Role of TGF-β1/SMAD signaling cascade in the regulation of cyclooxygenase-2 expression in human breast cancer cells
The expression of the SMAD2, SMAD4, SMAD7, and СOX-2 genes and the levels of Smad4, phosphorylated Smad2, and Smad7 proteins were analyzed in the human breast cancer (BC) cell lines MCF-7, BT-474, and ZR-75-1. The SMAD2 and SMAD4 genes were found to suppress COX-2 gene expression in the estrogen rec...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2014-07-01
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| Series: | Опухоли женской репродуктивной системы |
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| Online Access: | https://ojrs.abvpress.ru/ojrs/article/view/33 |
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| author | M. A. Taipov Z. N. Nikiforova O. M. Pavlova I. A. Kudryavtsev N. Ye. Arnotskaya V. Ye. Shevchenko |
| author_facet | M. A. Taipov Z. N. Nikiforova O. M. Pavlova I. A. Kudryavtsev N. Ye. Arnotskaya V. Ye. Shevchenko |
| author_sort | M. A. Taipov |
| collection | DOAJ |
| description | The expression of the SMAD2, SMAD4, SMAD7, and СOX-2 genes and the levels of Smad4, phosphorylated Smad2, and Smad7 proteins were analyzed in the human breast cancer (BC) cell lines MCF-7, BT-474, and ZR-75-1. The SMAD2 and SMAD4 genes were found to suppress COX-2 gene expression in the estrogen receptor-positive BC cells and to be linked to their metastatic potential. Smad4 and Smad2 apparently suppress COX-2 mRNA and protein synthesis and Smad7 is their antagonist and stimulates COX-2 formation. Smad2, Smad4, Smad7 proteins may be regarded as new potential targets for targeted BC therapy. |
| format | Article |
| id | doaj-art-c98ca73b0720479eb0a96d9ba11d1b63 |
| institution | Kabale University |
| issn | 1994-4098 1999-8627 |
| language | Russian |
| publishDate | 2014-07-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли женской репродуктивной системы |
| spelling | doaj-art-c98ca73b0720479eb0a96d9ba11d1b632025-08-20T04:00:02ZrusABV-pressОпухоли женской репродуктивной системы1994-40981999-86272014-07-0101-261210.17650/1994-4098-2013-0-1-2-6-1248Role of TGF-β1/SMAD signaling cascade in the regulation of cyclooxygenase-2 expression in human breast cancer cellsM. A. Taipov0Z. N. Nikiforova1O. M. Pavlova2I. A. Kudryavtsev3N. Ye. Arnotskaya4V. Ye. Shevchenko5N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowN.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowN.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowN.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowN.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowN.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowThe expression of the SMAD2, SMAD4, SMAD7, and СOX-2 genes and the levels of Smad4, phosphorylated Smad2, and Smad7 proteins were analyzed in the human breast cancer (BC) cell lines MCF-7, BT-474, and ZR-75-1. The SMAD2 and SMAD4 genes were found to suppress COX-2 gene expression in the estrogen receptor-positive BC cells and to be linked to their metastatic potential. Smad4 and Smad2 apparently suppress COX-2 mRNA and protein synthesis and Smad7 is their antagonist and stimulates COX-2 formation. Smad2, Smad4, Smad7 proteins may be regarded as new potential targets for targeted BC therapy.https://ojrs.abvpress.ru/ojrs/article/view/33breast cancercyclooxygenase-2 (cox-2)tgf-β1/smad signaling pathwaysmad2smad4and smad7 genessmad4smad2and smad7 proteinsphosphorylated smad2inhibitors of cox-2pge2human breast cancer cell lines mcf-7bt-474and zr- 75-1targets f |
| spellingShingle | M. A. Taipov Z. N. Nikiforova O. M. Pavlova I. A. Kudryavtsev N. Ye. Arnotskaya V. Ye. Shevchenko Role of TGF-β1/SMAD signaling cascade in the regulation of cyclooxygenase-2 expression in human breast cancer cells Опухоли женской репродуктивной системы breast cancer cyclooxygenase-2 (cox-2) tgf-β1/smad signaling pathway smad2 smad4 and smad7 genes smad4 smad2 and smad7 proteins phosphorylated smad2 inhibitors of cox-2 pge2 human breast cancer cell lines mcf-7 bt-474 and zr- 75-1 targets f |
| title | Role of TGF-β1/SMAD signaling cascade in the regulation of cyclooxygenase-2 expression in human breast cancer cells |
| title_full | Role of TGF-β1/SMAD signaling cascade in the regulation of cyclooxygenase-2 expression in human breast cancer cells |
| title_fullStr | Role of TGF-β1/SMAD signaling cascade in the regulation of cyclooxygenase-2 expression in human breast cancer cells |
| title_full_unstemmed | Role of TGF-β1/SMAD signaling cascade in the regulation of cyclooxygenase-2 expression in human breast cancer cells |
| title_short | Role of TGF-β1/SMAD signaling cascade in the regulation of cyclooxygenase-2 expression in human breast cancer cells |
| title_sort | role of tgf β1 smad signaling cascade in the regulation of cyclooxygenase 2 expression in human breast cancer cells |
| topic | breast cancer cyclooxygenase-2 (cox-2) tgf-β1/smad signaling pathway smad2 smad4 and smad7 genes smad4 smad2 and smad7 proteins phosphorylated smad2 inhibitors of cox-2 pge2 human breast cancer cell lines mcf-7 bt-474 and zr- 75-1 targets f |
| url | https://ojrs.abvpress.ru/ojrs/article/view/33 |
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