The Initial Months of Antiretroviral Therapy and Its Influence on AGEs, HMGB1, and sRAGE Levels in Asymptomatic HIV-Infected Individuals
The development of the typical comorbidities of aging which currently affects people living with HIV/AIDS (PLWHA) can be partially ascribed to the persistent immune activation and chronic inflammation characterizing these individuals. The aim of this study was to analyze the effect exerted by combin...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/2909576 |
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| author | Karen Ingrid Tasca Juliana Trindade Caleffi Camila Renata Correa Mariana Gatto Caio Cavassan de Camargo Monica Bannwart Mendes Marjorie de Assis Golim Mara Biasin Lenice do Rosário de Souza |
| author_facet | Karen Ingrid Tasca Juliana Trindade Caleffi Camila Renata Correa Mariana Gatto Caio Cavassan de Camargo Monica Bannwart Mendes Marjorie de Assis Golim Mara Biasin Lenice do Rosário de Souza |
| author_sort | Karen Ingrid Tasca |
| collection | DOAJ |
| description | The development of the typical comorbidities of aging which currently affects people living with HIV/AIDS (PLWHA) can be partially ascribed to the persistent immune activation and chronic inflammation characterizing these individuals. The aim of this study was to analyze the effect exerted by combined antiretroviral therapy (cART) administration on plasma levels of HMGB1 (high mobility group box protein-1), AGEs (advanced glycation end products), their soluble receptor sRAGE, cytokines, C-reactive protein (CRP), and some metabolic markers in asymptomatic PLWHA. Analyses were performed longitudinally in 30 PLWHA, before and about 6–12 months after cART initiation. We observed that lower levels of AGEs in post-cART group were accompanied by an increase of CRP and triglyceride levels already in the early months of therapy. Because of the current ever-earlier recommendations to start cART and its prolonged use, these and other markers should be investigated in order to monitor and postpone the appearance of non-AIDS comorbidities in PLWHA. |
| format | Article |
| id | doaj-art-c9758bd0f7104a668c90efc5f294a9b1 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-c9758bd0f7104a668c90efc5f294a9b12025-02-03T01:20:22ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/29095762909576The Initial Months of Antiretroviral Therapy and Its Influence on AGEs, HMGB1, and sRAGE Levels in Asymptomatic HIV-Infected IndividualsKaren Ingrid Tasca0Juliana Trindade Caleffi1Camila Renata Correa2Mariana Gatto3Caio Cavassan de Camargo4Monica Bannwart Mendes5Marjorie de Assis Golim6Mara Biasin7Lenice do Rosário de Souza8Department of Tropical Diseases, Botucatu Medical School (FMB), Universidade Estadual Paulista (UNESP), Botucatu, SP, BrazilDepartment of Tropical Diseases, Botucatu Medical School (FMB), Universidade Estadual Paulista (UNESP), Botucatu, SP, BrazilDepartment of Pathology, FMB/UNESP, Botucatu, SP, BrazilDepartment of Tropical Diseases, Botucatu Medical School (FMB), Universidade Estadual Paulista (UNESP), Botucatu, SP, BrazilDepartment of Tropical Diseases, Botucatu Medical School (FMB), Universidade Estadual Paulista (UNESP), Botucatu, SP, BrazilDepartment of Tropical Diseases, Botucatu Medical School (FMB), Universidade Estadual Paulista (UNESP), Botucatu, SP, BrazilHemocenter, FMB/UNESP, Botucatu, SP, BrazilDepartment of Biomedical and Clinical Sciences, University of Milan, Milan, ItalyDepartment of Tropical Diseases, Botucatu Medical School (FMB), Universidade Estadual Paulista (UNESP), Botucatu, SP, BrazilThe development of the typical comorbidities of aging which currently affects people living with HIV/AIDS (PLWHA) can be partially ascribed to the persistent immune activation and chronic inflammation characterizing these individuals. The aim of this study was to analyze the effect exerted by combined antiretroviral therapy (cART) administration on plasma levels of HMGB1 (high mobility group box protein-1), AGEs (advanced glycation end products), their soluble receptor sRAGE, cytokines, C-reactive protein (CRP), and some metabolic markers in asymptomatic PLWHA. Analyses were performed longitudinally in 30 PLWHA, before and about 6–12 months after cART initiation. We observed that lower levels of AGEs in post-cART group were accompanied by an increase of CRP and triglyceride levels already in the early months of therapy. Because of the current ever-earlier recommendations to start cART and its prolonged use, these and other markers should be investigated in order to monitor and postpone the appearance of non-AIDS comorbidities in PLWHA.http://dx.doi.org/10.1155/2016/2909576 |
| spellingShingle | Karen Ingrid Tasca Juliana Trindade Caleffi Camila Renata Correa Mariana Gatto Caio Cavassan de Camargo Monica Bannwart Mendes Marjorie de Assis Golim Mara Biasin Lenice do Rosário de Souza The Initial Months of Antiretroviral Therapy and Its Influence on AGEs, HMGB1, and sRAGE Levels in Asymptomatic HIV-Infected Individuals Mediators of Inflammation |
| title | The Initial Months of Antiretroviral Therapy and Its Influence on AGEs, HMGB1, and sRAGE Levels in Asymptomatic HIV-Infected Individuals |
| title_full | The Initial Months of Antiretroviral Therapy and Its Influence on AGEs, HMGB1, and sRAGE Levels in Asymptomatic HIV-Infected Individuals |
| title_fullStr | The Initial Months of Antiretroviral Therapy and Its Influence on AGEs, HMGB1, and sRAGE Levels in Asymptomatic HIV-Infected Individuals |
| title_full_unstemmed | The Initial Months of Antiretroviral Therapy and Its Influence on AGEs, HMGB1, and sRAGE Levels in Asymptomatic HIV-Infected Individuals |
| title_short | The Initial Months of Antiretroviral Therapy and Its Influence on AGEs, HMGB1, and sRAGE Levels in Asymptomatic HIV-Infected Individuals |
| title_sort | initial months of antiretroviral therapy and its influence on ages hmgb1 and srage levels in asymptomatic hiv infected individuals |
| url | http://dx.doi.org/10.1155/2016/2909576 |
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