The combination of the 18F-FDG PET and susceptibility-weighted imaging for diagnosis of cerebral glucose metabolism and iron deposition in Parkinson’s disease
Abstract This study aimed to evaluate the diagnostic potential of combining 18F-FDG PET and susceptibility-weighted imaging (SWI) to assess cerebral glucose metabolism and iron deposition patterns in Parkinson’s disease (PD), and to determine their correlations with clinical progression and diagnost...
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Nature Portfolio
2025-06-01
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| author | Zhibing He Chao Yang Ling Zhou Shuang Li |
| author_facet | Zhibing He Chao Yang Ling Zhou Shuang Li |
| author_sort | Zhibing He |
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| description | Abstract This study aimed to evaluate the diagnostic potential of combining 18F-FDG PET and susceptibility-weighted imaging (SWI) to assess cerebral glucose metabolism and iron deposition patterns in Parkinson’s disease (PD), and to determine their correlations with clinical progression and diagnostic accuracy. Forty-nine PD patients and 70 age-/sex-matched healthy controls underwent standardized 18F-FDG PET and SWI. Metabolic activity (SUVR) and SWI phase values were quantified in cortical/subcortical regions. Statistical analyses included Mann–Whitney U tests, Pearson/Spearman correlations, and ROC curve analysis to evaluate biomarker-clinical relationships and diagnostic performance. PD patients exhibited hypometabolism in frontal, parietal, and temporal cortices (P < 0.05) and hypermetabolism in the putamen, globus pallidus, and cerebellum (P < 0.05). Cortical hypometabolism correlated with Hoehn-Yahr (H-Y) stages (e.g., temporal lobe: r = − 0.405, P = 0.004) and UPDRS III scores (e.g., frontal cortex: r = − 0.364, P = 0.011). SWI revealed reduced phase values in the substantia nigra, red nucleus, and basal ganglia (P < 0.001), with substantia nigra phase values strongly correlating with H-Y stages (r = − 0.525) and UPDRS III scores (r = − 0.446). Multimodal integration of 18F-FDG PET and SWI achieved superior diagnostic accuracy (AUC = 0.844) compared to single-modality models (PET: AUC = 0.777; SWI: AUC = 0.780, P < 0.0001). The integration of 18F-FDG PET and SWI enhances PD diagnosis by capturing complementary metabolic and iron deposition biomarkers. Cortical hypometabolism may precede subcortical iron accumulation, aligning with Braak staging theory. Limitations include cross-sectional design and technical constraints in SWI quantification. Future studies should validate these findings with longitudinal cohorts and advanced techniques like QSM. |
| format | Article |
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| language | English |
| publishDate | 2025-06-01 |
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| spelling | doaj-art-c970ff1b59f64017b52d3b80d60ca31f2025-08-20T02:05:38ZengNature PortfolioScientific Reports2045-23222025-06-0115111010.1038/s41598-025-02672-xThe combination of the 18F-FDG PET and susceptibility-weighted imaging for diagnosis of cerebral glucose metabolism and iron deposition in Parkinson’s diseaseZhibing He0Chao Yang1Ling Zhou2Shuang Li3Department of Nuclear Medicine, Xiangyang No. 1 People’s Hospital, Hubei University of MedicineDepartment of Nuclear Medicine, Xiangyang No. 1 People’s Hospital, Hubei University of MedicineDepartment of Radiology, Xiangyang No. 1 People’s Hospital, Hubei University of MedicineDepartment of Nuclear Medicine, Xiangyang No. 1 People’s Hospital, Hubei University of MedicineAbstract This study aimed to evaluate the diagnostic potential of combining 18F-FDG PET and susceptibility-weighted imaging (SWI) to assess cerebral glucose metabolism and iron deposition patterns in Parkinson’s disease (PD), and to determine their correlations with clinical progression and diagnostic accuracy. Forty-nine PD patients and 70 age-/sex-matched healthy controls underwent standardized 18F-FDG PET and SWI. Metabolic activity (SUVR) and SWI phase values were quantified in cortical/subcortical regions. Statistical analyses included Mann–Whitney U tests, Pearson/Spearman correlations, and ROC curve analysis to evaluate biomarker-clinical relationships and diagnostic performance. PD patients exhibited hypometabolism in frontal, parietal, and temporal cortices (P < 0.05) and hypermetabolism in the putamen, globus pallidus, and cerebellum (P < 0.05). Cortical hypometabolism correlated with Hoehn-Yahr (H-Y) stages (e.g., temporal lobe: r = − 0.405, P = 0.004) and UPDRS III scores (e.g., frontal cortex: r = − 0.364, P = 0.011). SWI revealed reduced phase values in the substantia nigra, red nucleus, and basal ganglia (P < 0.001), with substantia nigra phase values strongly correlating with H-Y stages (r = − 0.525) and UPDRS III scores (r = − 0.446). Multimodal integration of 18F-FDG PET and SWI achieved superior diagnostic accuracy (AUC = 0.844) compared to single-modality models (PET: AUC = 0.777; SWI: AUC = 0.780, P < 0.0001). The integration of 18F-FDG PET and SWI enhances PD diagnosis by capturing complementary metabolic and iron deposition biomarkers. Cortical hypometabolism may precede subcortical iron accumulation, aligning with Braak staging theory. Limitations include cross-sectional design and technical constraints in SWI quantification. Future studies should validate these findings with longitudinal cohorts and advanced techniques like QSM.https://doi.org/10.1038/s41598-025-02672-xParkinson’s disease18F-FDG PETSusceptibility-weighted imagingMultimodal biomarkersDiagnostic accuracyIron deposition |
| spellingShingle | Zhibing He Chao Yang Ling Zhou Shuang Li The combination of the 18F-FDG PET and susceptibility-weighted imaging for diagnosis of cerebral glucose metabolism and iron deposition in Parkinson’s disease Scientific Reports Parkinson’s disease 18F-FDG PET Susceptibility-weighted imaging Multimodal biomarkers Diagnostic accuracy Iron deposition |
| title | The combination of the 18F-FDG PET and susceptibility-weighted imaging for diagnosis of cerebral glucose metabolism and iron deposition in Parkinson’s disease |
| title_full | The combination of the 18F-FDG PET and susceptibility-weighted imaging for diagnosis of cerebral glucose metabolism and iron deposition in Parkinson’s disease |
| title_fullStr | The combination of the 18F-FDG PET and susceptibility-weighted imaging for diagnosis of cerebral glucose metabolism and iron deposition in Parkinson’s disease |
| title_full_unstemmed | The combination of the 18F-FDG PET and susceptibility-weighted imaging for diagnosis of cerebral glucose metabolism and iron deposition in Parkinson’s disease |
| title_short | The combination of the 18F-FDG PET and susceptibility-weighted imaging for diagnosis of cerebral glucose metabolism and iron deposition in Parkinson’s disease |
| title_sort | combination of the 18f fdg pet and susceptibility weighted imaging for diagnosis of cerebral glucose metabolism and iron deposition in parkinson s disease |
| topic | Parkinson’s disease 18F-FDG PET Susceptibility-weighted imaging Multimodal biomarkers Diagnostic accuracy Iron deposition |
| url | https://doi.org/10.1038/s41598-025-02672-x |
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