Characteristics of the initial dengue outbreaks in a region without dengue prior to mid-2009 in a dengue-endemic country
Introduction: The present study evaluated the characteristics of the initial dengue outbreaks in the Jaffna peninsula, a region without dengue prior to mid-2009 in dengue-endemic Sri Lanka, a tropical island nation. Methodology: This is a cross-sectional study conducted using a total of 765 dengu...
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The Journal of Infection in Developing Countries
2023-02-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/15493 |
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| author | Kalamathy Murugananthan Dinesh Coonghe Thirunawukarasu Kumanan Arumugam Murugananthan Gowri Selvaratnam Sivapalan Sivansuthan Gitanjali Sathiadas Natkunam Ketheesan Faizal A Careem Faseeha Noordeen |
| author_facet | Kalamathy Murugananthan Dinesh Coonghe Thirunawukarasu Kumanan Arumugam Murugananthan Gowri Selvaratnam Sivapalan Sivansuthan Gitanjali Sathiadas Natkunam Ketheesan Faizal A Careem Faseeha Noordeen |
| author_sort | Kalamathy Murugananthan |
| collection | DOAJ |
| description |
Introduction: The present study evaluated the characteristics of the initial dengue outbreaks in the Jaffna peninsula, a region without dengue prior to mid-2009 in dengue-endemic Sri Lanka, a tropical island nation.
Methodology: This is a cross-sectional study conducted using a total of 765 dengue patients’ clinical data and samples collected from the Teaching Hospital, Jaffna during the initial dengue outbreaks. Clinical, non-specific, and specific virological laboratory characteristics including the platelet count, NS1 antigen, and anti-DENV IgM/IgG were evaluated as correlates of dengue virus (DENV) infection in the two initial outbreaks of 2009/2010 and 2011/2012 in Northern Sri Lanka.
Results: Firstly, affected age and clinical characteristics were significantly different between the outbreaks (p < 0.005). Secondly, NS1 antigen detection in patients with fever days < 5 was statistically significant (p < 0.005). Thirdly, platelet count, detection of NS1 antigen, and anti-DENV IgM/IgG profiles were adequate to diagnose 90% of the patients; hepatomegaly and platelet count of < 25,000/mm3 were identified as predictors of severe disease. Fourthly, secondary DENV infections were detected in the early stages of the illness in many patients. Finally, infecting DENV serotypes were different between the two outbreaks.
Conclusions: Clinical and non-specific laboratory characteristics and the infecting DENV serotypes between the two initial outbreaks in Northern Sri Lanka were significantly different. NS1 antigen, anti-DENV IgM/IgG, and platelet counts were identified 90% of the dengue patients. Hepatomegaly and platelet count of < 25,000/mm3 were able to predict the disease severity in this study.
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| format | Article |
| id | doaj-art-c9928cdd518a4e4db0da968e91be7bfe |
| institution | Kabale University |
| issn | 1972-2680 |
| language | English |
| publishDate | 2023-02-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-c9928cdd518a4e4db0da968e91be7bfe2025-08-20T03:52:42ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802023-02-01170210.3855/jidc.15493Characteristics of the initial dengue outbreaks in a region without dengue prior to mid-2009 in a dengue-endemic countryKalamathy Murugananthan0Dinesh Coonghe1Thirunawukarasu Kumanan2Arumugam Murugananthan3Gowri Selvaratnam4Sivapalan Sivansuthan5Gitanjali Sathiadas6Natkunam Ketheesan7Faizal A Careem8Faseeha Noordeen9Department of Microbiology, Faculty of Medicine, University of Jaffna, Jaffna, Sri LankaDepartment of Community and Family Medicine, Faculty of Medicine, University of Jaffna, Jaffna, Sri LankaDepartment of Medicine, Faculty of Medicine, University of Jaffna, Jaffna, Sri Lanka Department of Parasitology, Faculty of Medicine, University of Jaffna, Jaffna, Sri LankaDepartment of Medicine, Faculty of Medicine, University of Jaffna, Jaffna, Sri Lanka Teaching Hospital, Jaffna, Sri LankaDepartment of Paediatrics, Faculty of Medicine, University of Jaffna, Jaffna, Sri LankaScience and Technology, University of New England, Armadale, AustraliaDepartment of Ecosystem and Public Health, University of Calgary, Alberta, CanadaDiagnostic and Research Virology Laboratory, Department of Microbiology, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka Introduction: The present study evaluated the characteristics of the initial dengue outbreaks in the Jaffna peninsula, a region without dengue prior to mid-2009 in dengue-endemic Sri Lanka, a tropical island nation. Methodology: This is a cross-sectional study conducted using a total of 765 dengue patients’ clinical data and samples collected from the Teaching Hospital, Jaffna during the initial dengue outbreaks. Clinical, non-specific, and specific virological laboratory characteristics including the platelet count, NS1 antigen, and anti-DENV IgM/IgG were evaluated as correlates of dengue virus (DENV) infection in the two initial outbreaks of 2009/2010 and 2011/2012 in Northern Sri Lanka. Results: Firstly, affected age and clinical characteristics were significantly different between the outbreaks (p < 0.005). Secondly, NS1 antigen detection in patients with fever days < 5 was statistically significant (p < 0.005). Thirdly, platelet count, detection of NS1 antigen, and anti-DENV IgM/IgG profiles were adequate to diagnose 90% of the patients; hepatomegaly and platelet count of < 25,000/mm3 were identified as predictors of severe disease. Fourthly, secondary DENV infections were detected in the early stages of the illness in many patients. Finally, infecting DENV serotypes were different between the two outbreaks. Conclusions: Clinical and non-specific laboratory characteristics and the infecting DENV serotypes between the two initial outbreaks in Northern Sri Lanka were significantly different. NS1 antigen, anti-DENV IgM/IgG, and platelet counts were identified 90% of the dengue patients. Hepatomegaly and platelet count of < 25,000/mm3 were able to predict the disease severity in this study. https://jidc.org/index.php/journal/article/view/15493Dengueinitial outbreaksclinicallaboratoryvirological characteristics |
| spellingShingle | Kalamathy Murugananthan Dinesh Coonghe Thirunawukarasu Kumanan Arumugam Murugananthan Gowri Selvaratnam Sivapalan Sivansuthan Gitanjali Sathiadas Natkunam Ketheesan Faizal A Careem Faseeha Noordeen Characteristics of the initial dengue outbreaks in a region without dengue prior to mid-2009 in a dengue-endemic country Journal of Infection in Developing Countries Dengue initial outbreaks clinical laboratory virological characteristics |
| title | Characteristics of the initial dengue outbreaks in a region without dengue prior to mid-2009 in a dengue-endemic country |
| title_full | Characteristics of the initial dengue outbreaks in a region without dengue prior to mid-2009 in a dengue-endemic country |
| title_fullStr | Characteristics of the initial dengue outbreaks in a region without dengue prior to mid-2009 in a dengue-endemic country |
| title_full_unstemmed | Characteristics of the initial dengue outbreaks in a region without dengue prior to mid-2009 in a dengue-endemic country |
| title_short | Characteristics of the initial dengue outbreaks in a region without dengue prior to mid-2009 in a dengue-endemic country |
| title_sort | characteristics of the initial dengue outbreaks in a region without dengue prior to mid 2009 in a dengue endemic country |
| topic | Dengue initial outbreaks clinical laboratory virological characteristics |
| url | https://jidc.org/index.php/journal/article/view/15493 |
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