Gossypol Promotes Degeneration of Ovarian Follicles in Rats
The present study aimed to determine if gossypol interferes with ovarian follicles in rats. Twenty-four female Wistar rats were assigned to two equal groups: one control group and the other dosed with gossypol (25 mg/kg/day, subcutaneously) for 15 days. Ovarian follicles were histologically classifi...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/986184 |
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| author | Ivana Cristina Nunes Gadelha Michelly Fernandes de Macedo Sílvia Catarina Salgado Oloris Marilia Martins Melo Benito Soto-Blanco |
| author_facet | Ivana Cristina Nunes Gadelha Michelly Fernandes de Macedo Sílvia Catarina Salgado Oloris Marilia Martins Melo Benito Soto-Blanco |
| author_sort | Ivana Cristina Nunes Gadelha |
| collection | DOAJ |
| description | The present study aimed to determine if gossypol interferes with ovarian follicles in rats. Twenty-four female Wistar rats were assigned to two equal groups: one control group and the other dosed with gossypol (25 mg/kg/day, subcutaneously) for 15 days. Ovarian follicles were histologically classified according to the stage of development and as normal or atretic. Gossypol treatment reduced the length of estrous with an increase in the duration of the diestrus phase. This compound was responsible for reduced serum levels of T4 and progesterone. Treatment with gossypol was responsible for a significant reduction in the number of normal ovarian follicles and a significant increase in the number of atretic follicles, both in all stages of development. Thus, treatment of rats with gossypol was responsible for reduction in the number of viable follicles and changes in hormone levels that resulted in interference of the estrous cycle. |
| format | Article |
| id | doaj-art-c96d77a85b2f4132984f5256440a6cc8 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-c96d77a85b2f4132984f5256440a6cc82025-02-03T00:59:18ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/986184986184Gossypol Promotes Degeneration of Ovarian Follicles in RatsIvana Cristina Nunes Gadelha0Michelly Fernandes de Macedo1Sílvia Catarina Salgado Oloris2Marilia Martins Melo3Benito Soto-Blanco4Programa de Pós-graduação em Ciência Animal, Universidade Federal Rural do Semiárido, BR 110 Km 47, 59628-360 Mossoró, RN, BrazilPrograma de Pós-graduação em Ciência Animal, Universidade Federal Rural do Semiárido, BR 110 Km 47, 59628-360 Mossoró, RN, BrazilFundação Ezequiel Dias (FUNED), Rua Conde Pereira Carneiro 80, 30510-010 Belo Horizonte, MG, BrazilDepartamento de Clínica e Cirurgia Veterinárias, Escola de Veterinária, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6627, 30123-970 Belo Horizonte, MG, BrazilDepartamento de Clínica e Cirurgia Veterinárias, Escola de Veterinária, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6627, 30123-970 Belo Horizonte, MG, BrazilThe present study aimed to determine if gossypol interferes with ovarian follicles in rats. Twenty-four female Wistar rats were assigned to two equal groups: one control group and the other dosed with gossypol (25 mg/kg/day, subcutaneously) for 15 days. Ovarian follicles were histologically classified according to the stage of development and as normal or atretic. Gossypol treatment reduced the length of estrous with an increase in the duration of the diestrus phase. This compound was responsible for reduced serum levels of T4 and progesterone. Treatment with gossypol was responsible for a significant reduction in the number of normal ovarian follicles and a significant increase in the number of atretic follicles, both in all stages of development. Thus, treatment of rats with gossypol was responsible for reduction in the number of viable follicles and changes in hormone levels that resulted in interference of the estrous cycle.http://dx.doi.org/10.1155/2014/986184 |
| spellingShingle | Ivana Cristina Nunes Gadelha Michelly Fernandes de Macedo Sílvia Catarina Salgado Oloris Marilia Martins Melo Benito Soto-Blanco Gossypol Promotes Degeneration of Ovarian Follicles in Rats The Scientific World Journal |
| title | Gossypol Promotes Degeneration of Ovarian Follicles in Rats |
| title_full | Gossypol Promotes Degeneration of Ovarian Follicles in Rats |
| title_fullStr | Gossypol Promotes Degeneration of Ovarian Follicles in Rats |
| title_full_unstemmed | Gossypol Promotes Degeneration of Ovarian Follicles in Rats |
| title_short | Gossypol Promotes Degeneration of Ovarian Follicles in Rats |
| title_sort | gossypol promotes degeneration of ovarian follicles in rats |
| url | http://dx.doi.org/10.1155/2014/986184 |
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