STAT1 mediates the pro-inflammatory role of GBP5 in colitis

STAT1 mediates the pro-inflammatory role of GBP5 in colitis

Abstract Previous studies establish guanylate binding protein 5 (GBP5) as a driver in the development of inflammatory bowel diseases (IBDs). Here, we aim to elucidate the mechanism underlying the pro-inflammatory role of GBP5. We observe that loss of Gbp5 causes reduced colonic inflammation and decr...

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Main Authors: Yichen Li, Wenxia Wang, Ruixin Zhu, Xinyue Zhu, Mingwei Sun, Yanlan Huang, Wanning Chen, Sheng Gao, Na Jiao, Xutao Lin, Jia Ke, Tao Xu, Linlin Hou, Ping Lan, Lixin Zhu
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-07843-0
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