Complete genome of single locus sequence typing D1 strain Cutibacterium acnes CN6 isolated from healthy facial skin
Abstract Objectives Cutibacterium acnes is a Gram-positive bacterium commonly found on human skin, particularly in sebaceous areas. While it is typically considered a commensal, specific strain types based on single locus sequence typing (SLST) have been associated with pathogenic conditions or heal...
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2024-11-01
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| Online Access: | https://doi.org/10.1186/s12863-024-01277-z |
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| author | Ikwhan Kim Da-Ryung Jung Ryeong-Hui Kim Dokyung Lee YeonGyun Jung Ji Hoon Ha Eun Kyung Lee Jin Mo Kim Jin Young Kim Jun-Hwan Jang Jun-Tae Bae Yoon Soo Cho Jae-Ho Shin |
| author_facet | Ikwhan Kim Da-Ryung Jung Ryeong-Hui Kim Dokyung Lee YeonGyun Jung Ji Hoon Ha Eun Kyung Lee Jin Mo Kim Jin Young Kim Jun-Hwan Jang Jun-Tae Bae Yoon Soo Cho Jae-Ho Shin |
| author_sort | Ikwhan Kim |
| collection | DOAJ |
| description | Abstract Objectives Cutibacterium acnes is a Gram-positive bacterium commonly found on human skin, particularly in sebaceous areas. While it is typically considered a commensal, specific strain types based on single locus sequence typing (SLST) have been associated with pathogenic conditions or healthy skin. Recently, SLST D1 strains, part of phylotype IA1, have received attention for their potential benefits related to skin health. However, their genetic characteristics remain underexplored. Therefore, the whole genome of C. acnes CN6, an SLST D1 strain isolated from the facial skin of a healthy individual, was sequenced to expand the understanding of SLST D1 strains and identify genomic features that may support skin health. Data description The whole genome sequencing of C. acnes CN6 was conducted using MinION reads based on de novo assembly, revealing a single circular complete chromosome. With the length of 2,550,458 bp and G + C content of 60.04%, the genome contains 2,492 genes, including 2,433 CDSs, 9 rRNAs, 46 tRNAs, 4 ncRNAs, and 134 pseudo genes. Previously predicted virulence proteins of C. ances were detected in the genome. Genome comparation with 200 C. acnes strains isolated from healthy facial skin revealed SLST D1 strain-specific genes and a unique variant of the znuC gene in D1 strains. |
| format | Article |
| id | doaj-art-c9cc1ac8c72943f89f6c076eca491301 |
| institution | DOAJ |
| issn | 2730-6844 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
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| series | BMC Genomic Data |
| spelling | doaj-art-c9cc1ac8c72943f89f6c076eca4913012025-08-20T02:50:02ZengBMCBMC Genomic Data2730-68442024-11-012511410.1186/s12863-024-01277-zComplete genome of single locus sequence typing D1 strain Cutibacterium acnes CN6 isolated from healthy facial skinIkwhan Kim0Da-Ryung Jung1Ryeong-Hui Kim2Dokyung Lee3YeonGyun Jung4Ji Hoon Ha5Eun Kyung Lee6Jin Mo Kim7Jin Young Kim8Jun-Hwan Jang9Jun-Tae Bae10Yoon Soo Cho11Jae-Ho Shin12Department of Integrative Biology, Kyungpook National UniversityDepartment of Applied Biosciences, Kyungpook National UniversityNGS Core Facility, Kyungpook National UniversityNGS Core Facility, Kyungpook National UniversityBurn Institute, Hangang Sacred Heart Hospital, Hallym University College of MedicineR&D CenterDepartment of Rehabilitation Medicine, Hangang Sacred Heart Hospital, Hallym University College of MedicineR&D CenterR&D CenterJ2KBIOJ2KBIODepartment of Rehabilitation Medicine, Hangang Sacred Heart Hospital, Hallym University College of MedicineDepartment of Integrative Biology, Kyungpook National UniversityAbstract Objectives Cutibacterium acnes is a Gram-positive bacterium commonly found on human skin, particularly in sebaceous areas. While it is typically considered a commensal, specific strain types based on single locus sequence typing (SLST) have been associated with pathogenic conditions or healthy skin. Recently, SLST D1 strains, part of phylotype IA1, have received attention for their potential benefits related to skin health. However, their genetic characteristics remain underexplored. Therefore, the whole genome of C. acnes CN6, an SLST D1 strain isolated from the facial skin of a healthy individual, was sequenced to expand the understanding of SLST D1 strains and identify genomic features that may support skin health. Data description The whole genome sequencing of C. acnes CN6 was conducted using MinION reads based on de novo assembly, revealing a single circular complete chromosome. With the length of 2,550,458 bp and G + C content of 60.04%, the genome contains 2,492 genes, including 2,433 CDSs, 9 rRNAs, 46 tRNAs, 4 ncRNAs, and 134 pseudo genes. Previously predicted virulence proteins of C. ances were detected in the genome. Genome comparation with 200 C. acnes strains isolated from healthy facial skin revealed SLST D1 strain-specific genes and a unique variant of the znuC gene in D1 strains.https://doi.org/10.1186/s12863-024-01277-zCutibacterium acnesSingle-locus sequence typing (SLST)Healthy skinWhole genome sequencingDe novo assembly |
| spellingShingle | Ikwhan Kim Da-Ryung Jung Ryeong-Hui Kim Dokyung Lee YeonGyun Jung Ji Hoon Ha Eun Kyung Lee Jin Mo Kim Jin Young Kim Jun-Hwan Jang Jun-Tae Bae Yoon Soo Cho Jae-Ho Shin Complete genome of single locus sequence typing D1 strain Cutibacterium acnes CN6 isolated from healthy facial skin BMC Genomic Data Cutibacterium acnes Single-locus sequence typing (SLST) Healthy skin Whole genome sequencing De novo assembly |
| title | Complete genome of single locus sequence typing D1 strain Cutibacterium acnes CN6 isolated from healthy facial skin |
| title_full | Complete genome of single locus sequence typing D1 strain Cutibacterium acnes CN6 isolated from healthy facial skin |
| title_fullStr | Complete genome of single locus sequence typing D1 strain Cutibacterium acnes CN6 isolated from healthy facial skin |
| title_full_unstemmed | Complete genome of single locus sequence typing D1 strain Cutibacterium acnes CN6 isolated from healthy facial skin |
| title_short | Complete genome of single locus sequence typing D1 strain Cutibacterium acnes CN6 isolated from healthy facial skin |
| title_sort | complete genome of single locus sequence typing d1 strain cutibacterium acnes cn6 isolated from healthy facial skin |
| topic | Cutibacterium acnes Single-locus sequence typing (SLST) Healthy skin Whole genome sequencing De novo assembly |
| url | https://doi.org/10.1186/s12863-024-01277-z |
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