Spatiotemporal perturbations of the plasminogen activation system in a rat model of acute organophosphate intoxication

Abstract Neuroinflammation is widely posited to be a key pathogenic mechanism linking acute organophosphate (OP)-induced status epilepticus (SE) to persistent brain injury and abnormal electrical activity that contribute to epilepsy and cognitive impairment. The plasminogen activation system (PAS) p...

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Main Authors: Thomas J. Blackmon, Jeremy A. MacMahon, Pedro N. Bernardino, Ryan E. Hogans, Mei-Yun Cheng, Joan Vu, Ruth Diana Lee, Naomi H. Saito, Ana Cristina Grodzki, Donald A. Bruun, Heike Wulff, Kevin D. Woolard, Amy Brooks-Kayal, Danielle J. Harvey, Fredric A. Gorin, Pamela J. Lein
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Acta Neuropathologica Communications
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Online Access:https://doi.org/10.1186/s40478-025-01979-0
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