TNF inhibitors affect the induction and maintenance of spike-specific B-cell responses after mRNA vaccination

TNF inhibitors affect the induction and maintenance of spike-specific B-cell responses after mRNA vaccination

Objectives Tumour necrosis factor inhibitors (TNFi) are widely used and effective as treatment for immune-mediated inflammatory diseases (IMIDs). However, TNFi therapy causes a faster waning of antibody responses following vaccination. The underlying cause by which TNFi affect humoral immunity remai...

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Main Authors: Sander W Tas, Taco W Kuijpers, Gertjan Wolbink, Theo Rispens, Anja Ten Brinke, Juan J Garcia-Vallejo, S Marieke van Ham, Mark Löwenberg, Luuk Wieske, Laura Boekel, Filip Eftimov, Eileen W Stalman, Maurice Steenhuis, Adriaan G Volkers, Christine Kreher, Lisan H Kuijper, Mariël C Duurland, Laura Fernández Blanco, Amélie Bos, Charlotte Menage, Tineke Jorritsma, Marit J van Gils, Mathieu Claireaux, Geert RAM D’Haens, Laura YL Kummer, Niels JM Verstegen, Veronique AL Konijn, Maryse Tempert, Koos PJ van Dam
Format: Article
Language:English
Published: BMJ Publishing Group 2025-08-01
Series:RMD Open
Online Access:https://rmdopen.bmj.com/content/11/3/e005724.full
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https://rmdopen.bmj.com/content/11/3/e005724.full

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