Multimodal dataset linking wide‐field calcium imaging to behavior changes in operant lever‐pull task in mice
Abstract The link between comprehensive behavioral measurements during a behavioral task and brain-wide neuronal activity is an essential strategy to better understand the brain dynamics underlying the emergence of behavior changes. To tackle this, we provide an extensive, multimodal dataset that in...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-07-01
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| Series: | Scientific Data |
| Online Access: | https://doi.org/10.1038/s41597-025-05482-y |
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| author | Masashi Kondo Keisuke Sehara Rie Harukuni Ryo Aoki Shoya Sugimoto Yasuhiro R. Tanaka Masanori Matsuzaki Ken Nakae |
| author_facet | Masashi Kondo Keisuke Sehara Rie Harukuni Ryo Aoki Shoya Sugimoto Yasuhiro R. Tanaka Masanori Matsuzaki Ken Nakae |
| author_sort | Masashi Kondo |
| collection | DOAJ |
| description | Abstract The link between comprehensive behavioral measurements during a behavioral task and brain-wide neuronal activity is an essential strategy to better understand the brain dynamics underlying the emergence of behavior changes. To tackle this, we provide an extensive, multimodal dataset that includes 15 sessions spanning 2 weeks of motor skill learning, in which 25 mice were trained to pull a lever to obtain water rewards. Simultaneous high-speed videography captured body, facial, and eye movements, and environmental parameters were monitored. The dataset also features resting-state cortical activity and sensory-evoked responses, enhancing its utility for both learning-related and sensory-driven neural dynamics studies. Data are formatted in accordance with the Neurodata Without Borders (NWB) standard, ensuring compatibility with existing analysis tools and adherence to the FAIR principles (Findable, Accessible, Interoperable, Reusable). This resource enables in-depth investigations into the neural mechanisms underlying behavior and learning. The platform encourages collaborative research, supporting the exploration of rapid within-session learning effects, long-term behavioral adaptations, and neural circuit dynamics. |
| format | Article |
| id | doaj-art-c9ca90bcf3774abeb3f69e5147a45a28 |
| institution | Kabale University |
| issn | 2052-4463 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Data |
| spelling | doaj-art-c9ca90bcf3774abeb3f69e5147a45a282025-08-20T03:45:45ZengNature PortfolioScientific Data2052-44632025-07-0112111710.1038/s41597-025-05482-yMultimodal dataset linking wide‐field calcium imaging to behavior changes in operant lever‐pull task in miceMasashi Kondo0Keisuke Sehara1Rie Harukuni2Ryo Aoki3Shoya Sugimoto4Yasuhiro R. Tanaka5Masanori Matsuzaki6Ken Nakae7Department of Physiology, Graduate School of Medicine, The University of TokyoDepartment of Physiology, Graduate School of Medicine, The University of TokyoDepartment of Physiology, Graduate School of Medicine, The University of TokyoBrain Science Institute, Tamagawa UniversityBrain Science Institute, Tamagawa UniversityBrain Science Institute, Tamagawa UniversityDepartment of Physiology, Graduate School of Medicine, The University of TokyoExploratory Research Center on Life and Living Systems, National Institutes of Natural SciencesAbstract The link between comprehensive behavioral measurements during a behavioral task and brain-wide neuronal activity is an essential strategy to better understand the brain dynamics underlying the emergence of behavior changes. To tackle this, we provide an extensive, multimodal dataset that includes 15 sessions spanning 2 weeks of motor skill learning, in which 25 mice were trained to pull a lever to obtain water rewards. Simultaneous high-speed videography captured body, facial, and eye movements, and environmental parameters were monitored. The dataset also features resting-state cortical activity and sensory-evoked responses, enhancing its utility for both learning-related and sensory-driven neural dynamics studies. Data are formatted in accordance with the Neurodata Without Borders (NWB) standard, ensuring compatibility with existing analysis tools and adherence to the FAIR principles (Findable, Accessible, Interoperable, Reusable). This resource enables in-depth investigations into the neural mechanisms underlying behavior and learning. The platform encourages collaborative research, supporting the exploration of rapid within-session learning effects, long-term behavioral adaptations, and neural circuit dynamics.https://doi.org/10.1038/s41597-025-05482-y |
| spellingShingle | Masashi Kondo Keisuke Sehara Rie Harukuni Ryo Aoki Shoya Sugimoto Yasuhiro R. Tanaka Masanori Matsuzaki Ken Nakae Multimodal dataset linking wide‐field calcium imaging to behavior changes in operant lever‐pull task in mice Scientific Data |
| title | Multimodal dataset linking wide‐field calcium imaging to behavior changes in operant lever‐pull task in mice |
| title_full | Multimodal dataset linking wide‐field calcium imaging to behavior changes in operant lever‐pull task in mice |
| title_fullStr | Multimodal dataset linking wide‐field calcium imaging to behavior changes in operant lever‐pull task in mice |
| title_full_unstemmed | Multimodal dataset linking wide‐field calcium imaging to behavior changes in operant lever‐pull task in mice |
| title_short | Multimodal dataset linking wide‐field calcium imaging to behavior changes in operant lever‐pull task in mice |
| title_sort | multimodal dataset linking wide field calcium imaging to behavior changes in operant lever pull task in mice |
| url | https://doi.org/10.1038/s41597-025-05482-y |
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