Vaccination burnout impedes the compliance with multiple-dose administration of vaccines
Abstract Timely and complete administration of multiple-dose vaccines is essential to guarantee the efficacy. Our study aimed to investigate how people’s vaccination attitudes changed over the course of the multi-dose vaccination schedule and comprehensively reported a phenomenon of vaccination burn...
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Nature Portfolio
2025-04-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-97959-4 |
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| author | Xueying Fan Yangguo Zhao Xinyu Zhang Shunran Li Fan Wu Mingting Cui Ying Ye Wangmu Duoji Shiqiang Jiang Jianhui Yuan Caijun Sun |
| author_facet | Xueying Fan Yangguo Zhao Xinyu Zhang Shunran Li Fan Wu Mingting Cui Ying Ye Wangmu Duoji Shiqiang Jiang Jianhui Yuan Caijun Sun |
| author_sort | Xueying Fan |
| collection | DOAJ |
| description | Abstract Timely and complete administration of multiple-dose vaccines is essential to guarantee the efficacy. Our study aimed to investigate how people’s vaccination attitudes changed over the course of the multi-dose vaccination schedule and comprehensively reported a phenomenon of vaccination burnout. The participants’ vaccination burnout levels were quantified by our designed vaccination burnout scale. This study is a retrospective cross-sectional study. Among 3068 valid participants, 2991 had finished the routine two shots of COVID-19 vaccine, and 2367 had a positive attitude towards the primary doses of vaccination. Notably, 232 participants who previously had a positive attitude towards primary doses of vaccination refused to take additional multiple shots, and another 83 had changed their positive attitudes to negative, despite having taken the third shot. Participants whose attitudes or behaviors had changed had higher scores of vaccination burnout than those who still maintained a positive attitude (Z=−8.491, P < .001). The frequency of actively paying attention to the related disease news, occupation, monthly income, and residence of the participants were key factors associated with the vaccination burnout. Interventions should be implemented to alleviate the exhausted attitudes and improve people’s compliance with vaccination schedules against the future pandemic. |
| format | Article |
| id | doaj-art-c9aa2a013b864d23a27f0ac665be93b5 |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-c9aa2a013b864d23a27f0ac665be93b52025-08-20T03:18:30ZengNature PortfolioScientific Reports2045-23222025-04-0115111110.1038/s41598-025-97959-4Vaccination burnout impedes the compliance with multiple-dose administration of vaccinesXueying Fan0Yangguo Zhao1Xinyu Zhang2Shunran Li3Fan Wu4Mingting Cui5Ying Ye6Wangmu Duoji7Shiqiang Jiang8Jianhui Yuan9Caijun Sun10Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, Shenzhen Campus of Sun Yat-sen UniversityShenzhen Key Laboratory of Pathogenic Microbes and Biosafety, Shenzhen Campus of Sun Yat-sen UniversityShenzhen Key Laboratory of Pathogenic Microbes and Biosafety, Shenzhen Campus of Sun Yat-sen UniversityShenzhen Key Laboratory of Pathogenic Microbes and Biosafety, Shenzhen Campus of Sun Yat-sen UniversityShenzhen Key Laboratory of Pathogenic Microbes and Biosafety, Shenzhen Campus of Sun Yat-sen UniversityShenzhen Key Laboratory of Pathogenic Microbes and Biosafety, Shenzhen Campus of Sun Yat-sen UniversityShenzhen Key Laboratory of Pathogenic Microbes and Biosafety, Shenzhen Campus of Sun Yat-sen UniversityTibet Center for Disease Control and PreventionNanshan District Center for Disease Control and PreventionNanshan District Center for Disease Control and PreventionShenzhen Key Laboratory of Pathogenic Microbes and Biosafety, Shenzhen Campus of Sun Yat-sen UniversityAbstract Timely and complete administration of multiple-dose vaccines is essential to guarantee the efficacy. Our study aimed to investigate how people’s vaccination attitudes changed over the course of the multi-dose vaccination schedule and comprehensively reported a phenomenon of vaccination burnout. The participants’ vaccination burnout levels were quantified by our designed vaccination burnout scale. This study is a retrospective cross-sectional study. Among 3068 valid participants, 2991 had finished the routine two shots of COVID-19 vaccine, and 2367 had a positive attitude towards the primary doses of vaccination. Notably, 232 participants who previously had a positive attitude towards primary doses of vaccination refused to take additional multiple shots, and another 83 had changed their positive attitudes to negative, despite having taken the third shot. Participants whose attitudes or behaviors had changed had higher scores of vaccination burnout than those who still maintained a positive attitude (Z=−8.491, P < .001). The frequency of actively paying attention to the related disease news, occupation, monthly income, and residence of the participants were key factors associated with the vaccination burnout. Interventions should be implemented to alleviate the exhausted attitudes and improve people’s compliance with vaccination schedules against the future pandemic.https://doi.org/10.1038/s41598-025-97959-4Vaccination burnoutCOVID-19 vaccinePublic healthMultiple-dose vaccinationCase study |
| spellingShingle | Xueying Fan Yangguo Zhao Xinyu Zhang Shunran Li Fan Wu Mingting Cui Ying Ye Wangmu Duoji Shiqiang Jiang Jianhui Yuan Caijun Sun Vaccination burnout impedes the compliance with multiple-dose administration of vaccines Scientific Reports Vaccination burnout COVID-19 vaccine Public health Multiple-dose vaccination Case study |
| title | Vaccination burnout impedes the compliance with multiple-dose administration of vaccines |
| title_full | Vaccination burnout impedes the compliance with multiple-dose administration of vaccines |
| title_fullStr | Vaccination burnout impedes the compliance with multiple-dose administration of vaccines |
| title_full_unstemmed | Vaccination burnout impedes the compliance with multiple-dose administration of vaccines |
| title_short | Vaccination burnout impedes the compliance with multiple-dose administration of vaccines |
| title_sort | vaccination burnout impedes the compliance with multiple dose administration of vaccines |
| topic | Vaccination burnout COVID-19 vaccine Public health Multiple-dose vaccination Case study |
| url | https://doi.org/10.1038/s41598-025-97959-4 |
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