Association between triglyceride-glucose-body mass index and risk of aortic stenosis progression in patients with non-severe aortic stenosis: a retrospective cohort study
Abstract Background Triglyceride-glucose-BMI (TyG-BMI) index is a surrogate marker of insulin resistance and an important predictor of cardiovascular disease. However, the predictive value of TyG-BMI index in the progression of non-severe aortic stenosis (AS) is still unclear. Methods The present re...
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| Format: | Article |
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BMC
2025-01-01
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| Series: | Cardiovascular Diabetology |
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| Online Access: | https://doi.org/10.1186/s12933-025-02579-x |
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| author | Zhen Guo Zhenyu Xiong Lixiang He Shaozhao Zhang Xinghao Xu Guanzhong Chen Mengjie Xie Wenjing Zhang Ziwen Hui Jiaying Li Xinxue Liao Xiaodong Zhuang |
| author_facet | Zhen Guo Zhenyu Xiong Lixiang He Shaozhao Zhang Xinghao Xu Guanzhong Chen Mengjie Xie Wenjing Zhang Ziwen Hui Jiaying Li Xinxue Liao Xiaodong Zhuang |
| author_sort | Zhen Guo |
| collection | DOAJ |
| description | Abstract Background Triglyceride-glucose-BMI (TyG-BMI) index is a surrogate marker of insulin resistance and an important predictor of cardiovascular disease. However, the predictive value of TyG-BMI index in the progression of non-severe aortic stenosis (AS) is still unclear. Methods The present retrospective observational study was conducted using patient data from Aortic valve diseases RISk facTOr assessmenT andprognosis modeL construction (ARISTOTLE). A total of 190 patients were recruited from one-center. Patients were divided into two groups according to the cut-off value of TyG-BMI index (Ln[triglycerides (mg/dL)* glucose (mg/dL)/2]*BMI). Cox regression and restricted subgroup analysis were used to evaluate the association of TyG-BMI index and progression of non-severe AS. Results A total of 190 patients (mean age 72.52 ± 11.97 years, 51.58% male) were included in the study. During a median follow-up period of 27.48 months, 44 participants experienced disease progression. The cut-off of the TyG-BMI index is 239. After fully adjusting for confounding factors, high TyG-BMI index group was associated with a 2.219-fold higher risk of aortic stenosis progression (HR 2.219, 95%CI 1.086–4.537, p = 0.029). Conclusion TyG-BMI index was significantly associated with a higher risk of progression to non-severe AS. TyG-BMI index, as an effective alternative indicator of IR, can identify people at high risk of AS progression at an early stage of the disease, thereby improving the prognosis and reducing the socio-economic burden. Graphical abstract |
| format | Article |
| id | doaj-art-c9515bdf0d9d4736a2bfb5ccca93f5cc |
| institution | Kabale University |
| issn | 1475-2840 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj-art-c9515bdf0d9d4736a2bfb5ccca93f5cc2025-02-02T12:07:25ZengBMCCardiovascular Diabetology1475-28402025-01-0124111310.1186/s12933-025-02579-xAssociation between triglyceride-glucose-body mass index and risk of aortic stenosis progression in patients with non-severe aortic stenosis: a retrospective cohort studyZhen Guo0Zhenyu Xiong1Lixiang He2Shaozhao Zhang3Xinghao Xu4Guanzhong Chen5Mengjie Xie6Wenjing Zhang7Ziwen Hui8Jiaying Li9Xinxue Liao10Xiaodong Zhuang11Department of Cardiology, the First Affiliated Hospital, Sun Yat-Sen UniversityDepartment of Cardiology, the First Affiliated Hospital, Sun Yat-Sen UniversityDepartment of Cardiology, the First Affiliated Hospital, Sun Yat-Sen UniversityDepartment of Cardiology, the First Affiliated Hospital, Sun Yat-Sen UniversityDepartment of Cardiology, the First Affiliated Hospital, Sun Yat-Sen UniversityDepartment of Cardiology, the First Affiliated Hospital, Sun Yat-Sen UniversityDepartment of Cardiology, the First Affiliated Hospital, Sun Yat-Sen UniversityDepartment of Cardiology, the First Affiliated Hospital, Sun Yat-Sen UniversityDepartment of Cardiology, the First Affiliated Hospital, Sun Yat-Sen UniversityInstitute of Guangdong Provincial Geriatrics, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Southern Medical UniversityDepartment of Cardiology, the First Affiliated Hospital, Sun Yat-Sen UniversityDepartment of Cardiology, the First Affiliated Hospital, Sun Yat-Sen UniversityAbstract Background Triglyceride-glucose-BMI (TyG-BMI) index is a surrogate marker of insulin resistance and an important predictor of cardiovascular disease. However, the predictive value of TyG-BMI index in the progression of non-severe aortic stenosis (AS) is still unclear. Methods The present retrospective observational study was conducted using patient data from Aortic valve diseases RISk facTOr assessmenT andprognosis modeL construction (ARISTOTLE). A total of 190 patients were recruited from one-center. Patients were divided into two groups according to the cut-off value of TyG-BMI index (Ln[triglycerides (mg/dL)* glucose (mg/dL)/2]*BMI). Cox regression and restricted subgroup analysis were used to evaluate the association of TyG-BMI index and progression of non-severe AS. Results A total of 190 patients (mean age 72.52 ± 11.97 years, 51.58% male) were included in the study. During a median follow-up period of 27.48 months, 44 participants experienced disease progression. The cut-off of the TyG-BMI index is 239. After fully adjusting for confounding factors, high TyG-BMI index group was associated with a 2.219-fold higher risk of aortic stenosis progression (HR 2.219, 95%CI 1.086–4.537, p = 0.029). Conclusion TyG-BMI index was significantly associated with a higher risk of progression to non-severe AS. TyG-BMI index, as an effective alternative indicator of IR, can identify people at high risk of AS progression at an early stage of the disease, thereby improving the prognosis and reducing the socio-economic burden. Graphical abstracthttps://doi.org/10.1186/s12933-025-02579-xTriglyceride-glucose-body mass indexAortic stenosisRisk of progression |
| spellingShingle | Zhen Guo Zhenyu Xiong Lixiang He Shaozhao Zhang Xinghao Xu Guanzhong Chen Mengjie Xie Wenjing Zhang Ziwen Hui Jiaying Li Xinxue Liao Xiaodong Zhuang Association between triglyceride-glucose-body mass index and risk of aortic stenosis progression in patients with non-severe aortic stenosis: a retrospective cohort study Cardiovascular Diabetology Triglyceride-glucose-body mass index Aortic stenosis Risk of progression |
| title | Association between triglyceride-glucose-body mass index and risk of aortic stenosis progression in patients with non-severe aortic stenosis: a retrospective cohort study |
| title_full | Association between triglyceride-glucose-body mass index and risk of aortic stenosis progression in patients with non-severe aortic stenosis: a retrospective cohort study |
| title_fullStr | Association between triglyceride-glucose-body mass index and risk of aortic stenosis progression in patients with non-severe aortic stenosis: a retrospective cohort study |
| title_full_unstemmed | Association between triglyceride-glucose-body mass index and risk of aortic stenosis progression in patients with non-severe aortic stenosis: a retrospective cohort study |
| title_short | Association between triglyceride-glucose-body mass index and risk of aortic stenosis progression in patients with non-severe aortic stenosis: a retrospective cohort study |
| title_sort | association between triglyceride glucose body mass index and risk of aortic stenosis progression in patients with non severe aortic stenosis a retrospective cohort study |
| topic | Triglyceride-glucose-body mass index Aortic stenosis Risk of progression |
| url | https://doi.org/10.1186/s12933-025-02579-x |
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