DNA methylation memory of pancreatic acinar-ductal metaplasia transition state altering Kras-downstream PI3K and Rho GTPase signaling in the absence of Kras mutation

DNA methylation memory of pancreatic acinar-ductal metaplasia transition state altering Kras-downstream PI3K and Rho GTPase signaling in the absence of Kras mutation

Abstract Background A critical area of recent cancer research is the emergence of transition states between normal and cancer that exhibit increased cell plasticity which underlies tumor cell heterogeneity. Pancreatic ductal adenocarcinoma (PDAC) can arise from the combination of a transition state...

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Bibliographic Details
Main Authors: Emily K.W. Lo, Adrian Idrizi, Rakel Tryggvadottir, Weiqiang Zhou, Wenpin Hou, Hongkai Ji, Patrick Cahan, Andrew P. Feinberg
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Genome Medicine
Subjects:
Pancreatic cancer
DNA methylation
Epigenetic memory
Online Access:https://doi.org/10.1186/s13073-025-01452-6
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