Loss of hepatic autophagy induces α‐cell proliferation through impaired glutamine‐dependent gluconeogenesis

Loss of hepatic autophagy induces α‐cell proliferation through impaired glutamine‐dependent gluconeogenesis

Abstract Autophagy, the highly conserved process of protein and organelle degradation, is suppressed in the liver by obesity and metabolic dysfunction‐associated fatty liver disease and associated with the development of insulin resistance. We generated adult liver‐inducible ATG3 knockout mice (Atg3...

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Bibliographic Details
Main Authors: Jesse N. Velasco‐Silva, Joseph L. Wilkerson, Daniela Ramos, Hayden K. Low, Faith Bowman, Kimberley J. Evason, Sihem Boudina, William L. Holland, Gregory S. Ducker
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:Physiological Reports
Subjects:
alpha cell
autophagy
glucose
hyperglucagonemia
liver metabolism
Online Access:https://doi.org/10.14814/phy2.70381
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