Distinctive Structural and Effective Connectivity Changes of Semantic Cognition Network across Left and Right Mesial Temporal Lobe Epilepsy Patients
Occurrence of language impairment in mesial temporal lobe epilepsy (mTLE) patients is common and left mTLE patients always exhibit a primary problem with access to names. To explore different neuropsychological profiles between left and right mTLE patients, the study investigated both structural and...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2016/8583420 |
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| author | Xiaotong Fan Hao Yan Yi Shan Kun Shang Xiaocui Wang Peipei Wang Yongzhi Shan Jie Lu Guoguang Zhao |
| author_facet | Xiaotong Fan Hao Yan Yi Shan Kun Shang Xiaocui Wang Peipei Wang Yongzhi Shan Jie Lu Guoguang Zhao |
| author_sort | Xiaotong Fan |
| collection | DOAJ |
| description | Occurrence of language impairment in mesial temporal lobe epilepsy (mTLE) patients is common and left mTLE patients always exhibit a primary problem with access to names. To explore different neuropsychological profiles between left and right mTLE patients, the study investigated both structural and effective functional connectivity changes within the semantic cognition network between these two groups and those from normal controls. We found that gray matter atrophy of left mTLE patients was more severe than that of right mTLE patients in the whole brain and especially within the semantic cognition network in their contralateral hemisphere. It suggested that seizure attacks were rather targeted than random for patients with hippocampal sclerosis (HS) in the dominant hemisphere. Functional connectivity analysis during resting state fMRI revealed that subregions of the anterior temporal lobe (ATL) in the left HS patients were no longer effectively connected. Further, we found that, unlike in right HS patients, increased causal linking between ipsilateral regions in the left HS epilepsy patients cannot make up for their decreased contralateral interaction. It suggested that weakened contralateral connection and disrupted effective interaction between subregions of the unitary, transmodal hub of the ATL may be the primary cause of anomia in the left HS patients. |
| format | Article |
| id | doaj-art-c9492ef60f354564b08f8871bf123941 |
| institution | OA Journals |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-c9492ef60f354564b08f8871bf1239412025-08-20T02:19:41ZengWileyNeural Plasticity2090-59041687-54432016-01-01201610.1155/2016/85834208583420Distinctive Structural and Effective Connectivity Changes of Semantic Cognition Network across Left and Right Mesial Temporal Lobe Epilepsy PatientsXiaotong Fan0Hao Yan1Yi Shan2Kun Shang3Xiaocui Wang4Peipei Wang5Yongzhi Shan6Jie Lu7Guoguang Zhao8Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, ChinaDepartments of Psychology and Linguistics, Xidian University, Xi’an 710126, ChinaDepartment of Radiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, ChinaDepartment of Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing 100053, ChinaDepartment of Biomedical Engineering, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, ChinaDepartment of Radiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, ChinaDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, ChinaDepartment of Radiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, ChinaDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, ChinaOccurrence of language impairment in mesial temporal lobe epilepsy (mTLE) patients is common and left mTLE patients always exhibit a primary problem with access to names. To explore different neuropsychological profiles between left and right mTLE patients, the study investigated both structural and effective functional connectivity changes within the semantic cognition network between these two groups and those from normal controls. We found that gray matter atrophy of left mTLE patients was more severe than that of right mTLE patients in the whole brain and especially within the semantic cognition network in their contralateral hemisphere. It suggested that seizure attacks were rather targeted than random for patients with hippocampal sclerosis (HS) in the dominant hemisphere. Functional connectivity analysis during resting state fMRI revealed that subregions of the anterior temporal lobe (ATL) in the left HS patients were no longer effectively connected. Further, we found that, unlike in right HS patients, increased causal linking between ipsilateral regions in the left HS epilepsy patients cannot make up for their decreased contralateral interaction. It suggested that weakened contralateral connection and disrupted effective interaction between subregions of the unitary, transmodal hub of the ATL may be the primary cause of anomia in the left HS patients.http://dx.doi.org/10.1155/2016/8583420 |
| spellingShingle | Xiaotong Fan Hao Yan Yi Shan Kun Shang Xiaocui Wang Peipei Wang Yongzhi Shan Jie Lu Guoguang Zhao Distinctive Structural and Effective Connectivity Changes of Semantic Cognition Network across Left and Right Mesial Temporal Lobe Epilepsy Patients Neural Plasticity |
| title | Distinctive Structural and Effective Connectivity Changes of Semantic Cognition Network across Left and Right Mesial Temporal Lobe Epilepsy Patients |
| title_full | Distinctive Structural and Effective Connectivity Changes of Semantic Cognition Network across Left and Right Mesial Temporal Lobe Epilepsy Patients |
| title_fullStr | Distinctive Structural and Effective Connectivity Changes of Semantic Cognition Network across Left and Right Mesial Temporal Lobe Epilepsy Patients |
| title_full_unstemmed | Distinctive Structural and Effective Connectivity Changes of Semantic Cognition Network across Left and Right Mesial Temporal Lobe Epilepsy Patients |
| title_short | Distinctive Structural and Effective Connectivity Changes of Semantic Cognition Network across Left and Right Mesial Temporal Lobe Epilepsy Patients |
| title_sort | distinctive structural and effective connectivity changes of semantic cognition network across left and right mesial temporal lobe epilepsy patients |
| url | http://dx.doi.org/10.1155/2016/8583420 |
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