Burden of chronic spontaneous urticaria relative to atopic dermatitis and psoriasis in the United States
Purpose To evaluate the burden of chronic spontaneous urticaria (CSU) compared with atopic dermatitis (AD) and psoriasis (PSO).Methods This retrospective, cross-sectional study used real-world data from adult respondents from the 2019 US National Health and Wellness Survey (NHWS). Outcome measures i...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Journal of Dermatological Treatment |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/09546634.2025.2517384 |
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| author | Weily Soong Dhaval Patil Jonathan Rodrigues Ravneet K. Kohli Kathryn Krupsky Shaloo Gupta Bridget L. Balkaran Maria-Magdalena Balp |
| author_facet | Weily Soong Dhaval Patil Jonathan Rodrigues Ravneet K. Kohli Kathryn Krupsky Shaloo Gupta Bridget L. Balkaran Maria-Magdalena Balp |
| author_sort | Weily Soong |
| collection | DOAJ |
| description | Purpose To evaluate the burden of chronic spontaneous urticaria (CSU) compared with atopic dermatitis (AD) and psoriasis (PSO).Methods This retrospective, cross-sectional study used real-world data from adult respondents from the 2019 US National Health and Wellness Survey (NHWS). Outcome measures included the 36-item Short-Form Survey version 2 (SF-36v2; mental and physical component summary [MCS and PCS] scores), Work Productivity and Activity Impairment (WPAI), and healthcare resource utilization (HCRU).Results Among 74,994 respondents (CSU N = 371; AD N = 549; PSO N = 2061), mean (standard deviation [SD]) age at data collection was 41.7 (14.0), 48.4 (16.3), and 51.4 (16.6) years for CSU, AD, and PSO, respectively. Mean (standard error [SE]) MCS and PCS scores were lower (worse) among respondents with physician-diagnosed CSU vs. AD and PSO, respectively: MCS: 41.3 (0.6) vs. 44.8 (0.5) vs. 45.3 (0.2); PCS: 42.1 (0.5) vs. 47.8 (0.4) vs. 47.7 (0.2); all p < 0.001. Respondents with CSU reported higher (p < 0.001) work and activity impairment and HCRU vs. respondents with AD or PSO.Conclusion After adjusting for confounders, respondents with CSU experienced higher humanistic and economic burden compared with respondents with AD or PSO, indicating a need for new treatments and improved clinical management. |
| format | Article |
| id | doaj-art-c9799ee4b72940ef92ec9109117d74e4 |
| institution | DOAJ |
| issn | 0954-6634 1471-1753 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Dermatological Treatment |
| spelling | doaj-art-c9799ee4b72940ef92ec9109117d74e42025-08-20T03:24:03ZengTaylor & Francis GroupJournal of Dermatological Treatment0954-66341471-17532025-12-0136110.1080/09546634.2025.2517384Burden of chronic spontaneous urticaria relative to atopic dermatitis and psoriasis in the United StatesWeily Soong0Dhaval Patil1Jonathan Rodrigues2Ravneet K. Kohli3Kathryn Krupsky4Shaloo Gupta5Bridget L. Balkaran6Maria-Magdalena Balp7Clinical Research Center of Alabama, AllerVie Health-Alabama Allergy & Asthma Center, Birmingham, AL, USANovartis Pharmaceuticals Corporation, East Hanover, NJ, USANovartis Pharmaceuticals Corporation, East Hanover, NJ, USANovartis Healthcare Pvt Ltd., Hyderabad, IndiaOracle Life Sciences, Austin, TX, USAOracle Life Sciences, Austin, TX, USAOracle Life Sciences, Austin, TX, USANovartis Pharma AG, Basel, SwitzerlandPurpose To evaluate the burden of chronic spontaneous urticaria (CSU) compared with atopic dermatitis (AD) and psoriasis (PSO).Methods This retrospective, cross-sectional study used real-world data from adult respondents from the 2019 US National Health and Wellness Survey (NHWS). Outcome measures included the 36-item Short-Form Survey version 2 (SF-36v2; mental and physical component summary [MCS and PCS] scores), Work Productivity and Activity Impairment (WPAI), and healthcare resource utilization (HCRU).Results Among 74,994 respondents (CSU N = 371; AD N = 549; PSO N = 2061), mean (standard deviation [SD]) age at data collection was 41.7 (14.0), 48.4 (16.3), and 51.4 (16.6) years for CSU, AD, and PSO, respectively. Mean (standard error [SE]) MCS and PCS scores were lower (worse) among respondents with physician-diagnosed CSU vs. AD and PSO, respectively: MCS: 41.3 (0.6) vs. 44.8 (0.5) vs. 45.3 (0.2); PCS: 42.1 (0.5) vs. 47.8 (0.4) vs. 47.7 (0.2); all p < 0.001. Respondents with CSU reported higher (p < 0.001) work and activity impairment and HCRU vs. respondents with AD or PSO.Conclusion After adjusting for confounders, respondents with CSU experienced higher humanistic and economic burden compared with respondents with AD or PSO, indicating a need for new treatments and improved clinical management.https://www.tandfonline.com/doi/10.1080/09546634.2025.2517384Chronic spontaneous urticariahumanistic burdeneconomic burdenwork and activity impairmenthealthcare resource utilizationUnited States |
| spellingShingle | Weily Soong Dhaval Patil Jonathan Rodrigues Ravneet K. Kohli Kathryn Krupsky Shaloo Gupta Bridget L. Balkaran Maria-Magdalena Balp Burden of chronic spontaneous urticaria relative to atopic dermatitis and psoriasis in the United States Journal of Dermatological Treatment Chronic spontaneous urticaria humanistic burden economic burden work and activity impairment healthcare resource utilization United States |
| title | Burden of chronic spontaneous urticaria relative to atopic dermatitis and psoriasis in the United States |
| title_full | Burden of chronic spontaneous urticaria relative to atopic dermatitis and psoriasis in the United States |
| title_fullStr | Burden of chronic spontaneous urticaria relative to atopic dermatitis and psoriasis in the United States |
| title_full_unstemmed | Burden of chronic spontaneous urticaria relative to atopic dermatitis and psoriasis in the United States |
| title_short | Burden of chronic spontaneous urticaria relative to atopic dermatitis and psoriasis in the United States |
| title_sort | burden of chronic spontaneous urticaria relative to atopic dermatitis and psoriasis in the united states |
| topic | Chronic spontaneous urticaria humanistic burden economic burden work and activity impairment healthcare resource utilization United States |
| url | https://www.tandfonline.com/doi/10.1080/09546634.2025.2517384 |
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