Triglyceride-Glucose Index for the Diagnosis of Metabolic Syndrome: A Cross-Sectional Study of 298,652 Individuals Receiving a Health Check-Up in China
Objective. We herein aim to explore the relationship between the triglyceride-glucose (TyG) index and metabolic syndrome (MS). Methods. We enrolled 298,652 individuals with an average age of 47.08 ± 12.94 years and who underwent health check-ups at the First Affiliated Hospital of Wuhu Wannan Medica...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2022/3583603 |
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| author | Mingfei Jiang Xiaoran Li Huan Wu Fan Su Lei Cao Xia Ren Jian Hu Grace Tatenda Mingjia Cheng Yufeng Wen |
| author_facet | Mingfei Jiang Xiaoran Li Huan Wu Fan Su Lei Cao Xia Ren Jian Hu Grace Tatenda Mingjia Cheng Yufeng Wen |
| author_sort | Mingfei Jiang |
| collection | DOAJ |
| description | Objective. We herein aim to explore the relationship between the triglyceride-glucose (TyG) index and metabolic syndrome (MS). Methods. We enrolled 298,652 individuals with an average age of 47.08 ± 12.94 years and who underwent health check-ups at the First Affiliated Hospital of Wuhu Wannan Medical College in this cross-sectional study from 2014 to 2016. We enlisted 125,025 women (41.86%) and 173,627 men (58.14%). The survey information included a questionnaire survey, a physical examination, and a laboratory examination. Results. The prevalence of MS increased gradually in the TyG-index subgroups (Q1, TyG <8.30; Q2, 8.30≤ TyG <8.83; and Q3, TyG ≥8.83). We noted significant differences in hypertension, hyperlipidemia, hyperglycemia, sex, age, body mass index (BMI), smoking and drinking habits, and estimated glomerular filtration rate between the TyG-index subgroups. Multiclass logistic regression analysis showed that the group with TyG <8.30 was the reference group, and the 8.30≤ TyG <8.83 and the TyG ≥8.83 groups exhibited a higher TyG index with MS, and a lower TyG index without MS disease. In the linear curve analysis of the TyG index and MS components, BMI, systolic blood pressure, and diastolic blood pressure showed upward trends, while high-density lipoprotein cholesterol showed no obvious trend in the TyG index at a range of 7.8–11.0. Receiver operating characteristic analysis was used to evaluate the predictive value of the TyG index, triglycerides, and fasting blood glucose for MS, and we found that the area under the TyG index curve was the largest (AUC = 0.89). Conclusion. There were associations between the TyG index and MS and its components, and the TyG index is therefore of great value in the early diagnosis of MS. |
| format | Article |
| id | doaj-art-c957d79a709c427d9c1367e3cd07372c |
| institution | DOAJ |
| issn | 1687-8345 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
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| series | International Journal of Endocrinology |
| spelling | doaj-art-c957d79a709c427d9c1367e3cd07372c2025-08-20T03:23:58ZengWileyInternational Journal of Endocrinology1687-83452022-01-01202210.1155/2022/3583603Triglyceride-Glucose Index for the Diagnosis of Metabolic Syndrome: A Cross-Sectional Study of 298,652 Individuals Receiving a Health Check-Up in ChinaMingfei Jiang0Xiaoran Li1Huan Wu2Fan Su3Lei Cao4Xia Ren5Jian Hu6Grace Tatenda7Mingjia Cheng8Yufeng Wen9Department of DiagnosticsDepartment of RadiologyDepartment of Health and QuarantineDepartment of Prevention MedicalDepartment of Prevention MedicalDepartment of Prevention MedicalDepartment of Prevention MedicalDepartment of Prevention MedicalDepartment of DiagnosticsDepartment of Prevention MedicalObjective. We herein aim to explore the relationship between the triglyceride-glucose (TyG) index and metabolic syndrome (MS). Methods. We enrolled 298,652 individuals with an average age of 47.08 ± 12.94 years and who underwent health check-ups at the First Affiliated Hospital of Wuhu Wannan Medical College in this cross-sectional study from 2014 to 2016. We enlisted 125,025 women (41.86%) and 173,627 men (58.14%). The survey information included a questionnaire survey, a physical examination, and a laboratory examination. Results. The prevalence of MS increased gradually in the TyG-index subgroups (Q1, TyG <8.30; Q2, 8.30≤ TyG <8.83; and Q3, TyG ≥8.83). We noted significant differences in hypertension, hyperlipidemia, hyperglycemia, sex, age, body mass index (BMI), smoking and drinking habits, and estimated glomerular filtration rate between the TyG-index subgroups. Multiclass logistic regression analysis showed that the group with TyG <8.30 was the reference group, and the 8.30≤ TyG <8.83 and the TyG ≥8.83 groups exhibited a higher TyG index with MS, and a lower TyG index without MS disease. In the linear curve analysis of the TyG index and MS components, BMI, systolic blood pressure, and diastolic blood pressure showed upward trends, while high-density lipoprotein cholesterol showed no obvious trend in the TyG index at a range of 7.8–11.0. Receiver operating characteristic analysis was used to evaluate the predictive value of the TyG index, triglycerides, and fasting blood glucose for MS, and we found that the area under the TyG index curve was the largest (AUC = 0.89). Conclusion. There were associations between the TyG index and MS and its components, and the TyG index is therefore of great value in the early diagnosis of MS.http://dx.doi.org/10.1155/2022/3583603 |
| spellingShingle | Mingfei Jiang Xiaoran Li Huan Wu Fan Su Lei Cao Xia Ren Jian Hu Grace Tatenda Mingjia Cheng Yufeng Wen Triglyceride-Glucose Index for the Diagnosis of Metabolic Syndrome: A Cross-Sectional Study of 298,652 Individuals Receiving a Health Check-Up in China International Journal of Endocrinology |
| title | Triglyceride-Glucose Index for the Diagnosis of Metabolic Syndrome: A Cross-Sectional Study of 298,652 Individuals Receiving a Health Check-Up in China |
| title_full | Triglyceride-Glucose Index for the Diagnosis of Metabolic Syndrome: A Cross-Sectional Study of 298,652 Individuals Receiving a Health Check-Up in China |
| title_fullStr | Triglyceride-Glucose Index for the Diagnosis of Metabolic Syndrome: A Cross-Sectional Study of 298,652 Individuals Receiving a Health Check-Up in China |
| title_full_unstemmed | Triglyceride-Glucose Index for the Diagnosis of Metabolic Syndrome: A Cross-Sectional Study of 298,652 Individuals Receiving a Health Check-Up in China |
| title_short | Triglyceride-Glucose Index for the Diagnosis of Metabolic Syndrome: A Cross-Sectional Study of 298,652 Individuals Receiving a Health Check-Up in China |
| title_sort | triglyceride glucose index for the diagnosis of metabolic syndrome a cross sectional study of 298 652 individuals receiving a health check up in china |
| url | http://dx.doi.org/10.1155/2022/3583603 |
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