Brain local structural connectomes and the subtypes of the medial temporal lobe parcellations
ObjectiveTo investigate the quantitative characteristics and major subtypes of local structural connectomes for medial temporal lobe (MTL) parcellations.MethodsThe Q-Space Diffeomorphic Reconstruction (QSDR) method was used to track white matter fibers for the ROIs within MTL based on the integratin...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2025.1529123/full |
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| author | Zhensheng Li Jie Ma Hongmin Bai Bingmei Deng Jian Lin Weimin Wang |
| author_facet | Zhensheng Li Jie Ma Hongmin Bai Bingmei Deng Jian Lin Weimin Wang |
| author_sort | Zhensheng Li |
| collection | DOAJ |
| description | ObjectiveTo investigate the quantitative characteristics and major subtypes of local structural connectomes for medial temporal lobe (MTL) parcellations.MethodsThe Q-Space Diffeomorphic Reconstruction (QSDR) method was used to track white matter fibers for the ROIs within MTL based on the integrating high-resolution T1 structural MR imaging and diffusion MR imaging of 100 adult Chinese individuals. Graph theoretical analysis was employed to construct the local structural connectome models for ROIs within MTL and acquire the network parameters. These connectivity matrices of these connectomes were classified into major subtypes undergoing hierarchical clustering.Results(1) In the local brain connectomes, the overall network features exhibited a low characteristic path length paired with moderate to high global efficiency, suggesting the effectiveness of the local brain connectome construction. The amygdala connectomes exhibited longer characteristic path length and weaker global efficiency than the ipsilateral hippocampus and parahippocampal connectomes. (2) The hubs of the amygdala connectomes were dispersed across the ventral frontal, olfactory area, limbic, parietal regions and subcortical nuclei, and the hubs the hippocampal connectomes were mainly situated within the limbic, parietal, and subcortical regions. The hubs distribution of the parahippocampal connectomes resembled the hippocampal structural connectomes, but lacking interhemispheric connections and connectivity with subcortical nuclei. (3) The subtypes of the brain local structural connectomes for each ROI were classified by hierarchical clustering, The subtypes of the bilateral amygdala connectomes were the amygdala-prefrontal connectome; the amygdala-ipsilateral or contralateral limbic connectome and the amygdala-posterior connectome. The subtypes of the bilateral hippocampal connectomes primarily included the hippocampus-ipsilateral or contralateral limbic connectome and the anterior temporal-hippocampus-ventral temporal-occipital connectome in the domain hemisphere. The subtypes of the parahippocampal connectomes exhibited resemblances to those of the hippocampus.ConclusionWe have constructed the brain local connectomes of the MTL parcellations and acquired the network parameters to delineate the hubs distribution through graph theory analysis. The connectomes can be classified into different major subtypes, which were closely related to the functional connectivity. |
| format | Article |
| id | doaj-art-c9cb8c387573491a91e6a77176c82734 |
| institution | Kabale University |
| issn | 1662-453X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neuroscience |
| spelling | doaj-art-c9cb8c387573491a91e6a77176c827342025-02-12T07:26:34ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2025-02-011910.3389/fnins.2025.15291231529123Brain local structural connectomes and the subtypes of the medial temporal lobe parcellationsZhensheng Li0Jie Ma1Hongmin Bai2Bingmei Deng3Jian Lin4Weimin Wang5Department of Neurology, General Hospital of Southern Theater Command, Guangzhou, ChinaDepartment of Neurosurgery, Chinese PLA General Hospital, Beijing, ChinaDepartment of Neurosurgery, General Hospital of Southern Theater Command, Guangzhou, ChinaDepartment of Neurology, General Hospital of Southern Theater Command, Guangzhou, ChinaDepartment of Neurosurgery, General Hospital of Southern Theater Command, Guangzhou, ChinaDepartment of Neurosurgery, General Hospital of Southern Theater Command, Guangzhou, ChinaObjectiveTo investigate the quantitative characteristics and major subtypes of local structural connectomes for medial temporal lobe (MTL) parcellations.MethodsThe Q-Space Diffeomorphic Reconstruction (QSDR) method was used to track white matter fibers for the ROIs within MTL based on the integrating high-resolution T1 structural MR imaging and diffusion MR imaging of 100 adult Chinese individuals. Graph theoretical analysis was employed to construct the local structural connectome models for ROIs within MTL and acquire the network parameters. These connectivity matrices of these connectomes were classified into major subtypes undergoing hierarchical clustering.Results(1) In the local brain connectomes, the overall network features exhibited a low characteristic path length paired with moderate to high global efficiency, suggesting the effectiveness of the local brain connectome construction. The amygdala connectomes exhibited longer characteristic path length and weaker global efficiency than the ipsilateral hippocampus and parahippocampal connectomes. (2) The hubs of the amygdala connectomes were dispersed across the ventral frontal, olfactory area, limbic, parietal regions and subcortical nuclei, and the hubs the hippocampal connectomes were mainly situated within the limbic, parietal, and subcortical regions. The hubs distribution of the parahippocampal connectomes resembled the hippocampal structural connectomes, but lacking interhemispheric connections and connectivity with subcortical nuclei. (3) The subtypes of the brain local structural connectomes for each ROI were classified by hierarchical clustering, The subtypes of the bilateral amygdala connectomes were the amygdala-prefrontal connectome; the amygdala-ipsilateral or contralateral limbic connectome and the amygdala-posterior connectome. The subtypes of the bilateral hippocampal connectomes primarily included the hippocampus-ipsilateral or contralateral limbic connectome and the anterior temporal-hippocampus-ventral temporal-occipital connectome in the domain hemisphere. The subtypes of the parahippocampal connectomes exhibited resemblances to those of the hippocampus.ConclusionWe have constructed the brain local connectomes of the MTL parcellations and acquired the network parameters to delineate the hubs distribution through graph theory analysis. The connectomes can be classified into different major subtypes, which were closely related to the functional connectivity.https://www.frontiersin.org/articles/10.3389/fnins.2025.1529123/fullbrain connectomelocal structural connectomemedial temporal lobebrain connectivitylocal connectivity |
| spellingShingle | Zhensheng Li Jie Ma Hongmin Bai Bingmei Deng Jian Lin Weimin Wang Brain local structural connectomes and the subtypes of the medial temporal lobe parcellations Frontiers in Neuroscience brain connectome local structural connectome medial temporal lobe brain connectivity local connectivity |
| title | Brain local structural connectomes and the subtypes of the medial temporal lobe parcellations |
| title_full | Brain local structural connectomes and the subtypes of the medial temporal lobe parcellations |
| title_fullStr | Brain local structural connectomes and the subtypes of the medial temporal lobe parcellations |
| title_full_unstemmed | Brain local structural connectomes and the subtypes of the medial temporal lobe parcellations |
| title_short | Brain local structural connectomes and the subtypes of the medial temporal lobe parcellations |
| title_sort | brain local structural connectomes and the subtypes of the medial temporal lobe parcellations |
| topic | brain connectome local structural connectome medial temporal lobe brain connectivity local connectivity |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2025.1529123/full |
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