Case Report: ALK-rearranged mesenchymal neoplasms with S100 and CD34 co-expression: additional cases with distinct characteristics
ALK rearrangements are rarely documented in superficial soft tissue neoplasms exhibiting an infantile fibrosarcoma-like spindle cell tumor (IFS) pattern or stromal, resembling Neurotrophic Tyrosine Kinase Receptor(NTRK)rearranged spindle cell tumors. Here, we present two cases of pediatric cutaneous...
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1516491/full |
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| author | Qi Ouyang Xiaohong Guo Rongjun Mao Zhixing Cao |
| author_facet | Qi Ouyang Xiaohong Guo Rongjun Mao Zhixing Cao |
| author_sort | Qi Ouyang |
| collection | DOAJ |
| description | ALK rearrangements are rarely documented in superficial soft tissue neoplasms exhibiting an infantile fibrosarcoma-like spindle cell tumor (IFS) pattern or stromal, resembling Neurotrophic Tyrosine Kinase Receptor(NTRK)rearranged spindle cell tumors. Here, we present two cases of pediatric cutaneous soft tissue tumors with an IFS pattern, in which ALK fusions involving related partner genes were identified. The tumors in both cases demonstrated similar morphology and consisted of ovoid and spindle cells with infiltrative boundaries. The spindle cells exhibited either a fascicular growth pattern or a haphazard pattern and stromal hyalinization. Both cases involved inflammatory cell infiltration, brisk mitosis, and CD34, S100, and ALK-D5F3 immunoreactivity. Next-generation sequencing identified ALK fusion with different partner genes (STRN and PLEKHH2). The fluorescence in situ hybridization break-apart assay confirmed ALK rearrangements in both cases. In case 1, no indications of disease progression or metastasis was observed within the limited follow-up (36 months). However, the patient in case 2 experienced a rapid recurrence and metastasis. |
| format | Article |
| id | doaj-art-c98ccb46ac2b4e8198dbf78a1fb60a1c |
| institution | DOAJ |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-c98ccb46ac2b4e8198dbf78a1fb60a1c2025-08-20T03:22:18ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-05-011510.3389/fonc.2025.15164911516491Case Report: ALK-rearranged mesenchymal neoplasms with S100 and CD34 co-expression: additional cases with distinct characteristicsQi Ouyang0Xiaohong Guo1Rongjun Mao2Zhixing Cao3Department of Pathology, Zhuhai People’s Hospital (Zhuhai Clinical Medical College of Jinan University), Zhuhai, Guangdong, ChinaDepartment of Pathology, Zhuhai People’s Hospital (Zhuhai Clinical Medical College of Jinan University), Zhuhai, Guangdong, ChinaDepartment of Pathology, Foshan Hospital of Traditional Chinese Medicine, Foshan, Guangdong, ChinaDepartment of Pathology, Zhuhai People’s Hospital (Zhuhai Clinical Medical College of Jinan University), Zhuhai, Guangdong, ChinaALK rearrangements are rarely documented in superficial soft tissue neoplasms exhibiting an infantile fibrosarcoma-like spindle cell tumor (IFS) pattern or stromal, resembling Neurotrophic Tyrosine Kinase Receptor(NTRK)rearranged spindle cell tumors. Here, we present two cases of pediatric cutaneous soft tissue tumors with an IFS pattern, in which ALK fusions involving related partner genes were identified. The tumors in both cases demonstrated similar morphology and consisted of ovoid and spindle cells with infiltrative boundaries. The spindle cells exhibited either a fascicular growth pattern or a haphazard pattern and stromal hyalinization. Both cases involved inflammatory cell infiltration, brisk mitosis, and CD34, S100, and ALK-D5F3 immunoreactivity. Next-generation sequencing identified ALK fusion with different partner genes (STRN and PLEKHH2). The fluorescence in situ hybridization break-apart assay confirmed ALK rearrangements in both cases. In case 1, no indications of disease progression or metastasis was observed within the limited follow-up (36 months). However, the patient in case 2 experienced a rapid recurrence and metastasis.https://www.frontiersin.org/articles/10.3389/fonc.2025.1516491/fullcase reportcutaneousspindle tumorinfantile fibrosarcoma-like tumorALK rearrangement |
| spellingShingle | Qi Ouyang Xiaohong Guo Rongjun Mao Zhixing Cao Case Report: ALK-rearranged mesenchymal neoplasms with S100 and CD34 co-expression: additional cases with distinct characteristics Frontiers in Oncology case report cutaneous spindle tumor infantile fibrosarcoma-like tumor ALK rearrangement |
| title | Case Report: ALK-rearranged mesenchymal neoplasms with S100 and CD34 co-expression: additional cases with distinct characteristics |
| title_full | Case Report: ALK-rearranged mesenchymal neoplasms with S100 and CD34 co-expression: additional cases with distinct characteristics |
| title_fullStr | Case Report: ALK-rearranged mesenchymal neoplasms with S100 and CD34 co-expression: additional cases with distinct characteristics |
| title_full_unstemmed | Case Report: ALK-rearranged mesenchymal neoplasms with S100 and CD34 co-expression: additional cases with distinct characteristics |
| title_short | Case Report: ALK-rearranged mesenchymal neoplasms with S100 and CD34 co-expression: additional cases with distinct characteristics |
| title_sort | case report alk rearranged mesenchymal neoplasms with s100 and cd34 co expression additional cases with distinct characteristics |
| topic | case report cutaneous spindle tumor infantile fibrosarcoma-like tumor ALK rearrangement |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1516491/full |
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