational and Environmental Health School of MedicineDepartment of Psychosomatic Medicine, Kyushu University HospitalDepartment of Psychosomatic Medicine, Kyushu University HospitalDepartment of Psychosomatic Medicine, Kyushu University HospitalDepartment of Behavioral Medicine, National Institute of Mental Health, National Center of Neurology and PsychiatryResearch Center for Child Mental Development Chiba UniversityDepartment of Behavioral Medicine, National Institute of Mental Health, National Center of Neurology and PsychiatryResearch Center for Child Mental Development Chiba UniversityAbstract Although changes in insular function have been thought to play a central role in the pathophysiology of anorexia nervosa (AN), due to factors such as insufficient sample size, there have been no studies examining changes in resting-state functional connectivity (rsFC) between insula and whole brain in AN, based on functional localization of insula. Here, we subdivided insula into 6 regions per side based on functional localization and reanalyzed previously published functional magnetic resonance imaging data from 114 female patients with AN and 135 female healthy controls (HC). We calculated the rsFCs between ROIs and compared the results between groups, with the 12 insular regions serving as seed ROIs and 142 regions of the whole brain as target ROIs. Compared to HC, AN patients had a increased rsFC between dorsal anterior insula (daIC) and amygdala, and a decreased rsFC between posterior division of dorsal middle insula (pdmIC) and opercular cortex (false discovery rate [FDR] corrected p-value < 0.05 with analysis-level correction, which means that FDR correction was applied to all seed ROIs and all target ROI combinations). These rsFC changes may be the neurological basis for AN symptoms, such as hypersensitivity to negative stimuli, taste disorder, and enhanced taste aversion learning.https://doi.org/10.1038/s41598-025-03641-0Eating disorderAnorexia nervosaResting-state functional connectivityInsulaTaste |
| spellingShingle | Yusuke Sudo Rio Kamashita Tsunehiko Takamura Sayo Hamatani Noriko Numata Koji Matsumoto Yasuhiro Sato Yumi Hamamoto Tomotaka Shoji Tomohiko Muratsubaki Motoaki Sugiura Shin Fukudo Michiko Kawabata Momo Sunada Tomomi Noda Keima Tose Masanori Isobe Naoki Kodama Shingo Kakeda Masatoshi Takahashi Hiroaki Adachi Shu Takakura Motoharu Gondo Kazufumi Yoshihara Yoshiya Moriguchi Eiji Shimizu Atsushi Sekiguchi Yoshiyuki Hirano A multicenter cross-sectional study to elucidate altered resting-state functional connectivity of the insular cortex in anorexia nervosa, segmented by functional localization Scientific Reports Eating disorder Anorexia nervosa Resting-state functional connectivity Insula Taste |
| title | A multicenter cross-sectional study to elucidate altered resting-state functional connectivity of the insular cortex in anorexia nervosa, segmented by functional localization |
| title_full | A multicenter cross-sectional study to elucidate altered resting-state functional connectivity of the insular cortex in anorexia nervosa, segmented by functional localization |
| title_fullStr | A multicenter cross-sectional study to elucidate altered resting-state functional connectivity of the insular cortex in anorexia nervosa, segmented by functional localization |
| title_full_unstemmed | A multicenter cross-sectional study to elucidate altered resting-state functional connectivity of the insular cortex in anorexia nervosa, segmented by functional localization |
| title_short | A multicenter cross-sectional study to elucidate altered resting-state functional connectivity of the insular cortex in anorexia nervosa, segmented by functional localization |
| title_sort | multicenter cross sectional study to elucidate altered resting state functional connectivity of the insular cortex in anorexia nervosa segmented by functional localization |
| topic | Eating disorder Anorexia nervosa Resting-state functional connectivity Insula Taste |
| url | https://doi.org/10.1038/s41598-025-03641-0 |
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