Impaired sensitivity to thyroid hormones is associated with increased body fat mass/muscle mass ratio (F/M) in the euthyroid population
Abstract Objective To explore the relationship between body fat mass/muscle mass ratio (F/M) and thyroid hormone sensitivity in the euthyroid population. Methods Body compositions of 845 check-up individuals were determined using bioelectrical impedance analysis (BIA). Biochemical indexes including...
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BMC
2025-04-01
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| Series: | Diabetology & Metabolic Syndrome |
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| Online Access: | https://doi.org/10.1186/s13098-025-01693-w |
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| author | Ying Li Qianqian Zhang Li Chen Yue Wang Qibao Ye Wei Liu Yan Liu Guojuan Wang |
| author_facet | Ying Li Qianqian Zhang Li Chen Yue Wang Qibao Ye Wei Liu Yan Liu Guojuan Wang |
| author_sort | Ying Li |
| collection | DOAJ |
| description | Abstract Objective To explore the relationship between body fat mass/muscle mass ratio (F/M) and thyroid hormone sensitivity in the euthyroid population. Methods Body compositions of 845 check-up individuals were determined using bioelectrical impedance analysis (BIA). Biochemical indexes including blood glucose, blood lipids, liver and kidney functions and thyrotropic hormones (THs) were detected. Free triiodothyronine to free thyroxine ratio (FT3/FT4), Thyroid Feedback Quantile-based Index (TFQI), Thyrotropin Thyroxine Resistance Index (TT4RI) and TSH Index (TSHI) were calculated for analysis. Results TT4RI and TSHI showed increased trends with statistical difference, while FT3/FT4 and TFQI showed no difference among F/M quartile groups. After adjusting for confounding factors, F/M exhibited no correlation with FT3/FT4, but positive correlations with TFQI, TT4RI and TSHI. Gender subgroup analysis showed that F/M exhibited positive relationship with TFQI in females; exhibited positive correlations with TFQI, TT4RI and TSHI before the inflection points, but no correlations thereafter in males. Age subgroup analysis showed that F/M exhibited positive correlations with TFQI, TT4RI and TSHI, but no correlation with FT3/FT4 in age < 65 years group; exhibited no relationship with thyroid hormone sensitivity in age ≥ 65 years group. BMI subgroup analysis showed that F/M exhibited no relationship with thyroid hormone sensitivity in BMI < 25 kg/m2 group; exhibited positive correlations with TFQI, TT4RI and TSHI before the inflection points, but no correlations thereafter in BMI ≥ 25, < 30 kg/m2 group; exhibited positive correlation with TFQI before the inflection point, but no correlation thereafter in BMI ≥ 30 kg/m2 group; exhibited no correlations with TT4RI and TSHI before the inflection points, but negative correlations with them thereafter in BMI ≥ 30 kg/m2 group. Conclusion Impaired central, but not peripheral sensitivity to thyroid hormones was associated with increased body fat mass/muscle mass ratio (F/M), this association was obvious in males, individuals with age < 65 years and BMI ≥ 25 kg/m2, with different inflection points. Maybe F/M independently affects thyroid hormone sensitivity, we need more clinical and basic studies in the future. |
| format | Article |
| id | doaj-art-c9c74e4cbbe946f792bf427ebfa8a59e |
| institution | OA Journals |
| issn | 1758-5996 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
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| series | Diabetology & Metabolic Syndrome |
| spelling | doaj-art-c9c74e4cbbe946f792bf427ebfa8a59e2025-08-20T02:28:10ZengBMCDiabetology & Metabolic Syndrome1758-59962025-04-0117111410.1186/s13098-025-01693-wImpaired sensitivity to thyroid hormones is associated with increased body fat mass/muscle mass ratio (F/M) in the euthyroid populationYing Li0Qianqian Zhang1Li Chen2Yue Wang3Qibao Ye4Wei Liu5Yan Liu6Guojuan Wang7Department of Endocrinology, The First People’s Hospital of HefeiDepartment of Endocrinology, The First People’s Hospital of HefeiDepartment of Endocrinology, The First People’s Hospital of HefeiDepartment of Endocrinology, The Second Affiliated Hospital of Anhui Medical UniversityDepartment of Endocrinology, The First People’s Hospital of HefeiLaboratory Department, The First People’s Hospital of HefeiDepartment of Physical Examination Center, The First People’s Hospital of HefeiDepartment of Endocrinology, The First People’s Hospital of HefeiAbstract Objective To explore the relationship between body fat mass/muscle mass ratio (F/M) and thyroid hormone sensitivity in the euthyroid population. Methods Body compositions of 845 check-up individuals were determined using bioelectrical impedance analysis (BIA). Biochemical indexes including blood glucose, blood lipids, liver and kidney functions and thyrotropic hormones (THs) were detected. Free triiodothyronine to free thyroxine ratio (FT3/FT4), Thyroid Feedback Quantile-based Index (TFQI), Thyrotropin Thyroxine Resistance Index (TT4RI) and TSH Index (TSHI) were calculated for analysis. Results TT4RI and TSHI showed increased trends with statistical difference, while FT3/FT4 and TFQI showed no difference among F/M quartile groups. After adjusting for confounding factors, F/M exhibited no correlation with FT3/FT4, but positive correlations with TFQI, TT4RI and TSHI. Gender subgroup analysis showed that F/M exhibited positive relationship with TFQI in females; exhibited positive correlations with TFQI, TT4RI and TSHI before the inflection points, but no correlations thereafter in males. Age subgroup analysis showed that F/M exhibited positive correlations with TFQI, TT4RI and TSHI, but no correlation with FT3/FT4 in age < 65 years group; exhibited no relationship with thyroid hormone sensitivity in age ≥ 65 years group. BMI subgroup analysis showed that F/M exhibited no relationship with thyroid hormone sensitivity in BMI < 25 kg/m2 group; exhibited positive correlations with TFQI, TT4RI and TSHI before the inflection points, but no correlations thereafter in BMI ≥ 25, < 30 kg/m2 group; exhibited positive correlation with TFQI before the inflection point, but no correlation thereafter in BMI ≥ 30 kg/m2 group; exhibited no correlations with TT4RI and TSHI before the inflection points, but negative correlations with them thereafter in BMI ≥ 30 kg/m2 group. Conclusion Impaired central, but not peripheral sensitivity to thyroid hormones was associated with increased body fat mass/muscle mass ratio (F/M), this association was obvious in males, individuals with age < 65 years and BMI ≥ 25 kg/m2, with different inflection points. Maybe F/M independently affects thyroid hormone sensitivity, we need more clinical and basic studies in the future.https://doi.org/10.1186/s13098-025-01693-wBody fat mass/muscle mass ratioFree triiodothyronine to free thyroxineThyroid feedback quantile-based IndexThyrotropin thyroxine resistance indexTSH index |
| spellingShingle | Ying Li Qianqian Zhang Li Chen Yue Wang Qibao Ye Wei Liu Yan Liu Guojuan Wang Impaired sensitivity to thyroid hormones is associated with increased body fat mass/muscle mass ratio (F/M) in the euthyroid population Diabetology & Metabolic Syndrome Body fat mass/muscle mass ratio Free triiodothyronine to free thyroxine Thyroid feedback quantile-based Index Thyrotropin thyroxine resistance index TSH index |
| title | Impaired sensitivity to thyroid hormones is associated with increased body fat mass/muscle mass ratio (F/M) in the euthyroid population |
| title_full | Impaired sensitivity to thyroid hormones is associated with increased body fat mass/muscle mass ratio (F/M) in the euthyroid population |
| title_fullStr | Impaired sensitivity to thyroid hormones is associated with increased body fat mass/muscle mass ratio (F/M) in the euthyroid population |
| title_full_unstemmed | Impaired sensitivity to thyroid hormones is associated with increased body fat mass/muscle mass ratio (F/M) in the euthyroid population |
| title_short | Impaired sensitivity to thyroid hormones is associated with increased body fat mass/muscle mass ratio (F/M) in the euthyroid population |
| title_sort | impaired sensitivity to thyroid hormones is associated with increased body fat mass muscle mass ratio f m in the euthyroid population |
| topic | Body fat mass/muscle mass ratio Free triiodothyronine to free thyroxine Thyroid feedback quantile-based Index Thyrotropin thyroxine resistance index TSH index |
| url | https://doi.org/10.1186/s13098-025-01693-w |
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