IFIT3: a crucial mediator in innate immunity and tumor progression with therapeutic implications
Interferon-Induced Protein with Tetratricopeptide Repeats 3 (IFIT3) plays a dual role in innate immunity and tumor immunity, functioning as both a viral defense molecule and a regulator of tumor progression. This review explores the mechanisms through which IFIT3 modulates immune responses, includin...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1515718/full |
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| author | Rihan Wu Rihan Wu Hao Yang Hao Yang Chunlei Liu |
| author_facet | Rihan Wu Rihan Wu Hao Yang Hao Yang Chunlei Liu |
| author_sort | Rihan Wu |
| collection | DOAJ |
| description | Interferon-Induced Protein with Tetratricopeptide Repeats 3 (IFIT3) plays a dual role in innate immunity and tumor immunity, functioning as both a viral defense molecule and a regulator of tumor progression. This review explores the mechanisms through which IFIT3 modulates immune responses, including interferon signaling, RIG-I-like receptors, and the NF-κB pathway. IFIT3 facilitates immune evasion and promotes inflammation-mediated tumor growth by regulating immune checkpoints and the tumor microenvironment, its emerging role as a target for cancer immunotherapy opens new avenues for therapeutic strategies. Finally, this paper underscores IFIT3’s potential clinical applications in the modulation of tumor immunity, highlighting the need for further research on IFIT3-targeted therapies. |
| format | Article |
| id | doaj-art-c96ea7649953494b8de1b5472f538cd6 |
| institution | DOAJ |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-c96ea7649953494b8de1b5472f538cd62025-08-20T02:45:02ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-02-011610.3389/fimmu.2025.15157181515718IFIT3: a crucial mediator in innate immunity and tumor progression with therapeutic implicationsRihan Wu0Rihan Wu1Hao Yang2Hao Yang3Chunlei Liu4Department of Radiation Oncology, Peking University Cancer Hospital (Inner Mongolia Campus) & Affiliated Cancer Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region, ChinaGraduate School, Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region, ChinaDepartment of Radiation Oncology, Peking University Cancer Hospital (Inner Mongolia Campus) & Affiliated Cancer Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region, ChinaGraduate School, Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region, ChinaTranslational Medicine Research Center, Medical Innovation Research Division of Chinese PLA General Hospital, Beijing, ChinaInterferon-Induced Protein with Tetratricopeptide Repeats 3 (IFIT3) plays a dual role in innate immunity and tumor immunity, functioning as both a viral defense molecule and a regulator of tumor progression. This review explores the mechanisms through which IFIT3 modulates immune responses, including interferon signaling, RIG-I-like receptors, and the NF-κB pathway. IFIT3 facilitates immune evasion and promotes inflammation-mediated tumor growth by regulating immune checkpoints and the tumor microenvironment, its emerging role as a target for cancer immunotherapy opens new avenues for therapeutic strategies. Finally, this paper underscores IFIT3’s potential clinical applications in the modulation of tumor immunity, highlighting the need for further research on IFIT3-targeted therapies.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1515718/fullIFIT3tumor immunitycancer progressioninnate immunityimmunotherapy |
| spellingShingle | Rihan Wu Rihan Wu Hao Yang Hao Yang Chunlei Liu IFIT3: a crucial mediator in innate immunity and tumor progression with therapeutic implications Frontiers in Immunology IFIT3 tumor immunity cancer progression innate immunity immunotherapy |
| title | IFIT3: a crucial mediator in innate immunity and tumor progression with therapeutic implications |
| title_full | IFIT3: a crucial mediator in innate immunity and tumor progression with therapeutic implications |
| title_fullStr | IFIT3: a crucial mediator in innate immunity and tumor progression with therapeutic implications |
| title_full_unstemmed | IFIT3: a crucial mediator in innate immunity and tumor progression with therapeutic implications |
| title_short | IFIT3: a crucial mediator in innate immunity and tumor progression with therapeutic implications |
| title_sort | ifit3 a crucial mediator in innate immunity and tumor progression with therapeutic implications |
| topic | IFIT3 tumor immunity cancer progression innate immunity immunotherapy |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1515718/full |
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