Leprosy late-onset neuropathy: an uncommon presentation of leprosy
Clinical and pathological findings in leprosy are determined by the natural host immune response to Mycobacterium leprae. We previously described cases of painful neuropathy (PN) with no concurrent cause apart from a past history of leprosy successfully treated. Four leprosy previously treated patie...
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| Format: | Article |
| Language: | English |
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Thieme Revinter Publicações
2012-06-01
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| Series: | Arquivos de Neuro-Psiquiatria |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012000600004&lng=en&tlng=en |
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| author | Osvaldo J.M. Nascimento Marcos R. G. de Freitas Tania Escada Wilson Marques Junior Fernando Cardoso Camila Pupe Sandra Duraes |
| author_facet | Osvaldo J.M. Nascimento Marcos R. G. de Freitas Tania Escada Wilson Marques Junior Fernando Cardoso Camila Pupe Sandra Duraes |
| author_sort | Osvaldo J.M. Nascimento |
| collection | DOAJ |
| description | Clinical and pathological findings in leprosy are determined by the natural host immune response to Mycobacterium leprae. We previously described cases of painful neuropathy (PN) with no concurrent cause apart from a past history of leprosy successfully treated. Four leprosy previously treated patients who developed a PN years after multidrug therapy (MDT) are reported. The mean patient age was 52.75 years (47-64). The mean time interval of the recent neuropathy from the previous MDT was 19 years (12-26). A painful multiplex neuritis or polyneuropathy were observed respectively in two cases. Electrophysiological studies disclosed a sensory axonal neuropathy in two cases. Microvasculitis with no bacilli was seen in nerve biopsy. Neuropathic symptoms were improved with prednisone. We consider these cases as being a leprosy late-onset neuropathy (LLON) form of presentation. A delayed immune reaction could explain the late appearance of LLON. |
| format | Article |
| id | doaj-art-c968a67f28d841989fef218fbc3ffab3 |
| institution | DOAJ |
| issn | 1678-4227 |
| language | English |
| publishDate | 2012-06-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-c968a67f28d841989fef218fbc3ffab32025-08-20T03:19:34ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-42272012-06-0170640440610.1590/S0004-282X2012000600004S0004-282X2012000600004Leprosy late-onset neuropathy: an uncommon presentation of leprosyOsvaldo J.M. Nascimento0Marcos R. G. de Freitas1Tania Escada2Wilson Marques Junior3Fernando Cardoso4Camila Pupe5Sandra Duraes6Universidade Federal FluminenseUniversidade Federal FluminenseUniversidade Federal FluminenseUniversidade Federal FluminenseUniversidade Federal FluminenseUniversidade Federal FluminenseUniversidade Federal FluminenseClinical and pathological findings in leprosy are determined by the natural host immune response to Mycobacterium leprae. We previously described cases of painful neuropathy (PN) with no concurrent cause apart from a past history of leprosy successfully treated. Four leprosy previously treated patients who developed a PN years after multidrug therapy (MDT) are reported. The mean patient age was 52.75 years (47-64). The mean time interval of the recent neuropathy from the previous MDT was 19 years (12-26). A painful multiplex neuritis or polyneuropathy were observed respectively in two cases. Electrophysiological studies disclosed a sensory axonal neuropathy in two cases. Microvasculitis with no bacilli was seen in nerve biopsy. Neuropathic symptoms were improved with prednisone. We consider these cases as being a leprosy late-onset neuropathy (LLON) form of presentation. A delayed immune reaction could explain the late appearance of LLON.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012000600004&lng=en&tlng=enhanseníaseneuropatia de início tardiocondução nervosaterapia |
| spellingShingle | Osvaldo J.M. Nascimento Marcos R. G. de Freitas Tania Escada Wilson Marques Junior Fernando Cardoso Camila Pupe Sandra Duraes Leprosy late-onset neuropathy: an uncommon presentation of leprosy Arquivos de Neuro-Psiquiatria hanseníase neuropatia de início tardio condução nervosa terapia |
| title | Leprosy late-onset neuropathy: an uncommon presentation of leprosy |
| title_full | Leprosy late-onset neuropathy: an uncommon presentation of leprosy |
| title_fullStr | Leprosy late-onset neuropathy: an uncommon presentation of leprosy |
| title_full_unstemmed | Leprosy late-onset neuropathy: an uncommon presentation of leprosy |
| title_short | Leprosy late-onset neuropathy: an uncommon presentation of leprosy |
| title_sort | leprosy late onset neuropathy an uncommon presentation of leprosy |
| topic | hanseníase neuropatia de início tardio condução nervosa terapia |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012000600004&lng=en&tlng=en |
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