Prevalence of drug resistance in clinical isolates of tuberculosis from GCC: a literature review from January 2002 to March 2013
Introduction: The prevalence of drug resistance in clinical isolates of Mycobacterium tuberculosis from the Gulf Cooperation Council (GCC; Saudi Arabia, Qatar, Bahrain, Kuwait, Oman, United Arab Emirates [UAE]) countries was appraised using reports published between January 2002 and March 2013. Met...
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The Journal of Infection in Developing Countries
2014-09-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/4053 |
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| author | Mohammed Yahya Areeshi Shekhar Chandra Bisht Raju Kumar Mandal Shafiul Haque |
| author_facet | Mohammed Yahya Areeshi Shekhar Chandra Bisht Raju Kumar Mandal Shafiul Haque |
| author_sort | Mohammed Yahya Areeshi |
| collection | DOAJ |
| description | Introduction: The prevalence of drug resistance in clinical isolates of Mycobacterium tuberculosis from the Gulf Cooperation Council (GCC; Saudi Arabia, Qatar, Bahrain, Kuwait, Oman, United Arab Emirates [UAE]) countries was appraised using reports published between January 2002 and March 2013.
Methodology: A total of 11,393 tuberculosis (TB) isolates from the GCC were studied through published literature and were analyzed statistically.
Results: Most of the isolates were resistant to isoniazid, followed by streptomycin, rifampin, ethambutol, and pyrazinamide. The highest prevalence rate of multidrug-resistant-TB (MDR-TB) was found in UAE (9.2%), followed by Kuwait (5.9%) and Saudi Arabia (4.3%). The overall MDR-TB prevalence rate was recorded as 4.0% in the entire GCC region. Automated linear modeling revealed that isoniazid resistance had a strong relationship with the prevalence of MDR-TB in all the GCC countries and was found to be the strongest predictor for MDR-TB. Interestingly, rifampicin resistance was significantly associated with the prevalence of MDR-TB in Oman, Kuwait, and Saudi Arabia, while isoniazid was identified for UAE. On the basis of a number of reports and isolates, the principal component analysis showed that, among all GCC member countries, the highest burden of TB was in Saudi Arabia and Kuwait, and maximum drug resistance was present in UAE.
Conclusion: The study demonstrates that the prevalence of MDR-TB in GCC countries is almost equal to other developing and developed countries, and requires immediate attention for surveillance and control.
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| format | Article |
| id | doaj-art-c94f477ee7264c3fa508c8e6d003ebf0 |
| institution | DOAJ |
| issn | 1972-2680 |
| language | English |
| publishDate | 2014-09-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-c94f477ee7264c3fa508c8e6d003ebf02025-08-20T02:57:14ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802014-09-0180910.3855/jidc.4053Prevalence of drug resistance in clinical isolates of tuberculosis from GCC: a literature review from January 2002 to March 2013Mohammed Yahya Areeshi0Shekhar Chandra Bisht1Raju Kumar Mandal2Shafiul Haque3College of Nursing and Allied Health Sciences, Jazan University, Jazan, Saudi ArabiaHemwati Nandan Bahuguna Garhwal University, Srinagar (Garhwal), Uttarakhand, IndiaCollege of Nursing and Allied Health Sciences, Jazan University, Jazan, Saudi ArabiaCollege of Nursing and Allied Health Sciences, Jazan University, Jazan, Saudi ArabiaIntroduction: The prevalence of drug resistance in clinical isolates of Mycobacterium tuberculosis from the Gulf Cooperation Council (GCC; Saudi Arabia, Qatar, Bahrain, Kuwait, Oman, United Arab Emirates [UAE]) countries was appraised using reports published between January 2002 and March 2013. Methodology: A total of 11,393 tuberculosis (TB) isolates from the GCC were studied through published literature and were analyzed statistically. Results: Most of the isolates were resistant to isoniazid, followed by streptomycin, rifampin, ethambutol, and pyrazinamide. The highest prevalence rate of multidrug-resistant-TB (MDR-TB) was found in UAE (9.2%), followed by Kuwait (5.9%) and Saudi Arabia (4.3%). The overall MDR-TB prevalence rate was recorded as 4.0% in the entire GCC region. Automated linear modeling revealed that isoniazid resistance had a strong relationship with the prevalence of MDR-TB in all the GCC countries and was found to be the strongest predictor for MDR-TB. Interestingly, rifampicin resistance was significantly associated with the prevalence of MDR-TB in Oman, Kuwait, and Saudi Arabia, while isoniazid was identified for UAE. On the basis of a number of reports and isolates, the principal component analysis showed that, among all GCC member countries, the highest burden of TB was in Saudi Arabia and Kuwait, and maximum drug resistance was present in UAE. Conclusion: The study demonstrates that the prevalence of MDR-TB in GCC countries is almost equal to other developing and developed countries, and requires immediate attention for surveillance and control. https://jidc.org/index.php/journal/article/view/4053Mycobacterium tuberculosisTBdrug-resistanceGCCGulf countriesMDR-TB |
| spellingShingle | Mohammed Yahya Areeshi Shekhar Chandra Bisht Raju Kumar Mandal Shafiul Haque Prevalence of drug resistance in clinical isolates of tuberculosis from GCC: a literature review from January 2002 to March 2013 Journal of Infection in Developing Countries Mycobacterium tuberculosis TB drug-resistance GCC Gulf countries MDR-TB |
| title | Prevalence of drug resistance in clinical isolates of tuberculosis from GCC: a literature review from January 2002 to March 2013 |
| title_full | Prevalence of drug resistance in clinical isolates of tuberculosis from GCC: a literature review from January 2002 to March 2013 |
| title_fullStr | Prevalence of drug resistance in clinical isolates of tuberculosis from GCC: a literature review from January 2002 to March 2013 |
| title_full_unstemmed | Prevalence of drug resistance in clinical isolates of tuberculosis from GCC: a literature review from January 2002 to March 2013 |
| title_short | Prevalence of drug resistance in clinical isolates of tuberculosis from GCC: a literature review from January 2002 to March 2013 |
| title_sort | prevalence of drug resistance in clinical isolates of tuberculosis from gcc a literature review from january 2002 to march 2013 |
| topic | Mycobacterium tuberculosis TB drug-resistance GCC Gulf countries MDR-TB |
| url | https://jidc.org/index.php/journal/article/view/4053 |
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