Role of M2 macrophage-derived exosomes in cancer drug resistance via noncoding RNAs
Abstract This review summarizes recent findings on the role of M2 tumor-associated macrophages (TAMs) and their exosome-derived non-coding RNAs (ncRNAs) in cancer cell resistance to therapeutics. M2 TAMs promote angiogenesis, suppress immune responses, and facilitate metastasis, thereby creating a t...
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| Format: | Article |
| Language: | English |
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Springer
2025-05-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-025-02195-x |
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| author | Xiaopeng Hu Yanhua Li Xisheng Wang Xingkui Xue |
| author_facet | Xiaopeng Hu Yanhua Li Xisheng Wang Xingkui Xue |
| author_sort | Xiaopeng Hu |
| collection | DOAJ |
| description | Abstract This review summarizes recent findings on the role of M2 tumor-associated macrophages (TAMs) and their exosome-derived non-coding RNAs (ncRNAs) in cancer cell resistance to therapeutics. M2 TAMs promote angiogenesis, suppress immune responses, and facilitate metastasis, thereby creating a tumor-supporting microenvironment. A range of antitumor drugs, including 5-FU, cisplatin, and gemcitabine, are mediated by M2 exosomes, each with distinct mechanisms of action. M2 exosomes transfer drug resistance capabilities via extracellular vesicles, especially exosomes containing miRNAs, lncRNAs, and circRNAs. These exosome mediate the development of tumor drug resistance by regulating signaling pathways such as PI3K/AKT, MAPK/ERK, Wnt/β-catenin M2 exosomes can regulate cellular responses by delivering bioactive molecules, including proteins, lipids, and ncRNA, which can also modulate cellular reactions to ionizing radiation, ultraviolet light, and chemotherapeutic agents. Targeting M2 TAMs and their exosome-mediated ncRNAs may offer new strategies to overcome drug resistance in cancer. |
| format | Article |
| id | doaj-art-c9b2bbc13c85480a9554448e2d4b5ca0 |
| institution | OA Journals |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-c9b2bbc13c85480a9554448e2d4b5ca02025-08-20T01:51:36ZengSpringerDiscover Oncology2730-60112025-05-0116112110.1007/s12672-025-02195-xRole of M2 macrophage-derived exosomes in cancer drug resistance via noncoding RNAsXiaopeng Hu0Yanhua Li1Xisheng Wang2Xingkui Xue3Medical Research Center, People’s Hospital of LonghuaDepartment of Pathology, Shenzhen Longhua Maternity and Child Healthcare HospitalMedical Research Center, People’s Hospital of LonghuaMedical Research Center, People’s Hospital of LonghuaAbstract This review summarizes recent findings on the role of M2 tumor-associated macrophages (TAMs) and their exosome-derived non-coding RNAs (ncRNAs) in cancer cell resistance to therapeutics. M2 TAMs promote angiogenesis, suppress immune responses, and facilitate metastasis, thereby creating a tumor-supporting microenvironment. A range of antitumor drugs, including 5-FU, cisplatin, and gemcitabine, are mediated by M2 exosomes, each with distinct mechanisms of action. M2 exosomes transfer drug resistance capabilities via extracellular vesicles, especially exosomes containing miRNAs, lncRNAs, and circRNAs. These exosome mediate the development of tumor drug resistance by regulating signaling pathways such as PI3K/AKT, MAPK/ERK, Wnt/β-catenin M2 exosomes can regulate cellular responses by delivering bioactive molecules, including proteins, lipids, and ncRNA, which can also modulate cellular reactions to ionizing radiation, ultraviolet light, and chemotherapeutic agents. Targeting M2 TAMs and their exosome-mediated ncRNAs may offer new strategies to overcome drug resistance in cancer.https://doi.org/10.1007/s12672-025-02195-xM2 MacrophagesExosomesCancer TherapeuticsDrug resistancencRNAs |
| spellingShingle | Xiaopeng Hu Yanhua Li Xisheng Wang Xingkui Xue Role of M2 macrophage-derived exosomes in cancer drug resistance via noncoding RNAs Discover Oncology M2 Macrophages Exosomes Cancer Therapeutics Drug resistance ncRNAs |
| title | Role of M2 macrophage-derived exosomes in cancer drug resistance via noncoding RNAs |
| title_full | Role of M2 macrophage-derived exosomes in cancer drug resistance via noncoding RNAs |
| title_fullStr | Role of M2 macrophage-derived exosomes in cancer drug resistance via noncoding RNAs |
| title_full_unstemmed | Role of M2 macrophage-derived exosomes in cancer drug resistance via noncoding RNAs |
| title_short | Role of M2 macrophage-derived exosomes in cancer drug resistance via noncoding RNAs |
| title_sort | role of m2 macrophage derived exosomes in cancer drug resistance via noncoding rnas |
| topic | M2 Macrophages Exosomes Cancer Therapeutics Drug resistance ncRNAs |
| url | https://doi.org/10.1007/s12672-025-02195-x |
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