Gene Expression Profiling for In Silico Microdissection of Hodgkin's Lymphoma Microenvironment and Identification of Prognostic Features
Gene expression profiling studies based on DNA microarrays have demonstrated their ability to define the interaction pathways between neoplastic and nonmalignant stromal cells in cancer tissues. During the past ten years, a number of approaches including microdissection have tried to resolve the var...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
|
| Series: | Advances in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2011/485310 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849696037344641024 |
|---|---|
| author | François Bertucci Bruno Chetaille Luc Xerri |
| author_facet | François Bertucci Bruno Chetaille Luc Xerri |
| author_sort | François Bertucci |
| collection | DOAJ |
| description | Gene expression profiling studies based on DNA microarrays have demonstrated their ability to define the interaction pathways between neoplastic and nonmalignant stromal cells in cancer tissues. During the past ten years, a number of approaches including microdissection have tried to resolve the variability in DNA microarray measurements stemming from cancer tissue sample heterogeneity. Another approach, designated as virtual or in silico microdissection, avoids the laborious and time-consuming step of anatomic microdissection. It consists of confronting the gene expression profiles of complex tissue samples to those of cell lines representative of different cell lineages, different differentiation stages, or different signaling pathways. This strategy has been used in recent studies aiming to analyze microenvironment alterations using gene expression profiling of nonmicrodissected classical Hodgkin lymphoma tissues in order to generate new prognostic factors. These recent contributions are detailed and discussed in the present paper. |
| format | Article |
| id | doaj-art-c9646acb9abb468dbbe2785fe6dc211b |
| institution | DOAJ |
| issn | 1687-9104 1687-9112 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Hematology |
| spelling | doaj-art-c9646acb9abb468dbbe2785fe6dc211b2025-08-20T03:19:34ZengWileyAdvances in Hematology1687-91041687-91122011-01-01201110.1155/2011/485310485310Gene Expression Profiling for In Silico Microdissection of Hodgkin's Lymphoma Microenvironment and Identification of Prognostic FeaturesFrançois Bertucci0Bruno Chetaille1Luc Xerri2Department of Bio-Pathology, Institut Paoli-Calmettes, 232, bd Sainte-Marguerite, 13273 Marseille Cedex 09, FranceDepartment of Bio-Pathology, Institut Paoli-Calmettes, 232, bd Sainte-Marguerite, 13273 Marseille Cedex 09, FranceDepartment of Bio-Pathology, Institut Paoli-Calmettes, 232, bd Sainte-Marguerite, 13273 Marseille Cedex 09, FranceGene expression profiling studies based on DNA microarrays have demonstrated their ability to define the interaction pathways between neoplastic and nonmalignant stromal cells in cancer tissues. During the past ten years, a number of approaches including microdissection have tried to resolve the variability in DNA microarray measurements stemming from cancer tissue sample heterogeneity. Another approach, designated as virtual or in silico microdissection, avoids the laborious and time-consuming step of anatomic microdissection. It consists of confronting the gene expression profiles of complex tissue samples to those of cell lines representative of different cell lineages, different differentiation stages, or different signaling pathways. This strategy has been used in recent studies aiming to analyze microenvironment alterations using gene expression profiling of nonmicrodissected classical Hodgkin lymphoma tissues in order to generate new prognostic factors. These recent contributions are detailed and discussed in the present paper.http://dx.doi.org/10.1155/2011/485310 |
| spellingShingle | François Bertucci Bruno Chetaille Luc Xerri Gene Expression Profiling for In Silico Microdissection of Hodgkin's Lymphoma Microenvironment and Identification of Prognostic Features Advances in Hematology |
| title | Gene Expression Profiling for In Silico Microdissection of Hodgkin's Lymphoma Microenvironment and Identification of Prognostic Features |
| title_full | Gene Expression Profiling for In Silico Microdissection of Hodgkin's Lymphoma Microenvironment and Identification of Prognostic Features |
| title_fullStr | Gene Expression Profiling for In Silico Microdissection of Hodgkin's Lymphoma Microenvironment and Identification of Prognostic Features |
| title_full_unstemmed | Gene Expression Profiling for In Silico Microdissection of Hodgkin's Lymphoma Microenvironment and Identification of Prognostic Features |
| title_short | Gene Expression Profiling for In Silico Microdissection of Hodgkin's Lymphoma Microenvironment and Identification of Prognostic Features |
| title_sort | gene expression profiling for in silico microdissection of hodgkin s lymphoma microenvironment and identification of prognostic features |
| url | http://dx.doi.org/10.1155/2011/485310 |
| work_keys_str_mv | AT francoisbertucci geneexpressionprofilingforinsilicomicrodissectionofhodgkinslymphomamicroenvironmentandidentificationofprognosticfeatures AT brunochetaille geneexpressionprofilingforinsilicomicrodissectionofhodgkinslymphomamicroenvironmentandidentificationofprognosticfeatures AT lucxerri geneexpressionprofilingforinsilicomicrodissectionofhodgkinslymphomamicroenvironmentandidentificationofprognosticfeatures |