Population pharmacokinetics and dosing optimization of imipenem in Chinese elderly patients
ObjectivesTo assess the pharmacokinetics and pharmacodynamics of imipenem in a retrospective cohort of hospitalized Chinese older patients.MethodsA population pharmacokinetic (PPK) model was constructed utilizing a nonlinear mixed-effects modeling approach. The final model underwent evaluation throu...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1524272/full |
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| author | Jing Wang Qiu Fang Xuemei Luo Lu Jin Huaijun Zhu Huaijun Zhu |
| author_facet | Jing Wang Qiu Fang Xuemei Luo Lu Jin Huaijun Zhu Huaijun Zhu |
| author_sort | Jing Wang |
| collection | DOAJ |
| description | ObjectivesTo assess the pharmacokinetics and pharmacodynamics of imipenem in a retrospective cohort of hospitalized Chinese older patients.MethodsA population pharmacokinetic (PPK) model was constructed utilizing a nonlinear mixed-effects modeling approach. The final model underwent evaluation through bootstrap resampling and visual predictive checks. Additionally, a population pharmacokinetic and pharmacodynamic analysis was conducted employing Monte Carlo simulations to investigate the impact of commonly used dosing regimens (0.25 g every 6 h, 0.5 g every 6 h, 0.5 g every 8 h, 1 g every 6 h, 1 g every 8 h, and 1 g every 12 h) on the likelihood of achieving the target therapeutic outcomes.ResultsA total of 370 observations available from 142 patients were incorporated in the PPK model. A two-compartment PPK model with linear elimination best predicted the imipenem plasma concentrations, with the creatinine clearance as a significant covariate of clearance. Typical estimates for clearance, inter-compartmental clearance, central and peripheral volume were 13.1 L·h−1, 11.9 L·h−1, 11.7 L, 29.3 L, respectively.ConclusionThe pharmacokinetics of imipenem in elderly patients were effectively characterized by the established PPK model, which includes creatinine clearance as a key covariate. This research will enhance our understanding of imipenem elimination and support precision dosing in this patient demographic. |
| format | Article |
| id | doaj-art-c962e6b9babe4a9eaa98525b00089a56 |
| institution | DOAJ |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-c962e6b9babe4a9eaa98525b00089a562025-08-20T03:12:42ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-01-011510.3389/fphar.2024.15242721524272Population pharmacokinetics and dosing optimization of imipenem in Chinese elderly patientsJing Wang0Qiu Fang1Xuemei Luo2Lu Jin3Huaijun Zhu4Huaijun Zhu5Department of Pharmacy, Nanjing Drum Tower Hospital, Nanjing, Jiangsu, ChinaDepartment of Pharmacy, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, ChinaDepartment of Pharmacy, Nanjing Drum Tower Hospital, Nanjing, Jiangsu, ChinaDepartment of Pharmacy, Nanjing Drum Tower Hospital, Nanjing, Jiangsu, ChinaDepartment of Pharmacy, Nanjing Drum Tower Hospital, Nanjing, Jiangsu, ChinaDepartment of Pharmacy, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, ChinaObjectivesTo assess the pharmacokinetics and pharmacodynamics of imipenem in a retrospective cohort of hospitalized Chinese older patients.MethodsA population pharmacokinetic (PPK) model was constructed utilizing a nonlinear mixed-effects modeling approach. The final model underwent evaluation through bootstrap resampling and visual predictive checks. Additionally, a population pharmacokinetic and pharmacodynamic analysis was conducted employing Monte Carlo simulations to investigate the impact of commonly used dosing regimens (0.25 g every 6 h, 0.5 g every 6 h, 0.5 g every 8 h, 1 g every 6 h, 1 g every 8 h, and 1 g every 12 h) on the likelihood of achieving the target therapeutic outcomes.ResultsA total of 370 observations available from 142 patients were incorporated in the PPK model. A two-compartment PPK model with linear elimination best predicted the imipenem plasma concentrations, with the creatinine clearance as a significant covariate of clearance. Typical estimates for clearance, inter-compartmental clearance, central and peripheral volume were 13.1 L·h−1, 11.9 L·h−1, 11.7 L, 29.3 L, respectively.ConclusionThe pharmacokinetics of imipenem in elderly patients were effectively characterized by the established PPK model, which includes creatinine clearance as a key covariate. This research will enhance our understanding of imipenem elimination and support precision dosing in this patient demographic.https://www.frontiersin.org/articles/10.3389/fphar.2024.1524272/fullimipenempopulation pharmacokineticsdosing optimizationelderly patientsMonte Carlo |
| spellingShingle | Jing Wang Qiu Fang Xuemei Luo Lu Jin Huaijun Zhu Huaijun Zhu Population pharmacokinetics and dosing optimization of imipenem in Chinese elderly patients Frontiers in Pharmacology imipenem population pharmacokinetics dosing optimization elderly patients Monte Carlo |
| title | Population pharmacokinetics and dosing optimization of imipenem in Chinese elderly patients |
| title_full | Population pharmacokinetics and dosing optimization of imipenem in Chinese elderly patients |
| title_fullStr | Population pharmacokinetics and dosing optimization of imipenem in Chinese elderly patients |
| title_full_unstemmed | Population pharmacokinetics and dosing optimization of imipenem in Chinese elderly patients |
| title_short | Population pharmacokinetics and dosing optimization of imipenem in Chinese elderly patients |
| title_sort | population pharmacokinetics and dosing optimization of imipenem in chinese elderly patients |
| topic | imipenem population pharmacokinetics dosing optimization elderly patients Monte Carlo |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1524272/full |
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