The unique structure of the apicoplast genome of the rodent malaria parasite Plasmodium chabaudi chabaudi.
The apicoplast, a non-photosynthetic plastid of apicomplexan species, has an extremely reduced but highly conserved genome. Here, the apicoplast genome of the rodent malaria parasite Plasmodium chabaudi chabaudi (Pcc) isolate CB was characterized. Although the set of genes in the genome is identical...
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0061778&type=printable |
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| author | Shigeharu Sato Shigeharu Sato Abdul K Sesay Anthony A Holder |
| author_facet | Shigeharu Sato Shigeharu Sato Abdul K Sesay Anthony A Holder |
| author_sort | Shigeharu Sato |
| collection | DOAJ |
| description | The apicoplast, a non-photosynthetic plastid of apicomplexan species, has an extremely reduced but highly conserved genome. Here, the apicoplast genome of the rodent malaria parasite Plasmodium chabaudi chabaudi (Pcc) isolate CB was characterized. Although the set of genes in the genome is identical, the copy number of some tRNA genes differs between Pcc and other Plasmodium species because the Pcc DNA has only one rRNA/tRNA gene cluster, which is normally duplicated in other species. The location of the duplicated trnR(ACG) and trnM implies that one of the duplicated clusters in the ancestral molecule has been lost due to an intramolecular recombination event. The Pcc DNA occurs in two isoforms with an internal inversion between them. The presence of a unique variant in the duplicated trnT gene suggests that the two isoforms are interconvertible. This is the first report of the complete nucleotide sequence of a Plasmodium apicoplast DNA. |
| format | Article |
| id | doaj-art-c947b052f83448c7b53ea713ef21b77a |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-c947b052f83448c7b53ea713ef21b77a2025-08-20T02:30:37ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0184e6177810.1371/journal.pone.0061778The unique structure of the apicoplast genome of the rodent malaria parasite Plasmodium chabaudi chabaudi.Shigeharu SatoShigeharu SatoAbdul K SesayAnthony A HolderThe apicoplast, a non-photosynthetic plastid of apicomplexan species, has an extremely reduced but highly conserved genome. Here, the apicoplast genome of the rodent malaria parasite Plasmodium chabaudi chabaudi (Pcc) isolate CB was characterized. Although the set of genes in the genome is identical, the copy number of some tRNA genes differs between Pcc and other Plasmodium species because the Pcc DNA has only one rRNA/tRNA gene cluster, which is normally duplicated in other species. The location of the duplicated trnR(ACG) and trnM implies that one of the duplicated clusters in the ancestral molecule has been lost due to an intramolecular recombination event. The Pcc DNA occurs in two isoforms with an internal inversion between them. The presence of a unique variant in the duplicated trnT gene suggests that the two isoforms are interconvertible. This is the first report of the complete nucleotide sequence of a Plasmodium apicoplast DNA.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0061778&type=printable |
| spellingShingle | Shigeharu Sato Shigeharu Sato Abdul K Sesay Anthony A Holder The unique structure of the apicoplast genome of the rodent malaria parasite Plasmodium chabaudi chabaudi. PLoS ONE |
| title | The unique structure of the apicoplast genome of the rodent malaria parasite Plasmodium chabaudi chabaudi. |
| title_full | The unique structure of the apicoplast genome of the rodent malaria parasite Plasmodium chabaudi chabaudi. |
| title_fullStr | The unique structure of the apicoplast genome of the rodent malaria parasite Plasmodium chabaudi chabaudi. |
| title_full_unstemmed | The unique structure of the apicoplast genome of the rodent malaria parasite Plasmodium chabaudi chabaudi. |
| title_short | The unique structure of the apicoplast genome of the rodent malaria parasite Plasmodium chabaudi chabaudi. |
| title_sort | unique structure of the apicoplast genome of the rodent malaria parasite plasmodium chabaudi chabaudi |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0061778&type=printable |
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