Mesenteric and splenic venous thrombosis in a female patient with essential thrombocytosis and the resistance to activated protein C
Splenic venous thrombosis is a rare disease in which an underlying hypercoagulable state can often be found. A 27-years old female patient with recurrent mesenteric venous and splenic thrombosis as a severe complication of an association of resistance to activated protein C and essential thrombocyth...
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| Format: | Article |
| Language: | English |
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2003-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2003/0042-84500302227M.pdf |
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| author | Marisavljević Dragomir Elezović Ivo V. Bilanović Dragoljub Petrović Nataša Janjić Mirjana Šefer Dijana |
| author_facet | Marisavljević Dragomir Elezović Ivo V. Bilanović Dragoljub Petrović Nataša Janjić Mirjana Šefer Dijana |
| author_sort | Marisavljević Dragomir |
| collection | DOAJ |
| description | Splenic venous thrombosis is a rare disease in which an underlying hypercoagulable state can often be found. A 27-years old female patient with recurrent mesenteric venous and splenic thrombosis as a severe complication of an association of resistance to activated protein C and essential thrombocythemia is presented in this report. Establishing the diagnosis of essential thrombocytosis was particularly difficult because this was the case of the so called "silent" myeloproliferative disorder. The number of thrombocytes was almost normal before the splenectomy performed because of the splenic venous thrombosis. Thus, spontaneous growth of erythroid and megakaryocyte colonies in vitro and the clinical course of the disease were the clues for establishing the diagnosis, because the number of thrombocytes reached the values over 1500×109/l after only 1.5 years of the follow-up. The case of this patient was interesting particularly from the surgical point of view because of the management strategy. |
| format | Article |
| id | doaj-art-c9c4e18770e5484a9b42441c95e9adc1 |
| institution | DOAJ |
| issn | 0042-8450 |
| language | English |
| publishDate | 2003-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-c9c4e18770e5484a9b42441c95e9adc12025-08-20T03:05:05ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502003-01-0160222723110.2298/VSP0302227MMesenteric and splenic venous thrombosis in a female patient with essential thrombocytosis and the resistance to activated protein CMarisavljević DragomirElezović Ivo V.Bilanović DragoljubPetrović NatašaJanjić MirjanaŠefer DijanaSplenic venous thrombosis is a rare disease in which an underlying hypercoagulable state can often be found. A 27-years old female patient with recurrent mesenteric venous and splenic thrombosis as a severe complication of an association of resistance to activated protein C and essential thrombocythemia is presented in this report. Establishing the diagnosis of essential thrombocytosis was particularly difficult because this was the case of the so called "silent" myeloproliferative disorder. The number of thrombocytes was almost normal before the splenectomy performed because of the splenic venous thrombosis. Thus, spontaneous growth of erythroid and megakaryocyte colonies in vitro and the clinical course of the disease were the clues for establishing the diagnosis, because the number of thrombocytes reached the values over 1500×109/l after only 1.5 years of the follow-up. The case of this patient was interesting particularly from the surgical point of view because of the management strategy.http://www.doiserbia.nb.rs/img/doi/0042-8450/2003/0042-84500302227M.pdfthrombosismesenteric veinssplenic veinthrombocytosisthrombophiliaactivated protein C resistanceblood platelets |
| spellingShingle | Marisavljević Dragomir Elezović Ivo V. Bilanović Dragoljub Petrović Nataša Janjić Mirjana Šefer Dijana Mesenteric and splenic venous thrombosis in a female patient with essential thrombocytosis and the resistance to activated protein C Vojnosanitetski Pregled thrombosis mesenteric veins splenic vein thrombocytosis thrombophilia activated protein C resistance blood platelets |
| title | Mesenteric and splenic venous thrombosis in a female patient with essential thrombocytosis and the resistance to activated protein C |
| title_full | Mesenteric and splenic venous thrombosis in a female patient with essential thrombocytosis and the resistance to activated protein C |
| title_fullStr | Mesenteric and splenic venous thrombosis in a female patient with essential thrombocytosis and the resistance to activated protein C |
| title_full_unstemmed | Mesenteric and splenic venous thrombosis in a female patient with essential thrombocytosis and the resistance to activated protein C |
| title_short | Mesenteric and splenic venous thrombosis in a female patient with essential thrombocytosis and the resistance to activated protein C |
| title_sort | mesenteric and splenic venous thrombosis in a female patient with essential thrombocytosis and the resistance to activated protein c |
| topic | thrombosis mesenteric veins splenic vein thrombocytosis thrombophilia activated protein C resistance blood platelets |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2003/0042-84500302227M.pdf |
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