Novel mitophagy inducer TJ0113 alleviates pulmonary inflammation during acute lung injury

Novel mitophagy inducer TJ0113 alleviates pulmonary inflammation during acute lung injury

IntroductionAcute lung injury (ALI) is a severe respiratory disease with limited effective therapeutic options. Recent studies have highlighted mitochondrial damage as a crucial factor in the progression of ALI. Mitophagy, which facilitates the removal of damaged mitochondria, has been shown to redu...

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Bibliographic Details
Main Authors: Zhengyuan Liu, Danruo Fang, Kaijun Chen, Lingling Dong, Huaqiong Huang, Zhihua Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Pharmacology
Subjects:
acute lung injury
mitophagy inducer
TJ0113
NF-κB
NLRP3 inflammasome
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1590458/full
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