Peroxisome and pexophagy in neurological diseases
Peroxisomes and pexophagy have gained increasing attention in their role within the central nervous system (CNS) in recent years. In this review, we comprehensively discussed the physiological and pathological mechanisms of peroxisomes and pexophagy in neurological diseases. Peroxisomes communicate...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co. Ltd.
2024-11-01
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| Series: | Fundamental Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667325823001425 |
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| author | Weilin Xu Jun Yan Anwen Shao Cameron Lenahan Liansheng Gao Haijian Wu Jingwei Zheng Jianmin Zhang John H. Zhang |
| author_facet | Weilin Xu Jun Yan Anwen Shao Cameron Lenahan Liansheng Gao Haijian Wu Jingwei Zheng Jianmin Zhang John H. Zhang |
| author_sort | Weilin Xu |
| collection | DOAJ |
| description | Peroxisomes and pexophagy have gained increasing attention in their role within the central nervous system (CNS) in recent years. In this review, we comprehensively discussed the physiological and pathological mechanisms of peroxisomes and pexophagy in neurological diseases. Peroxisomes communicate with mitochondria, endoplasmic reticulum, and lipid bodies. Their types, sizes, and shapes vary in different regions of the brain. Moreover, peroxisomes play an important role in oxidative homeostasis, lipid synthesis, and degradation in the CNS, whereas its dysfunction causes various neurological diseases. Therefore, selective removal of dysfunctional or superfluous peroxisomes (pexophagy) provides neuroprotective effects, which indicate a promising therapeutic target. However, pexophagy largely remains unexplored in neurological disorders. More studies are needed to explore the pexophagy's crosstalk mechanisms in neurological pathology. |
| format | Article |
| id | doaj-art-c959bbe1e578480b9cc9b93aed33a032 |
| institution | Kabale University |
| issn | 2667-3258 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | KeAi Communications Co. Ltd. |
| record_format | Article |
| series | Fundamental Research |
| spelling | doaj-art-c959bbe1e578480b9cc9b93aed33a0322024-12-01T05:08:51ZengKeAi Communications Co. Ltd.Fundamental Research2667-32582024-11-014613891397Peroxisome and pexophagy in neurological diseasesWeilin Xu0Jun Yan1Anwen Shao2Cameron Lenahan3Liansheng Gao4Haijian Wu5Jingwei Zheng6Jianmin Zhang7John H. Zhang8Department of Neurosurgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China; Key Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases, Hangzhou 310009, China; Corresponding authors.Department of Neurosurgery, Affiliated Tumor Hospital of Guangxi Medical University, Guangxi 537406, ChinaDepartment of Neurosurgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China; Key Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases, Hangzhou 310009, ChinaBurrell College of Osteopathic Medicine, New Mexico State University, Las Cruces, NM 88001, USADepartment of Neurosurgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China; Key Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases, Hangzhou 310009, ChinaDepartment of Neurosurgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China; Key Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases, Hangzhou 310009, ChinaDepartment of Neurosurgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China; Key Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases, Hangzhou 310009, ChinaDepartment of Neurosurgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China; Key Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases, Hangzhou 310009, ChinaDepartment of Physiology & Pharmacology Loma Linda University, Loma Linda, CA 92350, USA; Department of Neurosurgery Loma Linda University, Loma Linda, CA 92350, USA; Corresponding authors.Peroxisomes and pexophagy have gained increasing attention in their role within the central nervous system (CNS) in recent years. In this review, we comprehensively discussed the physiological and pathological mechanisms of peroxisomes and pexophagy in neurological diseases. Peroxisomes communicate with mitochondria, endoplasmic reticulum, and lipid bodies. Their types, sizes, and shapes vary in different regions of the brain. Moreover, peroxisomes play an important role in oxidative homeostasis, lipid synthesis, and degradation in the CNS, whereas its dysfunction causes various neurological diseases. Therefore, selective removal of dysfunctional or superfluous peroxisomes (pexophagy) provides neuroprotective effects, which indicate a promising therapeutic target. However, pexophagy largely remains unexplored in neurological disorders. More studies are needed to explore the pexophagy's crosstalk mechanisms in neurological pathology.http://www.sciencedirect.com/science/article/pii/S2667325823001425PeroxisomePexophagyAutophagyNeurological diseasesNeuroprotection |
| spellingShingle | Weilin Xu Jun Yan Anwen Shao Cameron Lenahan Liansheng Gao Haijian Wu Jingwei Zheng Jianmin Zhang John H. Zhang Peroxisome and pexophagy in neurological diseases Fundamental Research Peroxisome Pexophagy Autophagy Neurological diseases Neuroprotection |
| title | Peroxisome and pexophagy in neurological diseases |
| title_full | Peroxisome and pexophagy in neurological diseases |
| title_fullStr | Peroxisome and pexophagy in neurological diseases |
| title_full_unstemmed | Peroxisome and pexophagy in neurological diseases |
| title_short | Peroxisome and pexophagy in neurological diseases |
| title_sort | peroxisome and pexophagy in neurological diseases |
| topic | Peroxisome Pexophagy Autophagy Neurological diseases Neuroprotection |
| url | http://www.sciencedirect.com/science/article/pii/S2667325823001425 |
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