Corticomuscular Coupling Alterations During Elbow Isometric Contraction Correlated With Clinical Scores: An fNIRS-sEMG Study in Stroke Survivors
The study aimed to investigate changes in corticomuscular coupling during elbow flexion and extension in stroke survivors using functional near-infrared spectroscopy (fNIRS) and surface electromyography (sEMG), and to evaluate the relationship between coupling characteristics and clinical assessment...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
IEEE
2025-01-01
|
| Series: | IEEE Transactions on Neural Systems and Rehabilitation Engineering |
| Subjects: | |
| Online Access: | https://ieeexplore.ieee.org/document/10857365/ |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823859642419118080 |
|---|---|
| author | Xiaohan Wang Weidong Li Rong Song Di Ao Huijing Hu Le Li |
| author_facet | Xiaohan Wang Weidong Li Rong Song Di Ao Huijing Hu Le Li |
| author_sort | Xiaohan Wang |
| collection | DOAJ |
| description | The study aimed to investigate changes in corticomuscular coupling during elbow flexion and extension in stroke survivors using functional near-infrared spectroscopy (fNIRS) and surface electromyography (sEMG), and to evaluate the relationship between coupling characteristics and clinical assessment scales. This study recruited 12 stroke survivors and 12 age-matched healthy subjects, and further divided the subjects into the affected side group, healthy-side group and age-matched healthy group. They performed elbow flexion and extension tasks at 30% and 70% of the maximum voluntary contraction (MVC). The cerebral blood flow dynamics of the bilateral prefrontal cortex, motor cortex, and occipital lobe, along with sEMG signals from the biceps brachii and triceps brachii, were simultaneously recorded. At matched force levels, the fuzzy approximate entropy values of both agonist and antagonistic muscles were notably lower in the affected group compared to the healthy group (P < 0.05). The effective connectivity from the ipsilateral motor cortex to the contralateral motor cortex during elbow movements in the affected group showed a meaningful positive association with the Fugl-Meyer Assessment (FMA) scale. Additionally, the transfer entropy from the contralateral motor cortex to the agonist muscle in the affected group demonstrated a significant positive correlation with the FMA scale at 70% MVC during elbow flexion. This research identified differences in intermuscular coordination, brain network connectivity, and corticomuscular coupling between stroke survivors and healthy individuals during motor tasks and our findings suggest that it can serve as a potential quantitative marker for assessing upper limb motor function post-stroke. The relationship between these characteristics and clinical scales signifies potential quantitative assessment parameters for stroke rehabilitation, underscoring the importance of exploring corticomuscular coupling in the recovery of upper limb motor function post-stroke. |
| format | Article |
| id | doaj-art-c948a27fda6548dbbb17b0c3ff3e7da1 |
| institution | Kabale University |
| issn | 1534-4320 1558-0210 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | IEEE |
| record_format | Article |
| series | IEEE Transactions on Neural Systems and Rehabilitation Engineering |
| spelling | doaj-art-c948a27fda6548dbbb17b0c3ff3e7da12025-02-11T00:00:08ZengIEEEIEEE Transactions on Neural Systems and Rehabilitation Engineering1534-43201558-02102025-01-013369670410.1109/TNSRE.2025.353592810857365Corticomuscular Coupling Alterations During Elbow Isometric Contraction Correlated With Clinical Scores: An fNIRS-sEMG Study in Stroke SurvivorsXiaohan Wang0https://orcid.org/0000-0001-7608-2071Weidong Li1Rong Song2https://orcid.org/0000-0003-3662-116XDi Ao3https://orcid.org/0000-0002-0247-3114Huijing Hu4Le Li5https://orcid.org/0000-0002-9340-9061Institute of Medical Research, Northwestern Polytechnical University, Xi’an, Shaanxi, ChinaRehabilitation Therapy Department I, Rehabilitation Hospital, North Branch, Xi’an International Medical Center Hospital, Xi’an, Shaanxi, ChinaKey Laboratory of Sensing Technology and Biomedical Instrument of Guangdong Province, School of Biomedical Engineering, Sun Yat-sen University, Shenzhen, ChinaRehabilitation Therapy Department I, Rehabilitation Hospital, North Branch, Xi’an International Medical Center Hospital, Xi’an, Shaanxi, ChinaRehabilitation Therapy Department I, Rehabilitation Hospital, North Branch, Xi’an International Medical Center Hospital, Xi’an, Shaanxi, ChinaRehabilitation Therapy Department I, Rehabilitation Hospital, North Branch, Xi’an International Medical Center Hospital, Xi’an, Shaanxi, ChinaThe study aimed to investigate changes in corticomuscular coupling during elbow flexion and extension in stroke survivors using functional near-infrared spectroscopy (fNIRS) and surface electromyography (sEMG), and to evaluate the relationship between coupling characteristics and clinical assessment scales. This study recruited 12 stroke survivors and 12 age-matched healthy subjects, and further divided the subjects into the affected side group, healthy-side group and age-matched healthy group. They performed elbow flexion and extension tasks at 30% and 70% of the maximum voluntary contraction (MVC). The cerebral blood flow dynamics of the bilateral prefrontal cortex, motor cortex, and occipital lobe, along with sEMG signals from the biceps brachii and triceps brachii, were simultaneously recorded. At matched force levels, the fuzzy approximate entropy values of both agonist and antagonistic muscles were notably lower in the affected group compared to the healthy group (P < 0.05). The effective connectivity from the ipsilateral motor cortex to the contralateral motor cortex during elbow movements in the affected group showed a meaningful positive association with the Fugl-Meyer Assessment (FMA) scale. Additionally, the transfer entropy from the contralateral motor cortex to the agonist muscle in the affected group demonstrated a significant positive correlation with the FMA scale at 70% MVC during elbow flexion. This research identified differences in intermuscular coordination, brain network connectivity, and corticomuscular coupling between stroke survivors and healthy individuals during motor tasks and our findings suggest that it can serve as a potential quantitative marker for assessing upper limb motor function post-stroke. The relationship between these characteristics and clinical scales signifies potential quantitative assessment parameters for stroke rehabilitation, underscoring the importance of exploring corticomuscular coupling in the recovery of upper limb motor function post-stroke.https://ieeexplore.ieee.org/document/10857365/Corticomuscular couplingmotor functionfunctional near-infrared spectroscopy (fNIRS)surface electromyography (sEMG)stroke |
| spellingShingle | Xiaohan Wang Weidong Li Rong Song Di Ao Huijing Hu Le Li Corticomuscular Coupling Alterations During Elbow Isometric Contraction Correlated With Clinical Scores: An fNIRS-sEMG Study in Stroke Survivors IEEE Transactions on Neural Systems and Rehabilitation Engineering Corticomuscular coupling motor function functional near-infrared spectroscopy (fNIRS) surface electromyography (sEMG) stroke |
| title | Corticomuscular Coupling Alterations During Elbow Isometric Contraction Correlated With Clinical Scores: An fNIRS-sEMG Study in Stroke Survivors |
| title_full | Corticomuscular Coupling Alterations During Elbow Isometric Contraction Correlated With Clinical Scores: An fNIRS-sEMG Study in Stroke Survivors |
| title_fullStr | Corticomuscular Coupling Alterations During Elbow Isometric Contraction Correlated With Clinical Scores: An fNIRS-sEMG Study in Stroke Survivors |
| title_full_unstemmed | Corticomuscular Coupling Alterations During Elbow Isometric Contraction Correlated With Clinical Scores: An fNIRS-sEMG Study in Stroke Survivors |
| title_short | Corticomuscular Coupling Alterations During Elbow Isometric Contraction Correlated With Clinical Scores: An fNIRS-sEMG Study in Stroke Survivors |
| title_sort | corticomuscular coupling alterations during elbow isometric contraction correlated with clinical scores an fnirs semg study in stroke survivors |
| topic | Corticomuscular coupling motor function functional near-infrared spectroscopy (fNIRS) surface electromyography (sEMG) stroke |
| url | https://ieeexplore.ieee.org/document/10857365/ |
| work_keys_str_mv | AT xiaohanwang corticomuscularcouplingalterationsduringelbowisometriccontractioncorrelatedwithclinicalscoresanfnirssemgstudyinstrokesurvivors AT weidongli corticomuscularcouplingalterationsduringelbowisometriccontractioncorrelatedwithclinicalscoresanfnirssemgstudyinstrokesurvivors AT rongsong corticomuscularcouplingalterationsduringelbowisometriccontractioncorrelatedwithclinicalscoresanfnirssemgstudyinstrokesurvivors AT diao corticomuscularcouplingalterationsduringelbowisometriccontractioncorrelatedwithclinicalscoresanfnirssemgstudyinstrokesurvivors AT huijinghu corticomuscularcouplingalterationsduringelbowisometriccontractioncorrelatedwithclinicalscoresanfnirssemgstudyinstrokesurvivors AT leli corticomuscularcouplingalterationsduringelbowisometriccontractioncorrelatedwithclinicalscoresanfnirssemgstudyinstrokesurvivors |