Machine learning suggests polygenic risk for cognitive dysfunction in amyotrophic lateral sclerosis

Abstract Amyotrophic lateral sclerosis (ALS) is a multi‐system disease characterized primarily by progressive muscle weakness. Cognitive dysfunction is commonly observed in patients; however, factors influencing risk for cognitive dysfunction remain elusive. Using sparse canonical correlation analys...

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Main Authors:	Katerina Placek, Michael Benatar, Joanne Wuu, Evadnie Rampersaud, Laura Hennessy, Vivianna M Van Deerlin, Murray Grossman, David J Irwin, Lauren Elman, Leo McCluskey, Colin Quinn, Volkan Granit, Jeffrey M Statland, Ted M Burns, John Ravits, Andrea Swenson, Jon Katz, Erik P Pioro, Carlayne Jackson, James Caress, Yuen So, Samuel Maiser, David Walk, Edward B Lee, John Q Trojanowski, Philip Cook, James Gee, Jin Sha, Adam C Naj, Rosa Rademakers, The CReATe Consortium, Wenan Chen, Gang Wu, J Paul Taylor, Corey T McMillan
Format:	Article
Language:	English
Published:	Springer Nature 2020-12-01
Series:	EMBO Molecular Medicine
Subjects:	amyotrophic lateral sclerosis cognition frontotemporal dementia machine learning polygenic score
Online Access:	https://doi.org/10.15252/emmm.202012595
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Machine learning suggests polygenic risk for cognitive dysfunction in amyotrophic lateral sclerosis

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