Age and gender related changes on total antioxidant/oxidant status and electrolyte composition of saliva
Background: Saliva is used as an important biological material in the diagnosis and treatment of various diseases to collect easily, to be cheap, to have a minimal risk of infection. Here in that study we aimed to evaluate age and gender-related changes on total antioxidant/oxidant status and electr...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Aspects of Molecular Medicine |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2949688824000212 |
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| author | Erdal Ergünol Rabia Şemsi Aylin Sepici Dinçel |
| author_facet | Erdal Ergünol Rabia Şemsi Aylin Sepici Dinçel |
| author_sort | Erdal Ergünol |
| collection | DOAJ |
| description | Background: Saliva is used as an important biological material in the diagnosis and treatment of various diseases to collect easily, to be cheap, to have a minimal risk of infection. Here in that study we aimed to evaluate age and gender-related changes on total antioxidant/oxidant status and electrolyte composition of saliva levels in individuals. Methods: A total of 30 young adult (21.2 ± 2.47 years) and 14 adult (51.6 ± 9.35 years) subjects were included in the study. Stimulated saliva samples were collected. Cortisol, amylase, oxidative stress biomarkers (total antioxidant status and total oxidant status) were measured by ELISA and spectrophotometric manual methods and electrolyte level of saliva samples were determined by autoanalyzer. Results: Salivary concentrations of biomarkers of young adults were compared to adult subjects, there was a statistically significant difference between cortisol (μg/dL) (p = 0.003), Ca+2(mg/dL) (p = 0.004), TAS (mmol Trolox Equiv/L) (p = 0.001), BUN (mg/dL) (p = 0.02), Mg+2 (mg/dL) (p = 0.02), and K+ (mmol/L) (p = 0.05) levels, but there was no significant difference was found between uric acid (mg/dL) (p = 0.44), Cl- (mmol/L) (p = 0.07), amylase (ng/mL) (p = 0.47), phosphate (mg/dL) (p = 0.63), Na+(mmol/L)(p = 0.21), and TOS (μmol H2O2 Equiv/L) (p = 0.70) levels. We evaluated salivary cortisol, amylase, and electrolyte levels of groups that we commented on their relationship between oxidant-antioxidant defense systems of the saliva and their correlations with age and gender. Conclusions: This study could suggest the use of saliva samples to correlate with age and representing the levels of the most common biological parameters for routine use and antioxidant-oxidant enzymes for clinical trials. |
| format | Article |
| id | doaj-art-c963ff0ddeba433f93c2180eb6cf1af0 |
| institution | OA Journals |
| issn | 2949-6888 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Aspects of Molecular Medicine |
| spelling | doaj-art-c963ff0ddeba433f93c2180eb6cf1af02025-08-20T02:19:33ZengElsevierAspects of Molecular Medicine2949-68882024-12-01410005410.1016/j.amolm.2024.100054Age and gender related changes on total antioxidant/oxidant status and electrolyte composition of salivaErdal Ergünol0Rabia Şemsi1Aylin Sepici Dinçel2Department of Oral and Maxillofaxial Surgery, Faculty of Dentistry, Cyprus Health and Social Sciences University, Morphou, North Cyprus; Alter Group, Innovation, Education, Consultation and Organisation Company, İstanbul, TürkiyeDepartment of Medical Biochemistry, Institute of Health Sciences, Gazi University, Ankara, Türkiye; Corresponding author. Department of Medical Biochemistry, Institute of Health Sciences, Gazi University, Ankara, Türkiye.Department of Medical Biochemistry, Faculty of Medicine, Gazi University, Ankara, TürkiyeBackground: Saliva is used as an important biological material in the diagnosis and treatment of various diseases to collect easily, to be cheap, to have a minimal risk of infection. Here in that study we aimed to evaluate age and gender-related changes on total antioxidant/oxidant status and electrolyte composition of saliva levels in individuals. Methods: A total of 30 young adult (21.2 ± 2.47 years) and 14 adult (51.6 ± 9.35 years) subjects were included in the study. Stimulated saliva samples were collected. Cortisol, amylase, oxidative stress biomarkers (total antioxidant status and total oxidant status) were measured by ELISA and spectrophotometric manual methods and electrolyte level of saliva samples were determined by autoanalyzer. Results: Salivary concentrations of biomarkers of young adults were compared to adult subjects, there was a statistically significant difference between cortisol (μg/dL) (p = 0.003), Ca+2(mg/dL) (p = 0.004), TAS (mmol Trolox Equiv/L) (p = 0.001), BUN (mg/dL) (p = 0.02), Mg+2 (mg/dL) (p = 0.02), and K+ (mmol/L) (p = 0.05) levels, but there was no significant difference was found between uric acid (mg/dL) (p = 0.44), Cl- (mmol/L) (p = 0.07), amylase (ng/mL) (p = 0.47), phosphate (mg/dL) (p = 0.63), Na+(mmol/L)(p = 0.21), and TOS (μmol H2O2 Equiv/L) (p = 0.70) levels. We evaluated salivary cortisol, amylase, and electrolyte levels of groups that we commented on their relationship between oxidant-antioxidant defense systems of the saliva and their correlations with age and gender. Conclusions: This study could suggest the use of saliva samples to correlate with age and representing the levels of the most common biological parameters for routine use and antioxidant-oxidant enzymes for clinical trials.http://www.sciencedirect.com/science/article/pii/S2949688824000212 |
| spellingShingle | Erdal Ergünol Rabia Şemsi Aylin Sepici Dinçel Age and gender related changes on total antioxidant/oxidant status and electrolyte composition of saliva Aspects of Molecular Medicine |
| title | Age and gender related changes on total antioxidant/oxidant status and electrolyte composition of saliva |
| title_full | Age and gender related changes on total antioxidant/oxidant status and electrolyte composition of saliva |
| title_fullStr | Age and gender related changes on total antioxidant/oxidant status and electrolyte composition of saliva |
| title_full_unstemmed | Age and gender related changes on total antioxidant/oxidant status and electrolyte composition of saliva |
| title_short | Age and gender related changes on total antioxidant/oxidant status and electrolyte composition of saliva |
| title_sort | age and gender related changes on total antioxidant oxidant status and electrolyte composition of saliva |
| url | http://www.sciencedirect.com/science/article/pii/S2949688824000212 |
| work_keys_str_mv | AT erdalergunol ageandgenderrelatedchangesontotalantioxidantoxidantstatusandelectrolytecompositionofsaliva AT rabiasemsi ageandgenderrelatedchangesontotalantioxidantoxidantstatusandelectrolytecompositionofsaliva AT aylinsepicidincel ageandgenderrelatedchangesontotalantioxidantoxidantstatusandelectrolytecompositionofsaliva |