Prostate Cancer: Epigenetic Alterations, Risk Factors, and Therapy
Prostate cancer (PCa) is the most prevalent urological cancer that affects aging men in South Africa, and mechanisms underlying prostate tumorigenesis remain elusive. Research advancements in the field of PCa and epigenetics have allowed for the identification of specific alterations that occur beyo...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Prostate Cancer |
| Online Access: | http://dx.doi.org/10.1155/2016/5653862 |
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| author | Mankgopo M. Kgatle Asgar A. Kalla Muhammed M. Islam Mike Sathekge Razia Moorad |
| author_facet | Mankgopo M. Kgatle Asgar A. Kalla Muhammed M. Islam Mike Sathekge Razia Moorad |
| author_sort | Mankgopo M. Kgatle |
| collection | DOAJ |
| description | Prostate cancer (PCa) is the most prevalent urological cancer that affects aging men in South Africa, and mechanisms underlying prostate tumorigenesis remain elusive. Research advancements in the field of PCa and epigenetics have allowed for the identification of specific alterations that occur beyond genetics but are still critically important in the pathogenesis of tumorigenesis. Anomalous epigenetic changes associated with PCa include histone modifications, DNA methylation, and noncoding miRNA. These mechanisms regulate and silence hundreds of target genes including some which are key components of cellular signalling pathways that, when perturbed, promote tumorigenesis. Elucidation of mechanisms underlying epigenetic alterations and the manner in which these mechanisms interact in regulating gene transcription in PCa are an unmet necessity that may lead to novel chemotherapeutic approaches. This will, therefore, aid in developing combination therapies that will target multiple epigenetic pathways, which can be used in conjunction with the current conventional PCa treatment. |
| format | Article |
| id | doaj-art-c9bd5e04e1134cd7a0bd2b396b3542d1 |
| institution | DOAJ |
| issn | 2090-3111 2090-312X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Prostate Cancer |
| spelling | doaj-art-c9bd5e04e1134cd7a0bd2b396b3542d12025-08-20T03:05:18ZengWileyProstate Cancer2090-31112090-312X2016-01-01201610.1155/2016/56538625653862Prostate Cancer: Epigenetic Alterations, Risk Factors, and TherapyMankgopo M. Kgatle0Asgar A. Kalla1Muhammed M. Islam2Mike Sathekge3Razia Moorad4Division of Hepatology and Liver Research, Department of Medicine, Faculty of Health Sciences, University of Cape Town and Groote Schuur Hospital, Observatory, Western Cape 7925, South AfricaDivision of Rheumatology, Department of Medicine, Faculty of Health Sciences, University of Cape Town and Groote Schuur Hospital, Observatory, Western Cape 7925, South AfricaDepartment of Integrative Biomedical Sciences, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Observatory, Western Cape 7925, South AfricaDepartment of Nuclear Medicine, University of Pretoria and Steve Biko Academic Hospital, Private Bag X169, Pretoria, Gauteng 0001, South AfricaDepartment of Surgery, Faculty of Health Science, University of Cape Town and Groote Schuur Hospital, Observatory, Western Cape 7925, South AfricaProstate cancer (PCa) is the most prevalent urological cancer that affects aging men in South Africa, and mechanisms underlying prostate tumorigenesis remain elusive. Research advancements in the field of PCa and epigenetics have allowed for the identification of specific alterations that occur beyond genetics but are still critically important in the pathogenesis of tumorigenesis. Anomalous epigenetic changes associated with PCa include histone modifications, DNA methylation, and noncoding miRNA. These mechanisms regulate and silence hundreds of target genes including some which are key components of cellular signalling pathways that, when perturbed, promote tumorigenesis. Elucidation of mechanisms underlying epigenetic alterations and the manner in which these mechanisms interact in regulating gene transcription in PCa are an unmet necessity that may lead to novel chemotherapeutic approaches. This will, therefore, aid in developing combination therapies that will target multiple epigenetic pathways, which can be used in conjunction with the current conventional PCa treatment.http://dx.doi.org/10.1155/2016/5653862 |
| spellingShingle | Mankgopo M. Kgatle Asgar A. Kalla Muhammed M. Islam Mike Sathekge Razia Moorad Prostate Cancer: Epigenetic Alterations, Risk Factors, and Therapy Prostate Cancer |
| title | Prostate Cancer: Epigenetic Alterations, Risk Factors, and Therapy |
| title_full | Prostate Cancer: Epigenetic Alterations, Risk Factors, and Therapy |
| title_fullStr | Prostate Cancer: Epigenetic Alterations, Risk Factors, and Therapy |
| title_full_unstemmed | Prostate Cancer: Epigenetic Alterations, Risk Factors, and Therapy |
| title_short | Prostate Cancer: Epigenetic Alterations, Risk Factors, and Therapy |
| title_sort | prostate cancer epigenetic alterations risk factors and therapy |
| url | http://dx.doi.org/10.1155/2016/5653862 |
| work_keys_str_mv | AT mankgopomkgatle prostatecancerepigeneticalterationsriskfactorsandtherapy AT asgarakalla prostatecancerepigeneticalterationsriskfactorsandtherapy AT muhammedmislam prostatecancerepigeneticalterationsriskfactorsandtherapy AT mikesathekge prostatecancerepigeneticalterationsriskfactorsandtherapy AT raziamoorad prostatecancerepigeneticalterationsriskfactorsandtherapy |