Immunotherapy of small cell lung cancer based on prognostic nutritional index
Platinum-based first-line chemotherapy for small lung cancers has been a mainstream therapy for the past several decades. However, its efficacy has been suboptimal, and the research is now focused on improving the treatment and prognosis of competitive nutrition and multidrug combination techniques....
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-05-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1560241/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849325434506838016 |
|---|---|
| author | Xinling Zhang Yaxuan Zhang Jiaqi Zhang Jinghua Yuan Shuying Zhu Xiaoping Li |
| author_facet | Xinling Zhang Yaxuan Zhang Jiaqi Zhang Jinghua Yuan Shuying Zhu Xiaoping Li |
| author_sort | Xinling Zhang |
| collection | DOAJ |
| description | Platinum-based first-line chemotherapy for small lung cancers has been a mainstream therapy for the past several decades. However, its efficacy has been suboptimal, and the research is now focused on improving the treatment and prognosis of competitive nutrition and multidrug combination techniques. Small cell lung cancer (SCLC) is not only affected by smoking, age, sex and other external factors, but also the tumor micro-environment and the nutritional status of patients themselves are of great significance for the prevention and treatment of SCLC, a malignant tumor. According to past research, malnutrition is related to the intolerance to immunotherapy, decline in quality of life, psychological disturbances, and low survival rates and prognosis. Numerous studies have shown that a low Prognostic Nutritional Index (PNI) serves as an independent prognostic factor linked to reduced overall survival across various cancer types. Additionally, PNI has been associated with disease-free survival and progression-free survival in certain cancers, such as lung cancer (LC). Recent research has indicated that the PNI can serve as an independent predictor of both long-term outcomes and short-term complications in SCLC patients. However, a systematic consensus on this matter has yet to be established. This paper focuses on the role and influence of PNI in the immunotherapy of SCLC, and proposes the possibility of dietary therapy for SCLC patients under the guidance of PNI. Finally, the authors pointed out that PNI will become a new strategy for comprehensive immunotherapy of SCLC. |
| format | Article |
| id | doaj-art-c974ae557d234bc18b59e87e3bd1fdac |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-c974ae557d234bc18b59e87e3bd1fdac2025-08-20T03:48:23ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-05-011610.3389/fimmu.2025.15602411560241Immunotherapy of small cell lung cancer based on prognostic nutritional indexXinling Zhang0Yaxuan Zhang1Jiaqi Zhang2Jinghua Yuan3Shuying Zhu4Xiaoping Li5Key Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Shulan International Medical College, Zhejiang Shuren University, Hangzhou, ChinaKey Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Shulan International Medical College, Zhejiang Shuren University, Hangzhou, ChinaKey Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Shulan International Medical College, Zhejiang Shuren University, Hangzhou, ChinaKey Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Shulan International Medical College, Zhejiang Shuren University, Hangzhou, ChinaDepartment of Microbiology Laboratory, Yiwu Center for Disease Prevention and Control, Yiwu, ChinaKey Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Shulan International Medical College, Zhejiang Shuren University, Hangzhou, ChinaPlatinum-based first-line chemotherapy for small lung cancers has been a mainstream therapy for the past several decades. However, its efficacy has been suboptimal, and the research is now focused on improving the treatment and prognosis of competitive nutrition and multidrug combination techniques. Small cell lung cancer (SCLC) is not only affected by smoking, age, sex and other external factors, but also the tumor micro-environment and the nutritional status of patients themselves are of great significance for the prevention and treatment of SCLC, a malignant tumor. According to past research, malnutrition is related to the intolerance to immunotherapy, decline in quality of life, psychological disturbances, and low survival rates and prognosis. Numerous studies have shown that a low Prognostic Nutritional Index (PNI) serves as an independent prognostic factor linked to reduced overall survival across various cancer types. Additionally, PNI has been associated with disease-free survival and progression-free survival in certain cancers, such as lung cancer (LC). Recent research has indicated that the PNI can serve as an independent predictor of both long-term outcomes and short-term complications in SCLC patients. However, a systematic consensus on this matter has yet to be established. This paper focuses on the role and influence of PNI in the immunotherapy of SCLC, and proposes the possibility of dietary therapy for SCLC patients under the guidance of PNI. Finally, the authors pointed out that PNI will become a new strategy for comprehensive immunotherapy of SCLC.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1560241/fullsmall lung cancernutritionimmunotherapydietprognostic nutritional index |
| spellingShingle | Xinling Zhang Yaxuan Zhang Jiaqi Zhang Jinghua Yuan Shuying Zhu Xiaoping Li Immunotherapy of small cell lung cancer based on prognostic nutritional index Frontiers in Immunology small lung cancer nutrition immunotherapy diet prognostic nutritional index |
| title | Immunotherapy of small cell lung cancer based on prognostic nutritional index |
| title_full | Immunotherapy of small cell lung cancer based on prognostic nutritional index |
| title_fullStr | Immunotherapy of small cell lung cancer based on prognostic nutritional index |
| title_full_unstemmed | Immunotherapy of small cell lung cancer based on prognostic nutritional index |
| title_short | Immunotherapy of small cell lung cancer based on prognostic nutritional index |
| title_sort | immunotherapy of small cell lung cancer based on prognostic nutritional index |
| topic | small lung cancer nutrition immunotherapy diet prognostic nutritional index |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1560241/full |
| work_keys_str_mv | AT xinlingzhang immunotherapyofsmallcelllungcancerbasedonprognosticnutritionalindex AT yaxuanzhang immunotherapyofsmallcelllungcancerbasedonprognosticnutritionalindex AT jiaqizhang immunotherapyofsmallcelllungcancerbasedonprognosticnutritionalindex AT jinghuayuan immunotherapyofsmallcelllungcancerbasedonprognosticnutritionalindex AT shuyingzhu immunotherapyofsmallcelllungcancerbasedonprognosticnutritionalindex AT xiaopingli immunotherapyofsmallcelllungcancerbasedonprognosticnutritionalindex |