Antigen specificity shapes distinct aging trajectories of memory CD8⁺ T cells

Antigen specificity shapes distinct aging trajectories of memory CD8⁺ T cells

Abstract Memory T cells are a highly heterogeneous collection of antigen-experienced cells that undergo dynamic adaptations upon antigen re-encounter and environmental signals. This heterogeneity hinders studies on memory T cell durability and age-related dysfunction. Using chronic Epstein-Barr viru...

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Bibliographic Details
Main Authors: Ines Sturmlechner, Abhinav Jain, Bin Hu, Rohit R. Jadhav, Wenqiang Cao, Hirohisa Okuyama, Lu Tian, Cornelia M. Weyand, Jörg J. Goronzy
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61627-y
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