Distribution, lipophilicity and tissue half-life as key factors in sulphonamide clearance from porcine tissues
Sulphonamides are some of the most widely used antimicrobial drugs in the treatment of bacterial diseases in pigs. The study was conducted to compare the total exposure of tissue to a group of active substances in a single formulation and evaluate the impact of the volume of distribution, lipophilic...
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| Format: | Article |
| Language: | English |
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Sciendo
2025-01-01
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| Series: | Journal of Veterinary Research |
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| Online Access: | https://doi.org/10.2478/jvetres-2025-0002 |
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| author | Burmańczuk Artur Osypiuk Monika Polska Bożena Kunicki Dominik Kocik Marcin Grzęda Karol Markiewicz Włodzimierz Yilmaz Oktay Grabowski Tomasz |
| author_facet | Burmańczuk Artur Osypiuk Monika Polska Bożena Kunicki Dominik Kocik Marcin Grzęda Karol Markiewicz Włodzimierz Yilmaz Oktay Grabowski Tomasz |
| author_sort | Burmańczuk Artur |
| collection | DOAJ |
| description | Sulphonamides are some of the most widely used antimicrobial drugs in the treatment of bacterial diseases in pigs. The study was conducted to compare the total exposure of tissue to a group of active substances in a single formulation and evaluate the impact of the volume of distribution, lipophilicity and tissue half-life of sulfadimethoxine, sulphathiazole, sulphamethazine and sulphacetamide in two different veterinary drug formulations – Polisulfalent, which was preparation A, and Polisulfamid, which was preparation B. |
| format | Article |
| id | doaj-art-c9b434bcefec404ca8bc5a1f7d74ee59 |
| institution | DOAJ |
| issn | 2450-8608 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Journal of Veterinary Research |
| spelling | doaj-art-c9b434bcefec404ca8bc5a1f7d74ee592025-08-20T03:10:04ZengSciendoJournal of Veterinary Research2450-86082025-01-0169110110910.2478/jvetres-2025-0002Distribution, lipophilicity and tissue half-life as key factors in sulphonamide clearance from porcine tissuesBurmańczuk Artur0Osypiuk Monika1Polska Bożena2Kunicki Dominik3Kocik Marcin4Grzęda Karol5Markiewicz Włodzimierz6Yilmaz Oktay7Grabowski Tomasz8Department of Pharmacology, Toxicology and Environmental Protection, University of Life Sciences in Lublin, 20-033Lublin, PolandDepartment of Pharmacology, Toxicology and Environmental Protection, University of Life Sciences in Lublin, 20-033Lublin, PolandDepartment of Pharmacology, Toxicology and Environmental Protection, University of Life Sciences in Lublin, 20-033Lublin, PolandDepartment of Pharmacology, Toxicology and Environmental Protection, University of Life Sciences in Lublin, 20-033Lublin, PolandPrivate veterinary practice, 33-100Tarnów, PolandPrivate veterinary practice, 24-100Puławy, PolandDepartment of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Warmia and Mazury, 10-718Olsztyn, PolandDepartment of Obstetrics and Gynaecology, Faculty of Veterinary Medicine, Afyon Kocatepe University, ANS Campus, 03200Afyonkarahisar, TürkiyeDepartment of Inorganic Chemistry, Medical University of Gdańsk, 80-416Gdańsk, PolandSulphonamides are some of the most widely used antimicrobial drugs in the treatment of bacterial diseases in pigs. The study was conducted to compare the total exposure of tissue to a group of active substances in a single formulation and evaluate the impact of the volume of distribution, lipophilicity and tissue half-life of sulfadimethoxine, sulphathiazole, sulphamethazine and sulphacetamide in two different veterinary drug formulations – Polisulfalent, which was preparation A, and Polisulfamid, which was preparation B.https://doi.org/10.2478/jvetres-2025-0002sulphonamidespigslipophilicityvdresidues |
| spellingShingle | Burmańczuk Artur Osypiuk Monika Polska Bożena Kunicki Dominik Kocik Marcin Grzęda Karol Markiewicz Włodzimierz Yilmaz Oktay Grabowski Tomasz Distribution, lipophilicity and tissue half-life as key factors in sulphonamide clearance from porcine tissues Journal of Veterinary Research sulphonamides pigs lipophilicity vd residues |
| title | Distribution, lipophilicity and tissue half-life as key factors in sulphonamide clearance from porcine tissues |
| title_full | Distribution, lipophilicity and tissue half-life as key factors in sulphonamide clearance from porcine tissues |
| title_fullStr | Distribution, lipophilicity and tissue half-life as key factors in sulphonamide clearance from porcine tissues |
| title_full_unstemmed | Distribution, lipophilicity and tissue half-life as key factors in sulphonamide clearance from porcine tissues |
| title_short | Distribution, lipophilicity and tissue half-life as key factors in sulphonamide clearance from porcine tissues |
| title_sort | distribution lipophilicity and tissue half life as key factors in sulphonamide clearance from porcine tissues |
| topic | sulphonamides pigs lipophilicity vd residues |
| url | https://doi.org/10.2478/jvetres-2025-0002 |
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