Prenatal Perfluorooctanoic Acid (PFOA) exposure causes reproductive toxicity by disrupting the formation of transzonal projections (TZPs) and down-regulating Wnt4/β-catenin signaling pathway in progeny

Prenatal Perfluorooctanoic Acid (PFOA) exposure causes reproductive toxicity by disrupting the formation of transzonal projections (TZPs) and down-regulating Wnt4/β-catenin signaling pathway in progeny

Perfluorooctanoic acid (PFOA) has been recognized as a novel persistent organic pollutant, playing a significant role in global environmental contamination. Recent evidence indicates that exposure to PFOA detrimentally affects reproductive function, notably through a progressive decline in ovarian f...

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Bibliographic Details
Main Authors: Hua Du, Lishuang Song, Min Zhao, Xiaorong Zhao, Ren Mu, Shengtao Gao, Bin Zhang, Jiapeng Wang
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Perfluorooctanoic acid
Transzonal projections
β-catenin
N-cadherin
Wnt4
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651325001526
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