Herpes Simplex virus type 2 seroprevalence and risk factors among adolescents and youth with HIV-1 in Northern, Tanzania
Introduction: Herpes Simplex virus type 2 (HSV-2) infection is associated with an increased risk of human immunodeficiency virus type 1 (HIV-1) acquisition and transmission. Individuals co-infected with HIV-1 and HSV-2 may have longer lasting, more frequent and severe outbreaks of herpes symptoms....
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The Journal of Infection in Developing Countries
2020-04-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/11599 |
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| author | Rashid Madebe Ireen Kiwelu Arnold Ndaro Filbert Francis Vito Baraka Zahra Theilgaard Terese Katzenstein |
| author_facet | Rashid Madebe Ireen Kiwelu Arnold Ndaro Filbert Francis Vito Baraka Zahra Theilgaard Terese Katzenstein |
| author_sort | Rashid Madebe |
| collection | DOAJ |
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Introduction: Herpes Simplex virus type 2 (HSV-2) infection is associated with an increased risk of human immunodeficiency virus type 1 (HIV-1) acquisition and transmission. Individuals co-infected with HIV-1 and HSV-2 may have longer lasting, more frequent and severe outbreaks of herpes symptoms. Previous studies have assessed HSV-2 seroprevalence and associated risk factors in adult populations. However, there is limited data on the HSV-2 seroprevalence among adolescents and youth living with HIV-1. The study aimed to determine the HSV-2 seroprevalence and associated risk factors among adolescents and youth living with HIV-1 at referral hospital setting in Northern Tanzania.
Methodology: A cross-sectional survey was conducted between February and July 2017 among HIV-1-infected individuals aged 10-24 years attending the Child -Centred Family Care Clinic at Kilimanjaro Christian Medical Centre. Blood specimens from 180 individuals were collected for ELISA-based detection of HSV-2 antibodies. Associations between risk factors and HSV-2 seroprevalence were analysed by univariate and multivariate logistic regression models.
Results: The overall HSV-2 seroprevalence was 18% (32/180). A significant HSV-2 seroprevalence was noted among adolescents and youth, who reported having had sexual intercourse than those who never had sexual intercourse (28.9% vs 13.3%, p = 0.02). Youths aged 20-24 had six folds higher risk of HSV-2 seroprevalence compared to those aged 10-14 years (AOR = 5.97 95% CI 1.31 – 27.19, p = 0.02).
Conclusions: Our study found that HSV-2 seroprevalence increased by age among adolescents and youth living with HIV-1. Age-specific approaches might play an important role in interventions targeting HSV-2 infection.
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| format | Article |
| id | doaj-art-c9cb688db4bf43c3937c8ceb378797ef |
| institution | OA Journals |
| issn | 1972-2680 |
| language | English |
| publishDate | 2020-04-01 |
| publisher | The Journal of Infection in Developing Countries |
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| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-c9cb688db4bf43c3937c8ceb378797ef2025-08-20T02:27:20ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802020-04-01140410.3855/jidc.11599Herpes Simplex virus type 2 seroprevalence and risk factors among adolescents and youth with HIV-1 in Northern, TanzaniaRashid Madebe0Ireen Kiwelu1Arnold Ndaro2Filbert Francis3Vito Baraka4Zahra Theilgaard5Terese Katzenstein6Kilimanjaro Christian Medical University College, Moshi, TanzaniaKilimanjaro Christian Medical University College, Moshi, TanzaniaKilimanjaro Christian Medical Centre, Moshi, TanzaniaNational Institute for Medical Research, Tanga Centre, TanzaniaNational Institute for Medical Research, Tanga Centre, TanzaniaCopenhagen University Hospital, Rigshospitalet, Copenhagen, DenmarkCopenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark Introduction: Herpes Simplex virus type 2 (HSV-2) infection is associated with an increased risk of human immunodeficiency virus type 1 (HIV-1) acquisition and transmission. Individuals co-infected with HIV-1 and HSV-2 may have longer lasting, more frequent and severe outbreaks of herpes symptoms. Previous studies have assessed HSV-2 seroprevalence and associated risk factors in adult populations. However, there is limited data on the HSV-2 seroprevalence among adolescents and youth living with HIV-1. The study aimed to determine the HSV-2 seroprevalence and associated risk factors among adolescents and youth living with HIV-1 at referral hospital setting in Northern Tanzania. Methodology: A cross-sectional survey was conducted between February and July 2017 among HIV-1-infected individuals aged 10-24 years attending the Child -Centred Family Care Clinic at Kilimanjaro Christian Medical Centre. Blood specimens from 180 individuals were collected for ELISA-based detection of HSV-2 antibodies. Associations between risk factors and HSV-2 seroprevalence were analysed by univariate and multivariate logistic regression models. Results: The overall HSV-2 seroprevalence was 18% (32/180). A significant HSV-2 seroprevalence was noted among adolescents and youth, who reported having had sexual intercourse than those who never had sexual intercourse (28.9% vs 13.3%, p = 0.02). Youths aged 20-24 had six folds higher risk of HSV-2 seroprevalence compared to those aged 10-14 years (AOR = 5.97 95% CI 1.31 – 27.19, p = 0.02). Conclusions: Our study found that HSV-2 seroprevalence increased by age among adolescents and youth living with HIV-1. Age-specific approaches might play an important role in interventions targeting HSV-2 infection. https://jidc.org/index.php/journal/article/view/11599Herpes simplex virus type 2human immunodeficiency virusadolescentsyouthTanzania |
| spellingShingle | Rashid Madebe Ireen Kiwelu Arnold Ndaro Filbert Francis Vito Baraka Zahra Theilgaard Terese Katzenstein Herpes Simplex virus type 2 seroprevalence and risk factors among adolescents and youth with HIV-1 in Northern, Tanzania Journal of Infection in Developing Countries Herpes simplex virus type 2 human immunodeficiency virus adolescents youth Tanzania |
| title | Herpes Simplex virus type 2 seroprevalence and risk factors among adolescents and youth with HIV-1 in Northern, Tanzania |
| title_full | Herpes Simplex virus type 2 seroprevalence and risk factors among adolescents and youth with HIV-1 in Northern, Tanzania |
| title_fullStr | Herpes Simplex virus type 2 seroprevalence and risk factors among adolescents and youth with HIV-1 in Northern, Tanzania |
| title_full_unstemmed | Herpes Simplex virus type 2 seroprevalence and risk factors among adolescents and youth with HIV-1 in Northern, Tanzania |
| title_short | Herpes Simplex virus type 2 seroprevalence and risk factors among adolescents and youth with HIV-1 in Northern, Tanzania |
| title_sort | herpes simplex virus type 2 seroprevalence and risk factors among adolescents and youth with hiv 1 in northern tanzania |
| topic | Herpes simplex virus type 2 human immunodeficiency virus adolescents youth Tanzania |
| url | https://jidc.org/index.php/journal/article/view/11599 |
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