RNF20/RNF40 supports the aggressive behavior in cervical cancer by regulating a peroxisome-based anti-ferroptotic mechanism

RNF20/RNF40 supports the aggressive behavior in cervical cancer by regulating a peroxisome-based anti-ferroptotic mechanism

Abstract Background Cervical cancer is the fourth most common cancer entity in women worldwide. Currently, malignant lesions are clinically managed by surgery, conventional chemotherapy, and/or radiotherapy. However, a significant fraction of patients with cervical cancer does not respond to such tr...

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Main Authors: Shaishavi Jansari, Anna Blandau, Evangelos Prokakis, Daniela Grimm, Anja Maria Naßl, Stefan Küffer, Wiebke Möbius, Christian Dullin, Fernanda Ramos-Gomes, Leona Schüürhuis, Lena Fritsche, Laura Schridde, Matthias Plessner, Carolin. A. Bast, Fabian A. Gayer, Sven Thoms, Julia Gallwas, Florian Wegwitz
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Cell Communication and Signaling
Subjects:
Cervical cancer
RNF20/RNF40
H2Bub1
Peroxisomes
Ferroptosis
Online Access:https://doi.org/10.1186/s12964-025-02279-9
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