The amelioration effect of sesamoside on inflammatory response in septic shock
Abstract Sepsis shock is caused by a systemic infection characterized by circulatory disorders and metabolic abnormalities. Microorganisms or their toxins enter the bloodstream, releasing inflammatory mediators and triggering systemic inflammatory reactions, leading to multiple organ dysfunction and...
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| Language: | English |
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BMC
2025-03-01
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| Series: | BMC Immunology |
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| Online Access: | https://doi.org/10.1186/s12865-025-00695-7 |
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| author | Dan Song Xinjie Zhao Yanru Zhang Mengjie Wang Haojie Tang Jing Fang Zhuoyang Song Qingyang Ma Jing Geng |
| author_facet | Dan Song Xinjie Zhao Yanru Zhang Mengjie Wang Haojie Tang Jing Fang Zhuoyang Song Qingyang Ma Jing Geng |
| author_sort | Dan Song |
| collection | DOAJ |
| description | Abstract Sepsis shock is caused by a systemic infection characterized by circulatory disorders and metabolic abnormalities. Microorganisms or their toxins enter the bloodstream, releasing inflammatory mediators and triggering systemic inflammatory reactions, leading to multiple organ dysfunction and even failure. To explore new treatment methods, we studied the improvement effect of sesamoside on the inflammatory response in septic shock. We performed in vitro experiments and animal models. We found that sesamoside reduced inflammatory cytokines such as TNF-α, IL-6, IL-1β, iNOS, and NO. Sesamoside inhibited the LPS-induced phosphorylation of ERK and JNK and downregulated the expression of NLRP3, reducing the systemic inflammatory response. In addition, sesamoside reduces multi-organ injuries in LPS-induced septic shock and restricts the nuclear localization of P65 to regulate the immune response, enhance immune function, and help restore cell metabolism and organ function. This study reveals the improved effect of sesamoside on inflammatory response in septic shock, providing new ideas and methods for treating septic shock. Future research will explore the mechanism of action of sesamoside and its clinical application value in the treatment of septic shock. Clinical trial number: Not applicable. |
| format | Article |
| id | doaj-art-c9c4e89c3bb6432896565e5269a6a174 |
| institution | DOAJ |
| issn | 1471-2172 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Immunology |
| spelling | doaj-art-c9c4e89c3bb6432896565e5269a6a1742025-08-20T03:05:57ZengBMCBMC Immunology1471-21722025-03-0126111210.1186/s12865-025-00695-7The amelioration effect of sesamoside on inflammatory response in septic shockDan Song0Xinjie Zhao1Yanru Zhang2Mengjie Wang3Haojie Tang4Jing Fang5Zhuoyang Song6Qingyang Ma7Jing Geng8Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu UniversityKey Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu UniversityKey Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu UniversityKey Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu UniversityKey Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu UniversityKey Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu UniversityKey Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu UniversityKey Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu UniversityNational and Local Joint Engineering Research Center of Biodiagnosis and Biotherapy, The Second Affiliated Hospital of Xi’an Jiaotong UniversityAbstract Sepsis shock is caused by a systemic infection characterized by circulatory disorders and metabolic abnormalities. Microorganisms or their toxins enter the bloodstream, releasing inflammatory mediators and triggering systemic inflammatory reactions, leading to multiple organ dysfunction and even failure. To explore new treatment methods, we studied the improvement effect of sesamoside on the inflammatory response in septic shock. We performed in vitro experiments and animal models. We found that sesamoside reduced inflammatory cytokines such as TNF-α, IL-6, IL-1β, iNOS, and NO. Sesamoside inhibited the LPS-induced phosphorylation of ERK and JNK and downregulated the expression of NLRP3, reducing the systemic inflammatory response. In addition, sesamoside reduces multi-organ injuries in LPS-induced septic shock and restricts the nuclear localization of P65 to regulate the immune response, enhance immune function, and help restore cell metabolism and organ function. This study reveals the improved effect of sesamoside on inflammatory response in septic shock, providing new ideas and methods for treating septic shock. Future research will explore the mechanism of action of sesamoside and its clinical application value in the treatment of septic shock. Clinical trial number: Not applicable.https://doi.org/10.1186/s12865-025-00695-7SesamosideSeptic shockInflammatory responseOrgan injury |
| spellingShingle | Dan Song Xinjie Zhao Yanru Zhang Mengjie Wang Haojie Tang Jing Fang Zhuoyang Song Qingyang Ma Jing Geng The amelioration effect of sesamoside on inflammatory response in septic shock BMC Immunology Sesamoside Septic shock Inflammatory response Organ injury |
| title | The amelioration effect of sesamoside on inflammatory response in septic shock |
| title_full | The amelioration effect of sesamoside on inflammatory response in septic shock |
| title_fullStr | The amelioration effect of sesamoside on inflammatory response in septic shock |
| title_full_unstemmed | The amelioration effect of sesamoside on inflammatory response in septic shock |
| title_short | The amelioration effect of sesamoside on inflammatory response in septic shock |
| title_sort | amelioration effect of sesamoside on inflammatory response in septic shock |
| topic | Sesamoside Septic shock Inflammatory response Organ injury |
| url | https://doi.org/10.1186/s12865-025-00695-7 |
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