Two case reports of MDA5-type seronegative dermatomyositis
Dermatomyositis (DM) is an autoimmune idiopathic inflammatory myopathy with characteristic dermatologic manifestations. Myositis-specific autoantibodies (MSAs) delineate DM subtypes and their prognoses. Uncommonly, patients present with distinct clinical features of DM, including photosensitive derm...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2024-12-01
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| Series: | SAGE Open Medical Case Reports |
| Online Access: | https://doi.org/10.1177/2050313X241309094 |
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| author | Lauren C Balogh Airiss R Chan Elaine A Yacyshyn Robert Gniadecki |
| author_facet | Lauren C Balogh Airiss R Chan Elaine A Yacyshyn Robert Gniadecki |
| author_sort | Lauren C Balogh |
| collection | DOAJ |
| description | Dermatomyositis (DM) is an autoimmune idiopathic inflammatory myopathy with characteristic dermatologic manifestations. Myositis-specific autoantibodies (MSAs) delineate DM subtypes and their prognoses. Uncommonly, patients present with distinct clinical features of DM, including photosensitive dermatitis, heliotrope rash, Gottron’s papules, and nailfold changes; however, their autoimmune serology is negative for expected MSAs. Herein, we describe two unconventional cases of seronegative, amyopathic MDA5-DM and offer potential explanations, including fluctuating antibody levels, non-MSA pathophysiology, and limitations in current immunoassays. |
| format | Article |
| id | doaj-art-c95de034b9b34abd8a47ddaf59202cd9 |
| institution | OA Journals |
| issn | 2050-313X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | SAGE Open Medical Case Reports |
| spelling | doaj-art-c95de034b9b34abd8a47ddaf59202cd92025-08-20T02:31:34ZengSAGE PublishingSAGE Open Medical Case Reports2050-313X2024-12-011210.1177/2050313X241309094Two case reports of MDA5-type seronegative dermatomyositisLauren C Balogh0Airiss R Chan1Elaine A Yacyshyn2Robert Gniadecki3Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, CanadaDivision of Dermatology, Department of Medicine, University of Alberta, Edmonton, AB, CanadaDivision of Rheumatology, Department of Medicine, University of Alberta, Edmonton, AB, CanadaDivision of Dermatology, Department of Medicine, University of Alberta, Edmonton, AB, CanadaDermatomyositis (DM) is an autoimmune idiopathic inflammatory myopathy with characteristic dermatologic manifestations. Myositis-specific autoantibodies (MSAs) delineate DM subtypes and their prognoses. Uncommonly, patients present with distinct clinical features of DM, including photosensitive dermatitis, heliotrope rash, Gottron’s papules, and nailfold changes; however, their autoimmune serology is negative for expected MSAs. Herein, we describe two unconventional cases of seronegative, amyopathic MDA5-DM and offer potential explanations, including fluctuating antibody levels, non-MSA pathophysiology, and limitations in current immunoassays.https://doi.org/10.1177/2050313X241309094 |
| spellingShingle | Lauren C Balogh Airiss R Chan Elaine A Yacyshyn Robert Gniadecki Two case reports of MDA5-type seronegative dermatomyositis SAGE Open Medical Case Reports |
| title | Two case reports of MDA5-type seronegative dermatomyositis |
| title_full | Two case reports of MDA5-type seronegative dermatomyositis |
| title_fullStr | Two case reports of MDA5-type seronegative dermatomyositis |
| title_full_unstemmed | Two case reports of MDA5-type seronegative dermatomyositis |
| title_short | Two case reports of MDA5-type seronegative dermatomyositis |
| title_sort | two case reports of mda5 type seronegative dermatomyositis |
| url | https://doi.org/10.1177/2050313X241309094 |
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